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Biomedicines

, том 10 , издание 2 , страницы 274

Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates

Тип публикации: Journal Article

Дата публикации: 2022-01-26

MDPI

Biomedicines

scimago Q1

wos Q1

БС2

SJR: 1.114

CiteScore: 6.8

Impact factor: 3.9

ISSN: 22279059

DOI: 10.3390/biomedicines10020274

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PubMed ID: 35203484

General Biochemistry, Genetics and Molecular Biology

Medicine (miscellaneous)

Краткое описание

Non-alcoholic fatty liver disease (NAFLD), or metabolic (dysfunction)-associated fatty liver disease (MAFLD), is characterized by high global incidence and prevalence, a tight association with common metabolic comorbidities, and a substantial risk of progression and associated mortality. Despite the increasingly high medical and socioeconomic burden of NAFLD, the lack of approved pharmacotherapy regimens remains an unsolved issue. In this paper, we aimed to provide an update on the rapidly changing therapeutic landscape and highlight the major novel approaches to the treatment of this disease. In addition to describing the biomolecules and pathways identified as upcoming pharmacological targets for NAFLD, we reviewed the current status of drug discovery and development pipeline with a special focus on recent evidence from clinical trials.

Найдено

4 цитирования

Приходько Вероника

🤝

к.б.н.

60 публикаций, 223 цитирования

Индекс Хирша: 8

Санкт-Петербургский государственный химико-фармацевтический университет

Институт мозга человека имени Н. П. Бехтеревой РАН

4 цитирования

Оковитый Сергей

🤝

д.м.н., проф.

124 публикации, 601 цитирование, 1 рецензия

Индекс Хирша: 12

Санкт-Петербургский государственный химико-фармацевтический университет

Институт мозга человека имени Н. П. Бехтеревой РАН

Области научных интересов

Гепатология

Кардиология

Клиническая фармакология

Нейрофармакология

Фармакология

Экспериментальная медицина

1 цитирование

Ивкин Дмитрий

70 публикаций, 318 цитирований, 1 рецензия

Индекс Хирша: 10

Санкт-Петербургский государственный химико-фармацевтический университет

1 цитирование

Риты Джузеппе

69 публикаций, 2 789 цитирований, 95 рецензий

Индекс Хирша: 27

Неаполитанский университет имени Фридриха II

Университет Ванвителли

Топ-30

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Prikhodko V. A. et al. Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates // Biomedicines. 2022. Vol. 10. No. 2. p. 274.

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Prikhodko V. A., Bezborodkina N. N., Okovityi S. V. Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates // Biomedicines. 2022. Vol. 10. No. 2. p. 274.

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TY - JOUR

DO - 10.3390/biomedicines10020274

UR - https://doi.org/10.3390/biomedicines10020274

TI - Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates

T2 - Biomedicines

AU - Prikhodko, Veronika A.

AU - Bezborodkina, Natalia N.

AU - Okovityi, Sergey V.

PY - 2022

DA - 2022/01/26

PB - MDPI

SP - 274

IS - 2

VL - 10

PMID - 35203484

SN - 2227-9059

ER -

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@article{2022_Prikhodko,

author = {Veronika A. Prikhodko and Natalia N. Bezborodkina and Sergey V. Okovityi},

title = {Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates},

journal = {Biomedicines},

year = {2022},

volume = {10},

publisher = {MDPI},

month = {jan},

url = {https://doi.org/10.3390/biomedicines10020274},

number = {2},

pages = {274},

doi = {10.3390/biomedicines10020274}

}

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Prikhodko, Veronika A., et al. “Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates.” Biomedicines, vol. 10, no. 2, Jan. 2022, p. 274. https://doi.org/10.3390/biomedicines10020274.