Open Access

Biomedicines

, volume 10 , issue 2 , pages 274

Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates

Veronika A. Prikhodko ¹

Natalia N. Bezborodkina ²

Sergey V. Okovityi ^{1, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Pharmacology and Clinical Pharmacology, Saint Petersburg State Chemical and Pharmaceutical University, 14A Prof. Popov Str., 197022 St. Petersburg, Russia |

Zoological Institute, Russian Academy of Sciences, 1 Universitetskaya emb., 199034 St. Petersburg, Russia |

Scientific, Clinical and Educational Center of Gastroenterology and Hepatology, Saint Petersburg State University, 7/9 Universitetskaya emb., 199034 St. Petersburg, Russia |

Publication type: Journal Article

Publication date: 2022-01-26

MDPI

Biomedicines

scimago Q1

wos Q1

SJR: 1.114

CiteScore: 6.8

Impact factor: 3.9

ISSN: 22279059

DOI: 10.3390/biomedicines10020274

Copy DOI

PubMed ID: 35203484

General Biochemistry, Genetics and Molecular Biology

Medicine (miscellaneous)

Abstract

Non-alcoholic fatty liver disease (NAFLD), or metabolic (dysfunction)-associated fatty liver disease (MAFLD), is characterized by high global incidence and prevalence, a tight association with common metabolic comorbidities, and a substantial risk of progression and associated mortality. Despite the increasingly high medical and socioeconomic burden of NAFLD, the lack of approved pharmacotherapy regimens remains an unsolved issue. In this paper, we aimed to provide an update on the rapidly changing therapeutic landscape and highlight the major novel approaches to the treatment of this disease. In addition to describing the biomolecules and pathways identified as upcoming pharmacological targets for NAFLD, we reviewed the current status of drug discovery and development pipeline with a special focus on recent evidence from clinical trials.

Found

4 citations

Prikhodko Veronika

🤝

PhD in Biological/biomedical sciences

59 publications, 210 citations

h-index: 7

Saint-Petersburg State Chemical and Pharmaceutical University

N. P. Bechtereva Institute of the Human Brain of Russian Academy of Sciences

4 citations

Okovityi Sergey

🤝

DSc in Health sciences, professor

122 publications, 581 citations, 1 review

h-index: 12

Saint-Petersburg State Chemical and Pharmaceutical University

N. P. Bechtereva Institute of the Human Brain of Russian Academy of Sciences

Research interests

Cardiology

Clinical pharmacology

Experimental medicine

Hepatology

Neuropharmacology

Pharmacology

1 citation

Ivkin Dmitry

69 publications, 302 citations, 1 review

h-index: 10

Saint-Petersburg State Chemical and Pharmaceutical University

1 citation

Annunziata Giuseppe

68 publications, 2 692 citations, 95 reviews

h-index: 27

University of Naples Federico II

University of Campania "Luigi Vanvitelli"

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GOST |

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GOST Copy

Prikhodko V. A. et al. Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates // Biomedicines. 2022. Vol. 10. No. 2. p. 274.

GOST all authors (up to 50) Copy

Prikhodko V. A., Bezborodkina N. N., Okovityi S. V. Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates // Biomedicines. 2022. Vol. 10. No. 2. p. 274.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.3390/biomedicines10020274

UR - https://doi.org/10.3390/biomedicines10020274

TI - Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates

T2 - Biomedicines

AU - Prikhodko, Veronika A.

AU - Bezborodkina, Natalia N.

AU - Okovityi, Sergey V.

PY - 2022

DA - 2022/01/26

PB - MDPI

SP - 274

IS - 2

VL - 10

PMID - 35203484

SN - 2227-9059

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Prikhodko,

author = {Veronika A. Prikhodko and Natalia N. Bezborodkina and Sergey V. Okovityi},

title = {Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates},

journal = {Biomedicines},

year = {2022},

volume = {10},

publisher = {MDPI},

month = {jan},

url = {https://doi.org/10.3390/biomedicines10020274},

number = {2},

pages = {274},

doi = {10.3390/biomedicines10020274}

}

MLA

Cite this

MLA Copy

Prikhodko, Veronika A., et al. “Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates.” Biomedicines, vol. 10, no. 2, Jan. 2022, p. 274. https://doi.org/10.3390/biomedicines10020274.

Publisher

MDPI

Journal

Biomedicines

scimago Q1

wos Q1

SJR

1.114

CiteScore

6.8

Impact factor

3.9

ISSN

22279059 (Electronic)

Labs

Department of Pharmacology and Clinical Pharmacology

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