Open Access
,
volume 10
Synthesis methods of 1,2,3-/1,2,4-triazoles: A review
1
School of Pharmacy, China
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Publication type: Journal Article
Publication date: 2022-09-26
scimago Q1
wos Q2
SJR: 0.830
CiteScore: 8.4
Impact factor: 4.2
ISSN: 22962646
PubMed ID:
36226121
General Chemistry
Abstract
Triazole, comprising three nitrogen atoms and two carbon atoms, is divided into two isomers 1,2,3-triazole and 1,2,4-triazole. Compounds containing a triazole are one of the significant heterocycles that exhibit broad biological activities, such as antimicrobial, analgesic, anti-inflammatory, anticonvulsant, antineoplastic, antimalarial, antiviral, antiproliferative, and anticancer activities. A great quantity of drugs with a triazole structure has been developed and proved, for example, ketoconazole and fluconazole. Given the importance of the triazole scaffold, its synthesis has attracted much attention. This review summarizes the synthetic methods of triazole compounds from various nitrogen sources in the past 20 years.
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91
Total citations:
91
Citations from 2024:
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(78.03%)
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TY - JOUR
DO - 10.3389/fchem.2022.891484
UR - https://doi.org/10.3389/fchem.2022.891484
TI - Synthesis methods of 1,2,3-/1,2,4-triazoles: A review
T2 - Frontiers in Chemistry
AU - Dai, Jinlian
AU - Tian, Sen
AU - Yang, Xueqing
AU - Liu, Zongliang
PY - 2022
DA - 2022/09/26
PB - Frontiers Media S.A.
VL - 10
PMID - 36226121
SN - 2296-2646
ER -
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@article{2022_Dai,
author = {Jinlian Dai and Sen Tian and Xueqing Yang and Zongliang Liu},
title = {Synthesis methods of 1,2,3-/1,2,4-triazoles: A review},
journal = {Frontiers in Chemistry},
year = {2022},
volume = {10},
publisher = {Frontiers Media S.A.},
month = {sep},
url = {https://doi.org/10.3389/fchem.2022.891484},
doi = {10.3389/fchem.2022.891484}
}