Open Access
Open access
Frontiers in Cell and Developmental Biology, том 9

Human Telomerase RNA Protein Encoded by Telomerase RNA is Involved in Metabolic Responses

Тип документаJournal Article
Дата публикации2021-12-07
ИздательFrontiers Media S.A.
Название журналаFrontiers in Cell and Developmental Biology
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 20216.08
Cell Biology
Developmental Biology
Краткое описание
Cell proliferation is associated with increased energy and nutrients consumption. Metabolism switch from oxidative phosphorylation to glycolysis and telomerase activity are induced during stimulation of proliferation, such as tumorigenesis, immune cell activation, and stem cell differentiation, among others. Telomerase RNA is one of the core components of the telomerase complex and participates in survival mechanisms that are activated under stress conditions. Human telomerase RNA protein (hTERP) is encoded by telomerase RNA and has been recently shown to be involved in autophagy regulation. In this study, we demonstrated the role of hTERP in the modulation of signaling pathways regulating autophagy, protein biosynthesis, and cell proliferation. The AMPK signaling pathway was affected in cells deficient of hTERP and when hTERP was overexpressed. The appearance of hTERP is important for metabolism switching associated with the accelerated proliferation of cells in healthy and pathological processes. These findings demonstrate the connection between telomerase RNA biogenesis and function and signaling pathways.
Пристатейные ссылки: 52
Human telomerase RNA: Telomerase component or more?
Rubtsova M., Dontsova O.
Q2 Biomolecules 2020 цитирований: 11
Open Access
Open access
Regulation of human telomerase in homeostasis and disease
Roake C.M., Artandi S.E.
Q1 Nature Reviews Molecular Cell Biology 2020 цитирований: 107
AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control.
González A., Hall M.N., Lin S., Hardie D.G.
Q1 Cell Metabolism 2020 цитирований: 131
The mTOR pathway is necessary for survival of mice with short telomeres
Ferrara-Romeo I., Martinez P., Saraswati S., Whittemore K., Graña-Castro O., Thelma Poluha L., Serrano R., Hernandez-Encinas E., Blanco-Aparicio C., Maria Flores J., Blasco M.A.
Q1 Nature Communications 2020 цитирований: 28
Open Access
Open access
Non-canonical Roles of Telomerase: Unraveling the Imbroglio
Ségal-Bendirdjian E., Geli V.
Q1 Frontiers in Cell and Developmental Biology 2019 цитирований: 38
Open Access
Open access
Integrator is a key component of human telomerase RNA biogenesis
Rubtsova M.P., Vasilkova D.P., Moshareva M.A., Malyavko A.N., Meerson M.B., Zatsepin T.S., Naraykina Y.V., Beletsky A.V., Ravin N.V., Dontsova O.A.
Q1 Scientific Reports 2019 цитирований: 28
Open Access
Open access
A Double Negative Feedback Loop between mTORC1 and AMPK Kinases Guarantees Precise Autophagy Induction upon Cellular Stress
Holczer M., Hajdú B., Lőrincz T., Szarka A., Bánhegyi G., Kapuy O.
Q1 International Journal of Molecular Sciences 2019 цитирований: 34
Open Access
Open access
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
Hoxhaj G., Manning B.D.
Q1 Nature Reviews Cancer 2019 цитирований: 602
Nutrient regulation of mTORC1 at a glance
Condon K.J., Sabatini D.M.
Q1 Journal of Cell Science 2019 цитирований: 92
Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease.
Roake C.M., Chen L., Chakravarthy A.L., Ferrell J.E., Raffa G.D., Artandi S.E.
Q1 Molecular Cell 2019 цитирований: 25
Protein encoded in human telomerase RNA is involved in cell protective pathways
Rubtsova M., Naraykina Y., Vasilkova D., Meerson M., Zvereva M., Prassolov V., Lazarev V., Manuvera V., Kovalchuk S., Anikanov N., Butenko I., Pobeguts O., Govorun V., Dontsova O.
Q1 Nucleic Acids Research 2018 цитирований: 28
Open Access
Open access
Mitochondrial Trafficking and Processing of Telomerase RNA TERC
Cheng Y., Liu P., Zheng Q., Gao G., Yuan J., Wang P., Huang J., Xie L., Lu X., Tong T., Chen J., Lu Z., Guan J., Wang G.
Q1 Cell Reports 2018 цитирований: 27
Open Access
Open access
Hexokinase 2 is a molecular bridge linking telomerase and autophagy
Roh J., Kim Y., Oh J., Kim Y., Lee J., Lee J., Chun K., Lee H.
Q1 PLoS ONE 2018 цитирований: 21
Open Access
Open access
Somatic growth and telomere dynamics in vertebrates: relationships, mechanisms and consequences
Monaghan P., Ozanne S.E.
Q1 Philosophical Transactions of the Royal Society B: Biological Sciences 2018 цитирований: 98
ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
Zhao Y., Hu X., Liu Y., Dong S., Wen Z., He W., Zhang S., Huang Q., Shi M.
Q1 Molecular Cancer 2017 цитирований: 314
Open Access
Open access


1. Shliapina V. и др. Human Telomerase RNA Protein Encoded by Telomerase RNA is Involved in Metabolic Responses // Frontiers in Cell and Developmental Biology. 2021. Т. 9.


DO - 10.3389/fcell.2021.754611

UR -

TI - Human Telomerase RNA Protein Encoded by Telomerase RNA is Involved in Metabolic Responses

T2 - Frontiers in Cell and Developmental Biology

AU - Shliapina, Viktoriia

AU - Koriagina, Mariia

AU - Vasilkova, Daria

AU - Govorun, Vadim

AU - Dontsova, Olga

AU - Rubtsova, Maria

PY - 2021

DA - 2021/12/07

PB - Frontiers Media SA

VL - 9

SN - 2296-634X

ER -

BibTex |


doi = {10.3389/fcell.2021.754611},

url = {},

year = 2021,

month = {dec},

publisher = {Frontiers Media {SA}},

volume = {9},

author = {Viktoriia Shliapina and Mariia Koriagina and Daria Vasilkova and Vadim Govorun and Olga Dontsova and Maria Rubtsova},

title = {Human Telomerase {RNA} Protein Encoded by Telomerase {RNA} is Involved in Metabolic Responses},

journal = {Frontiers in Cell and Developmental Biology}


Shliapina, Viktoriia et al. “Human Telomerase RNA Protein Encoded by Telomerase RNA Is Involved in Metabolic Responses.” Frontiers in Cell and Developmental Biology 9 (2021): n. pag. Crossref. Web.