Open Access

Frontiers in Immunology, volume 12

The Role of Macrophages in the Pathogenesis of SARS-CoV-2-Associated Acute Respiratory Distress Syndrome

Kosyreva Anna ^{1, 2}

Dzhalilova Dzhuliia ³

Lokhonina Anastasia ^{2, 4}

Vishnyakova Polina ^{2, 4}

Fatkhudinov Timur ^{2, 5}

Hide authors affiliations Show authors affiliations: 5 affiliations

Department of Neuromorphology, Science Research Institute of Human Morphology, Russia |

Histology Department, Peoples Friendship University of Russia (RUDN University), Russia |

Department of Immunomorphology of Inflammation, Science Research Institute of Human Morphology, Russia |

⁴

Department of Regenerative Medicine, National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, Russia |

⁵

Department of Growth and Development, Science Research Institute of Human Morphology, Russia |

Publication type: Journal Article

Publication date: 2021-05-10

Frontiers Media S.A.

Journal: Frontiers in Immunology

Quartile SCImago

Quartile WOS

Impact factor: 7.3

ISSN: 16643224

DOI: 10.3389/fimmu.2021.682871

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PubMed ID: 34040616

Immunology

Immunology and Allergy

Abstract

Macrophages are cells that mediate both innate and adaptive immunity reactions, playing a major role in both physiological and pathological processes. Systemic SARS-CoV-2-associated complications include acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation syndrome, edema, and pneumonia. These are predominantly effects of massive macrophage activation that collectively can be defined as macrophage activation syndrome. In this review we focus on the role of macrophages in COVID-19, as pathogenesis of the new coronavirus infection, especially in cases complicated by ARDS, largely depends on macrophage phenotypes and functionalities. We describe participation of monocytes, monocyte-derived and resident lung macrophages in SARS-CoV-2-associated ARDS and discuss possible utility of cell therapies for its treatment, notably the use of reprogrammed macrophages with stable pro- or anti-inflammatory phenotypes.

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Citations by journals

	1 2 3 4 5 6 7
Frontiers in Immunology	Frontiers in Immunology, 7, 11.48% Frontiers in Immunology 7 publications, 11.48%
Biomedicines	Biomedicines, 4, 6.56% Biomedicines 4 publications, 6.56%
PeerJ	PeerJ, 2, 3.28% PeerJ 2 publications, 3.28%
EBioMedicine	EBioMedicine, 2, 3.28% EBioMedicine 2 publications, 3.28%
Vaccines	Vaccines, 1, 1.64% Vaccines 1 publication, 1.64%
Journal of Inflammation Research	Journal of Inflammation Research, 1, 1.64% Journal of Inflammation Research 1 publication, 1.64%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 1, 1.64% Frontiers in Molecular Biosciences 1 publication, 1.64%
Journal of the American Heart Association	Journal of the American Heart Association, 1, 1.64% Journal of the American Heart Association 1 publication, 1.64%
Cells	Cells, 1, 1.64% Cells 1 publication, 1.64%
Life	Life, 1, 1.64% Life 1 publication, 1.64%
Genes	Genes, 1, 1.64% Genes 1 publication, 1.64%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 1, 1.64% Frontiers in Cell and Developmental Biology 1 publication, 1.64%
Journal of Clinical Medicine	Journal of Clinical Medicine, 1, 1.64% Journal of Clinical Medicine 1 publication, 1.64%
Drug Delivery and Translational Research	Drug Delivery and Translational Research, 1, 1.64% Drug Delivery and Translational Research 1 publication, 1.64%
Nature Immunology	Nature Immunology, 1, 1.64% Nature Immunology 1 publication, 1.64%
Critical Care	Critical Care, 1, 1.64% Critical Care 1 publication, 1.64%
Inflammation	Inflammation, 1, 1.64% Inflammation 1 publication, 1.64%
Nonlinear Dynamics	Nonlinear Dynamics, 1, 1.64% Nonlinear Dynamics 1 publication, 1.64%
Seminars in Immunopathology	Seminars in Immunopathology, 1, 1.64% Seminars in Immunopathology 1 publication, 1.64%
Frontiers in Medicine	Frontiers in Medicine, 1, 1.64% Frontiers in Medicine 1 publication, 1.64%
Cardiovascular Pathology	Cardiovascular Pathology, 1, 1.64% Cardiovascular Pathology 1 publication, 1.64%
Nuclear Medicine and Biology	Nuclear Medicine and Biology, 1, 1.64% Nuclear Medicine and Biology 1 publication, 1.64%
Life Sciences	Life Sciences, 1, 1.64% Life Sciences 1 publication, 1.64%
Clinical Immunology	Clinical Immunology, 1, 1.64% Clinical Immunology 1 publication, 1.64%
Molecular Therapy	Molecular Therapy, 1, 1.64% Molecular Therapy 1 publication, 1.64%
Clinical and Experimental Medicine	Clinical and Experimental Medicine, 1, 1.64% Clinical and Experimental Medicine 1 publication, 1.64%
Allergy: European Journal of Allergy and Clinical Immunology	Allergy: European Journal of Allergy and Clinical Immunology, 1, 1.64% Allergy: European Journal of Allergy and Clinical Immunology 1 publication, 1.64%
Advanced healthcare materials	Advanced healthcare materials, 1, 1.64% Advanced healthcare materials 1 publication, 1.64%
European Journal of Immunology	European Journal of Immunology, 1, 1.64% European Journal of Immunology 1 publication, 1.64%
	1 2 3 4 5 6 7

Citations by publishers

	2 4 6 8 10 12
Frontiers Media S.A.	Frontiers Media S.A., 11, 18.03% Frontiers Media S.A. 11 publications, 18.03%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 11, 18.03% Multidisciplinary Digital Publishing Institute (MDPI) 11 publications, 18.03%
Elsevier	Elsevier, 11, 18.03% Elsevier 11 publications, 18.03%
Wiley	Wiley, 9, 14.75% Wiley 9 publications, 14.75%
Springer Nature	Springer Nature, 8, 13.11% Springer Nature 8 publications, 13.11%
PeerJ	PeerJ, 2, 3.28% PeerJ 2 publications, 3.28%
Dove Medical Press	Dove Medical Press, 1, 1.64% Dove Medical Press 1 publication, 1.64%
Oxford University Press	Oxford University Press, 1, 1.64% Oxford University Press 1 publication, 1.64%
	2 4 6 8 10 12

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Kosyreva A. et al. The Role of Macrophages in the Pathogenesis of SARS-CoV-2-Associated Acute Respiratory Distress Syndrome // Frontiers in Immunology. 2021. Vol. 12.

GOST all authors (up to 50) Copy

Kosyreva A., Dzhalilova D., Lokhonina A., Vishnyakova P., Fatkhudinov T. The Role of Macrophages in the Pathogenesis of SARS-CoV-2-Associated Acute Respiratory Distress Syndrome // Frontiers in Immunology. 2021. Vol. 12.

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RIS Copy

TY - JOUR

DO - 10.3389/fimmu.2021.682871

UR - https://doi.org/10.3389%2Ffimmu.2021.682871

TI - The Role of Macrophages in the Pathogenesis of SARS-CoV-2-Associated Acute Respiratory Distress Syndrome

T2 - Frontiers in Immunology

AU - Kosyreva, Anna

AU - Dzhalilova, Dzhuliia

AU - Lokhonina, Anastasia

AU - Vishnyakova, Polina

AU - Fatkhudinov, Timur

PY - 2021

DA - 2021/05/10 00:00:00

PB - Frontiers Media S.A.

VL - 12

PMID - 34040616

SN - 1664-3224

ER -

BibTex

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BibTex Copy

@article{2021_Kosyreva,

author = {Anna Kosyreva and Dzhuliia Dzhalilova and Anastasia Lokhonina and Polina Vishnyakova and Timur Fatkhudinov},

title = {The Role of Macrophages in the Pathogenesis of SARS-CoV-2-Associated Acute Respiratory Distress Syndrome},

journal = {Frontiers in Immunology},

year = {2021},

volume = {12},

publisher = {Frontiers Media S.A.},

month = {may},

url = {https://doi.org/10.3389%2Ffimmu.2021.682871},

doi = {10.3389/fimmu.2021.682871}

}

Found error?

Publisher

Frontiers Media S.A.

Journal

Frontiers in Immunology

Quartile SCImago

Quartile WOS

Impact factor

7.3

ISSN

16643224 (Electronic)

Labs

Laboratory of Immunomorphology of Inflammation

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