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Agronomy, volume 13, issue 9, pages 2410

Green Waste from Cucumber (Cucumis sativus L.) Cultivation as a Source of Bioactive Flavonoids with Hypolipidemic Potential

Olennikov Daniil Nikolaevich ¹

Kashchenko Nina I ¹

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Laboratory of Biomedical Research, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, 6 Sakhyanovoy Street, Ulan-Ude 670047, Russia |

Publication type: Journal Article

Publication date: 2023-09-18

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Agronomy

Quartile SCImago

Quartile WOS

Impact factor: 3.7

ISSN: 20734395

DOI: 10.3390/agronomy13092410

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Agronomy and Crop Science

Abstract

Cucumber is an important agricultural crop that is cultivated under greenhouse conditions. Cucumber cultivation generates substantial quantities of green waste that require proper disposal. The lack of data on the chemical composition of cucumber greens and their biological activity emphasizes the necessity for research on useful products resulting from this widely available waste. Our examination of the flavonoid contents in the leaves and stems of 30 cucumber cultivars revealed 6 cultivars with high flavonoid contents. In addition, the cutting time did not cause negative effects, and we observed a positive effect with 0.05–0.10% organomineral fertilizer application on the flavonoid levels in the greens. Liquid chromatography–mass spectrometry detected 38 apigenin derivatives, including acylated and non-acylated cucumerins and C-, O-, and C,O-glycosides. Among these, 12 known flavonoids and 18 novel compounds were identified. The concentrations of these compounds in the six flavonoid extracts varied at 39.85–181.53 mg/g for the non-acylated flavones, 14.67–293.31 mg/g for the cucumerins, and 401.73–892.17 mg/g for the acylated flavones. Oral administration of the total flavonoid extracts (at a dosage of 100 g/kg/day) resulted in a hypolipidemic effect in hyperlipidemic hamsters, with subsequent normalization of their serum lipid profiles, malondialdehyde levels, and liver antioxidative enzyme activities. These results substantiate the lipid-lowering potential of cucumber waste extracts. Our investigation of the selected flavonoid activity showed that isovitexin-2′′-O-glucoside-6′′-O-p-coumarate (administered at 50 g/kg/day) had the highest hypolipidemic potency. These results can contribute to the practical use of cucumber green waste and the development of novel supplements for diseases linked to high-fat consumption.

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Chemistry of Natural Compounds	Chemistry of Natural Compounds, 1, 50% Chemistry of Natural Compounds 1 publication, 50%
Horticulturae	Horticulturae, 1, 50% Horticulturae 1 publication, 50%
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Springer Nature	Springer Nature, 1, 50% Springer Nature 1 publication, 50%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 50% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 50%
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Olennikov D. N., Kashchenko N. I. Green Waste from Cucumber (Cucumis sativus L.) Cultivation as a Source of Bioactive Flavonoids with Hypolipidemic Potential // Agronomy. 2023. Vol. 13. No. 9. p. 2410.

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TY - JOUR

DO - 10.3390/agronomy13092410

UR - https://doi.org/10.3390%2Fagronomy13092410

TI - Green Waste from Cucumber (Cucumis sativus L.) Cultivation as a Source of Bioactive Flavonoids with Hypolipidemic Potential

T2 - Agronomy

AU - Olennikov, Daniil Nikolaevich

AU - Kashchenko, Nina I

PY - 2023

DA - 2023/09/18 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 2410

IS - 9

VL - 13

SN - 2073-4395

ER -

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@article{2023_Olennikov,

author = {Daniil Nikolaevich Olennikov and Nina I Kashchenko},

title = {Green Waste from Cucumber (Cucumis sativus L.) Cultivation as a Source of Bioactive Flavonoids with Hypolipidemic Potential},

journal = {Agronomy},

year = {2023},

volume = {13},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {sep},

url = {https://doi.org/10.3390%2Fagronomy13092410},

number = {9},

pages = {2410},

doi = {10.3390/agronomy13092410}

}

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Olennikov, Daniil Nikolaevich, and Nina I Kashchenko. “Green Waste from Cucumber (Cucumis sativus L.) Cultivation as a Source of Bioactive Flavonoids with Hypolipidemic Potential.” Agronomy, vol. 13, no. 9, Sep. 2023, p. 2410. https://doi.org/10.3390%2Fagronomy13092410.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Agronomy

Quartile SCImago

Quartile WOS

Impact factor

3.7

ISSN

20734395 (Electronic)

Labs

Laboratory of Biomedical Research

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