Open Access
Brain Sciences, volume 10, issue 5, pages 311
Glutamatergic Fate of Neural Progenitor Cells of Rats with Inherited Audiogenic Epilepsy
Publication type: Journal Article
Publication date: 2020-05-21
General Neuroscience
Abstract
Epilepsy is associated with aberrant neurogenesis in the hippocampus and may underlie the development of hereditary epilepsy. In the present study, we analyzed the differentiation fate of neural progenitor cells (NPC), which were isolated from the hippocampus of embryos of Krushinsky-Molodkina (KM) rats genetically prone to audiogenic epilepsy. NPCs from embryos of Wistar rats were used as the control. We found principal differences between Wistar and KM NPC in unstimulated controls: Wistar NPC culture contained both gamma-aminobutyric acid (GABA) and glutamatergic neurons; KM NPC culture was mainly represented by glutamatergic cells. The stimulation of glutamatergic differentiation of Wistar NPC resulted in a significant increase in glutamatergic cell number that was accompanied by the activation of protein kinase A. The stimulation of KM NPC led to a decrease in immature glutamatergic cell number and was associated with the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and protein kinase B/ glycogen synthase kinase 3 beta (Akt/GSK3β), which indicates the activation of glutamatergic cell maturation. These results suggest genetically programmed abnormalities in KM rats that determine the glutamatergic fate of NPC and contribute to the development of audiogenic epilepsy.
Citations by journals
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1
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Child's Nervous System
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Child's Nervous System
1 publication, 25%
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Neuroscience Letters
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Neuroscience Letters
1 publication, 25%
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Epilepsy and Behavior
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Epilepsy and Behavior
1 publication, 25%
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Epilepsy and Paroxysmal Conditions
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Epilepsy and Paroxysmal Conditions, 1, 25%
Epilepsy and Paroxysmal Conditions
1 publication, 25%
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1
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Citations by publishers
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2
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Elsevier
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Elsevier
2 publications, 50%
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Springer Nature
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Springer Nature
1 publication, 25%
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IRBIS
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IRBIS, 1, 25%
IRBIS
1 publication, 25%
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1
2
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- We do not take into account publications that without a DOI.
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Naumova A. A. et al. Glutamatergic Fate of Neural Progenitor Cells of Rats with Inherited Audiogenic Epilepsy // Brain Sciences. 2020. Vol. 10. No. 5. p. 311.
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Naumova A. A., Oleynik E. A., Chernigovskaya E. V., Glazova M. V. Glutamatergic Fate of Neural Progenitor Cells of Rats with Inherited Audiogenic Epilepsy // Brain Sciences. 2020. Vol. 10. No. 5. p. 311.
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TY - JOUR
DO - 10.3390/brainsci10050311
UR - https://doi.org/10.3390%2Fbrainsci10050311
TI - Glutamatergic Fate of Neural Progenitor Cells of Rats with Inherited Audiogenic Epilepsy
T2 - Brain Sciences
AU - Naumova, Alexandra A
AU - Oleynik, Ekaterina A
AU - Chernigovskaya, Elena V.
AU - Glazova, M. V.
PY - 2020
DA - 2020/05/21 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 311
IS - 5
VL - 10
SN - 2076-3425
ER -
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@article{2020_Naumova,
author = {Alexandra A Naumova and Ekaterina A Oleynik and Elena V. Chernigovskaya and M. V. Glazova},
title = {Glutamatergic Fate of Neural Progenitor Cells of Rats with Inherited Audiogenic Epilepsy},
journal = {Brain Sciences},
year = {2020},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Fbrainsci10050311},
number = {5},
pages = {311},
doi = {10.3390/brainsci10050311}
}
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Naumova, Alexandra A., et al. “Glutamatergic Fate of Neural Progenitor Cells of Rats with Inherited Audiogenic Epilepsy.” Brain Sciences, vol. 10, no. 5, May. 2020, p. 311. https://doi.org/10.3390%2Fbrainsci10050311.
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