Open Access
Biomedicines, volume 8, issue 10, pages 428
Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics
Publication type: Journal Article
Publication date: 2020-10-18
PubMed ID:
33080959
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Abstract
Hypoxia plays an important role in the development of many infectious, inflammatory, and tumor diseases. The predisposition to such disorders is mostly provided by differences in basic tolerance to oxygen deficiency, which we discuss in this review. Except the direct exposure of different-severity hypoxia in decompression chambers or in highland conditions, there are no alternative methods for determining organism tolerance. Due to the variability of the detection methods, differences in many parameters between tolerant and susceptible organisms are still not well-characterized, but some of them can serve as biomarkers of susceptibility to hypoxia. At the moment, several potential biomarkers in conditions after hypoxic exposure have been identified both in experimental animals and humans. The main potential biomarkers are Hypoxia-Inducible Factor (HIF)-1, Heat-Shock Protein 70 (HSP70), and NO. Due to the different mechanisms of various high-altitude diseases, biomarkers may not be highly specific and universal. Therefore, it is extremely important to conduct research on hypoxia susceptibility biomarkers. Moreover, it is important to develop a method for the evaluation of organisms’ basic hypoxia tolerance without the necessity of any oxygen deficiency exposure. This can contribute to new personalized medicine approaches’ development for diagnostics and the treatment of inflammatory and tumor diseases, taking into account hypoxia tolerance differences.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Dzhalilova D., Makarova O. Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics // Biomedicines. 2020. Vol. 8. No. 10. p. 428.
GOST all authors (up to 50)
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Dzhalilova D., Makarova O. Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics // Biomedicines. 2020. Vol. 8. No. 10. p. 428.
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TY - JOUR
DO - 10.3390/biomedicines8100428
UR - https://doi.org/10.3390%2Fbiomedicines8100428
TI - Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics
T2 - Biomedicines
AU - Makarova, Olga
AU - Dzhalilova, Dzhuliia
PY - 2020
DA - 2020/10/18 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 428
IS - 10
VL - 8
PMID - 33080959
SN - 2227-9059
ER -
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@article{2020_Dzhalilova,
author = {Olga Makarova and Dzhuliia Dzhalilova},
title = {Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics},
journal = {Biomedicines},
year = {2020},
volume = {8},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {oct},
url = {https://doi.org/10.3390%2Fbiomedicines8100428},
number = {10},
pages = {428},
doi = {10.3390/biomedicines8100428}
}
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MLA
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Dzhalilova, Dzhuliia, and Olga Makarova. “Differences in Tolerance to Hypoxia: Physiological, Biochemical, and Molecular-Biological Characteristics.” Biomedicines, vol. 8, no. 10, Oct. 2020, p. 428. https://doi.org/10.3390%2Fbiomedicines8100428.
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