Open Access
Cells, volume 11, issue 13, pages 1991
Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination
Astakhova Ekaterina A
1, 2
,
Byazrova Maria G
1, 2, 3
,
Yusubalieva Gaukhar M
4
,
Kulemzin Sergey V
5
,
Prilipov Alexey G
1, 7
,
Baklaushev Vladimir P.
4
,
Filatov A V
1, 2
Publication type: Journal Article
Publication date: 2022-06-21
PubMed ID:
35805076
General Medicine
Abstract
Both SARS-CoV-2 infection and vaccination have previously been demonstrated to elicit robust, yet somewhat limited immunity against the evolving variants of SARS-CoV-2. Nevertheless, reports performing side-by-side comparison of immune responses following infection vs. vaccination have been relatively scarce. The aim of this study was to compare B-cell response to adenovirus-vectored vaccination in SARS-CoV-2-naive individuals with that observed in the COVID-19 convalescent patients six months after the first encounter with the viral antigens. We set out to use a single analytical platform and performed comprehensive analysis of serum levels of receptor binding domain (RBD)-specific and virus-neutralizing antibodies, frequencies of RBD-binding circulating memory B cells (MBCs), MBC-derived antibody-secreting cells, as well as RBD-specific and virus-neutralizing activity of MBC-derived antibodies after Gam-COVID-Vac (Sputnik V) vaccination and/or natural SARS-CoV-2 infection. Overall, natural immunity was superior to Gam-COVID-Vac vaccination. The levels of neutralizing MBC-derived antibodies in the convalescent patients turned out to be significantly higher than those found following vaccination. Our results suggest that after six months, SARS-CoV-2-specific MBC immunity is more robust in COVID-19 convalescent patients than in Gam-COVID-Vac recipients. Collectively, our data unambiguously indicate that natural immunity outperforms Gam-COVID-Vac-induced immunity six months following recovery/vaccination, which should inform healthcare and vaccination decisions.
Citations by journals
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Vaccines
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Vaccines
2 publications, 40%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 20%
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Scientific Reports
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Scientific Reports
1 publication, 20%
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Microorganisms
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Microorganisms
1 publication, 20%
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1
2
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Citations by publishers
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1
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4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 80%
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Springer Nature
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Springer Nature
1 publication, 20%
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1
2
3
4
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Astakhova E. A. et al. Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination // Cells. 2022. Vol. 11. No. 13. p. 1991.
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Astakhova E. A., Byazrova M. G., Yusubalieva G. M., Kulemzin S. V., Kruglova N. S., Prilipov A. G., Baklaushev V. P., Gorchakov A. A., Taranin A., Filatov A. V. Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination // Cells. 2022. Vol. 11. No. 13. p. 1991.
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TY - JOUR
DO - 10.3390/cells11131991
UR - https://doi.org/10.3390%2Fcells11131991
TI - Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination
T2 - Cells
AU - Astakhova, Ekaterina A
AU - Byazrova, Maria G
AU - Yusubalieva, Gaukhar M
AU - Kulemzin, Sergey V
AU - Prilipov, Alexey G
AU - Baklaushev, Vladimir P.
AU - Kruglova, Natal’ya S.
AU - Gorchakov, Andrey A
AU - Taranin, Alexander
AU - Filatov, A V
PY - 2022
DA - 2022/06/21 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1991
IS - 13
VL - 11
PMID - 35805076
SN - 2073-4409
ER -
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@article{2022_Astakhova,
author = {Ekaterina A Astakhova and Maria G Byazrova and Gaukhar M Yusubalieva and Sergey V Kulemzin and Alexey G Prilipov and Vladimir P. Baklaushev and Natal’ya S. Kruglova and Andrey A Gorchakov and Alexander Taranin and A V Filatov},
title = {Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination},
journal = {Cells},
year = {2022},
volume = {11},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fcells11131991},
number = {13},
pages = {1991},
doi = {10.3390/cells11131991}
}
Cite this
MLA
Copy
Astakhova, Ekaterina A., et al. “Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination.” Cells, vol. 11, no. 13, Jun. 2022, p. 1991. https://doi.org/10.3390%2Fcells11131991.