Open Access

Biomedicines, volume 10, issue 2, pages 274

Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates

Prikhodko Veronika A. ¹

Bezborodkina Natalia N. ²

Okovityi Sergey V. ^{1, 3}

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Department of Pharmacology and Clinical Pharmacology, Saint Petersburg State Chemical and Pharmaceutical University, 14A Prof. Popov Str., 197022 St. Petersburg, Russia |

Zoological Institute, Russian Academy of Sciences, 1 Universitetskaya emb., 199034 St. Petersburg, Russia |

Scientific, Clinical and Educational Center of Gastroenterology and Hepatology, Saint Petersburg State University, 7/9 Universitetskaya emb., 199034 St. Petersburg, Russia |

Publication type: Journal Article

Publication date: 2022-01-26

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Biomedicines

Quartile SCImago

Quartile WOS

Impact factor: 4.7

ISSN: 22279059

DOI: 10.3390/biomedicines10020274

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General Biochemistry, Genetics and Molecular Biology

Medicine (miscellaneous)

Abstract

Non-alcoholic fatty liver disease (NAFLD), or metabolic (dysfunction)-associated fatty liver disease (MAFLD), is characterized by high global incidence and prevalence, a tight association with common metabolic comorbidities, and a substantial risk of progression and associated mortality. Despite the increasingly high medical and socioeconomic burden of NAFLD, the lack of approved pharmacotherapy regimens remains an unsolved issue. In this paper, we aimed to provide an update on the rapidly changing therapeutic landscape and highlight the major novel approaches to the treatment of this disease. In addition to describing the biomolecules and pathways identified as upcoming pharmacological targets for NAFLD, we reviewed the current status of drug discovery and development pipeline with a special focus on recent evidence from clinical trials.

By date By citations

Citations by journals

	1 2
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 8.33% International Journal of Molecular Sciences 2 publications, 8.33%
Medicina	Medicina, 2, 8.33% Medicina 2 publications, 8.33%
Experimental and Clinical Gastroenterology	Experimental and Clinical Gastroenterology, 2, 8.33% Experimental and Clinical Gastroenterology 2 publications, 8.33%
Livers	Livers, 1, 4.17% Livers 1 publication, 4.17%
Frontiers in Nutrition	Frontiers in Nutrition, 1, 4.17% Frontiers in Nutrition 1 publication, 4.17%
Frontiers in Immunology	Frontiers in Immunology, 1, 4.17% Frontiers in Immunology 1 publication, 4.17%
Signal Transduction and Targeted Therapy	Signal Transduction and Targeted Therapy, 1, 4.17% Signal Transduction and Targeted Therapy 1 publication, 4.17%
Antioxidants	Antioxidants, 1, 4.17% Antioxidants 1 publication, 4.17%
Scientific Reports	Scientific Reports, 1, 4.17% Scientific Reports 1 publication, 4.17%
Annals of Medicine and Surgery	Annals of Medicine and Surgery, 1, 4.17% Annals of Medicine and Surgery 1 publication, 4.17%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 1, 4.17% Biomedicine and Pharmacotherapy 1 publication, 4.17%
Heliyon	Heliyon, 1, 4.17% Heliyon 1 publication, 4.17%
Immunopharmacology and Immunotoxicology	Immunopharmacology and Immunotoxicology, 1, 4.17% Immunopharmacology and Immunotoxicology 1 publication, 4.17%
Life Sciences	Life Sciences, 1, 4.17% Life Sciences 1 publication, 4.17%
Biochimica et Biophysica Acta - Molecular Basis of Disease	Biochimica et Biophysica Acta - Molecular Basis of Disease, 1, 4.17% Biochimica et Biophysica Acta - Molecular Basis of Disease 1 publication, 4.17%
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy	Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 1, 4.17% Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 1 publication, 4.17%
Biomedicines	Biomedicines, 1, 4.17% Biomedicines 1 publication, 4.17%
Life	Life, 1, 4.17% Life 1 publication, 4.17%
Egyptian Liver Journal	Egyptian Liver Journal, 1, 4.17% Egyptian Liver Journal 1 publication, 4.17%
Frontiers in Endocrinology	Frontiers in Endocrinology, 1, 4.17% Frontiers in Endocrinology 1 publication, 4.17%
	1 2

Citations by publishers

	1 2 3 4 5 6 7 8
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 8, 33.33% Multidisciplinary Digital Publishing Institute (MDPI) 8 publications, 33.33%
Elsevier	Elsevier, 5, 20.83% Elsevier 5 publications, 20.83%
Frontiers Media S.A.	Frontiers Media S.A., 3, 12.5% Frontiers Media S.A. 3 publications, 12.5%
Springer Nature	Springer Nature, 3, 12.5% Springer Nature 3 publications, 12.5%
Gastroenterological Scientific Society of Russia	Gastroenterological Scientific Society of Russia, 2, 8.33% Gastroenterological Scientific Society of Russia 2 publications, 8.33%
Taylor & Francis	Taylor & Francis, 1, 4.17% Taylor & Francis 1 publication, 4.17%
Dove Medical Press	Dove Medical Press, 1, 4.17% Dove Medical Press 1 publication, 4.17%
	1 2 3 4 5 6 7 8

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Prikhodko V. A. et al. Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates // Biomedicines. 2022. Vol. 10. No. 2. p. 274.

GOST all authors (up to 50) Copy

Prikhodko V. A., Bezborodkina N. N., Okovityi S. V. Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates // Biomedicines. 2022. Vol. 10. No. 2. p. 274.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/biomedicines10020274

UR - https://doi.org/10.3390%2Fbiomedicines10020274

TI - Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates

T2 - Biomedicines

AU - Bezborodkina, Natalia N.

AU - Prikhodko, Veronika A.

AU - Okovityi, Sergey V.

PY - 2022

DA - 2022/01/26 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 274

IS - 2

VL - 10

SN - 2227-9059

ER -

BibTex |

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BibTex Copy

@article{2022_Prikhodko,

author = {Natalia N. Bezborodkina and Veronika A. Prikhodko and Sergey V. Okovityi},

title = {Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates},

journal = {Biomedicines},

year = {2022},

volume = {10},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {jan},

url = {https://doi.org/10.3390%2Fbiomedicines10020274},

number = {2},

pages = {274},

doi = {10.3390/biomedicines10020274}

}

MLA

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Prikhodko, Veronika A., et al. “Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates.” Biomedicines, vol. 10, no. 2, Jan. 2022, p. 274. https://doi.org/10.3390%2Fbiomedicines10020274.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Biomedicines

Quartile SCImago

Quartile WOS

Impact factor

4.7

ISSN

22279059 (Electronic)

Labs

Department of Pharmacology and Clinical Pharmacology

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