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Frontiers in Neuroscience, volume 17

Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis

Amelchenko Evgeny M. ^{1, 2}

Bezriadnov Dmitri V ³

Chekhov Olga A. ^{1, 2}

Anokhin Konstantin V ^{3, 4}

Lazutkin Alexander A ^{1, 2, 5}

Enikolopov Grigori ^{1, 2}

Hide authors affiliations Show authors affiliations: 5 affiliations

Center for Developmental Genetics, United States |

Department of Anesthesiology, Stony Brook University, United States |

P.K. Anokhin Research Institute of Normal Physiology RAS, Russia |

⁴

Institute for Advanced Brain Studies, Lomonosov Moscow State University, Russia |

⁵

Institute of Higher Nervous Activity and Neurophysiology RAS, Russia |

Publication type: Journal Article

Publication date: 2023-08-14

Frontiers Media S.A.

Journal: Frontiers in Neuroscience

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Impact factor: 4.3

ISSN: 16624548, 1662453X

DOI: 10.3389/fnins.2023.1232670

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PubMed ID: 37645372

General Neuroscience

Abstract

Aging is associated with impairments in learning, memory, and cognitive flexibility, as well as a gradual decline in hippocampal neurogenesis. We investigated the performance of 6-and 14-month-old mice (considered mature adult and late middle age, respectively) in learning and memory tasks based on the Morris water maze (MWM) and determined their levels of preceding and current neurogenesis. While both age groups successfully performed in the spatial version of MWM (sMWM), the older mice were less efficient compared to the younger mice when presented with modified versions of the MWM that required a reassessment of the previously acquired experience. This was detected in the reversal version of MWM (rMWM) and was particularly evident in the context discrimination MWM (cdMWM), a novel task that required integrating various distal cues, local cues, and altered contexts and adjusting previously used search strategies. Older mice were impaired in several metrics that characterize rMWM and cdMWM, however, they showed improvement and narrowed the performance gap with the younger mice after additional training. Furthermore, we analyzed the adult-born mature and immature neurons in the hippocampal dentate gyrus and found a significant correlation between neurogenesis levels in individual mice and their performance in the tasks demanding cognitive flexibility. These results provide a detailed description of the age-related changes in learning and memory and underscore the importance of hippocampal neurogenesis in supporting cognitive flexibility.

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Neuroscience Letters	Neuroscience Letters, 1, 50% Neuroscience Letters 1 publication, 50%
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Elsevier	Elsevier, 1, 50% Elsevier 1 publication, 50%
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Amelchenko E. M. et al. Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis // Frontiers in Neuroscience. 2023. Vol. 17.

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Amelchenko E. M., Bezriadnov D. V., Chekhov O. A., Anokhin K. V., Lazutkin A. A., Enikolopov G. Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis // Frontiers in Neuroscience. 2023. Vol. 17.

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TY - JOUR

DO - 10.3389/fnins.2023.1232670

UR - https://doi.org/10.3389%2Ffnins.2023.1232670

TI - Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis

T2 - Frontiers in Neuroscience

AU - Amelchenko, Evgeny M.

AU - Bezriadnov, Dmitri V

AU - Chekhov, Olga A.

AU - Anokhin, Konstantin V

AU - Lazutkin, Alexander A

AU - Enikolopov, Grigori

PY - 2023

DA - 2023/08/14 00:00:00

PB - Frontiers Media S.A.

VL - 17

PMID - 37645372

SN - 1662-4548

SN - 1662-453X

ER -

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@article{2023_Amelchenko,

author = {Evgeny M. Amelchenko and Dmitri V Bezriadnov and Olga A. Chekhov and Konstantin V Anokhin and Alexander A Lazutkin and Grigori Enikolopov},

title = {Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis},

journal = {Frontiers in Neuroscience},

year = {2023},

volume = {17},

publisher = {Frontiers Media S.A.},

month = {aug},

url = {https://doi.org/10.3389%2Ffnins.2023.1232670},

doi = {10.3389/fnins.2023.1232670}

}

Found error?

Publisher

Frontiers Media S.A.

Journal

Frontiers in Neuroscience

Quartile SCImago

Quartile WOS

Impact factor

4.3

ISSN

16624548 (Print)
1662453X (Electronic)

Labs

A group of brain stem cells

Profiles

Lazutkin, Alexander A