Open Access
Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties
Paola Baker
1
,
Christina Huang
1, 2
,
Rakan Radi
1
,
Samara B. Moll
1
,
Emmanuela Jules
1
,
Jack Arbiser
3
3
Metroderm/United Derm Partners, 875 Johnson Ferry Road, Atlanta, GA 30342, USA
|
Publication type: Journal Article
Publication date: 2023-11-30
PubMed ID:
38067173
General Medicine
Abstract
An intact barrier function of the skin is important in maintaining skin health. The regulation of the skin barrier depends on a multitude of molecular and immunological signaling pathways. By examining the regulation of a healthy skin barrier, including maintenance of the acid mantle and appropriate levels of ceramides, dermatologists can better formulate solutions to address issues that are related to a disrupted skin barrier. Conversely, by understanding specific skin barrier disruptions that are associated with specific conditions, such as atopic dermatitis or psoriasis, the development of new compounds could target signaling pathways to provide more effective relief for patients. We aim to review key factors mediating skin barrier regulation and inflammation, including skin acidity, interleukins, nuclear factor kappa B, and sirtuin 3. Furthermore, we will discuss current and emerging treatment options for skin barrier conditions.
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Metrics
90
Total citations:
90
Citations from 2024:
84
(96.55%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Baker P. et al. Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties // Cells. 2023. Vol. 12. No. 23. p. 2745.
GOST all authors (up to 50)
Copy
Baker P., Huang C., Radi R., Moll S. B., Jules E., Arbiser J. Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties // Cells. 2023. Vol. 12. No. 23. p. 2745.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/cells12232745
UR - https://doi.org/10.3390/cells12232745
TI - Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties
T2 - Cells
AU - Baker, Paola
AU - Huang, Christina
AU - Radi, Rakan
AU - Moll, Samara B.
AU - Jules, Emmanuela
AU - Arbiser, Jack
PY - 2023
DA - 2023/11/30
PB - MDPI
SP - 2745
IS - 23
VL - 12
PMID - 38067173
SN - 2073-4409
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Baker,
author = {Paola Baker and Christina Huang and Rakan Radi and Samara B. Moll and Emmanuela Jules and Jack Arbiser},
title = {Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties},
journal = {Cells},
year = {2023},
volume = {12},
publisher = {MDPI},
month = {nov},
url = {https://doi.org/10.3390/cells12232745},
number = {23},
pages = {2745},
doi = {10.3390/cells12232745}
}
Cite this
MLA
Copy
Baker, Paola, et al. “Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties.” Cells, vol. 12, no. 23, Nov. 2023, p. 2745. https://doi.org/10.3390/cells12232745.