Open Access
Frontiers in Cell and Developmental Biology, volume 9
PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins
2
Publication type: Journal Article
Publication date: 2021-05-19
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.5
ISSN: 2296634X
PubMed ID:
34095104
Cell Biology
Developmental Biology
Abstract
Poly(ADP-ribose) polymerase 1 (PARP1) is established as a key regulator of the cellular DNA damage response and apoptosis. In addition, PARP1 participates in the global regulation of DNA repair, transcription, telomere maintenance, and inflammation response by modulating various DNA-protein and protein-protein interactions. Recently, it was reported that PARP1 also influences splicing and ribosomal RNA biogenesis. The H/ACA ribonucleoprotein complex is involved in a variety of cellular processes such as RNA maturation. It contains non-coding RNAs with specific H/ACA domains and four proteins: dyskerin (DKC1), GAR1, NHP2, and NOP10. Two of these proteins, DKC1 and GAR1, are targets of poly(ADP-ribosyl)ation catalyzed by PARP1. The H/ACA RNA-binding proteins are involved in the regulation of maturation and activity of the telomerase complex, which maintains telomere length. In this study, we demonstrated that of poly(ADP-ribosyl)ation influences on RNA-binding properties of DKC1 and GAR1 and telomerase assembly and activity. Our data provide the evidence that poly(ADP-ribosyl)ation regulates telomerase complex assembly and activity, in turn regulating telomere length that may be useful for design and development of anticancer therapeutic approaches that are based on the inhibition of PARP1 and telomerase activities.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Savelyev N. V. et al. PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins // Frontiers in Cell and Developmental Biology. 2021. Vol. 9.
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Savelyev N. V., Shepelev N. M., Lavrik O., Rubtsova M. P., Dontsova O. A. PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins // Frontiers in Cell and Developmental Biology. 2021. Vol. 9.
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TY - JOUR
DO - 10.3389/fcell.2021.621134
UR - https://doi.org/10.3389%2Ffcell.2021.621134
TI - PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins
T2 - Frontiers in Cell and Developmental Biology
AU - Savelyev, Nikita V
AU - Shepelev, Nikita M
AU - Lavrik, Olga I.
AU - Rubtsova, Maria P
AU - Dontsova, Olga A.
PY - 2021
DA - 2021/05/19 00:00:00
PB - Frontiers Media S.A.
VL - 9
PMID - 34095104
SN - 2296-634X
ER -
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@article{2021_Savelyev,
author = {Nikita V Savelyev and Nikita M Shepelev and Olga I. Lavrik and Maria P Rubtsova and Olga A. Dontsova},
title = {PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins},
journal = {Frontiers in Cell and Developmental Biology},
year = {2021},
volume = {9},
publisher = {Frontiers Media S.A.},
month = {may},
url = {https://doi.org/10.3389%2Ffcell.2021.621134},
doi = {10.3389/fcell.2021.621134}
}