Aneuploidy and DNA Methylation as Mirrored Features of Early Human Embryo Development
Genome stability is an integral feature of all living organisms. Aneuploidy is the most common cause of fetal death in humans. The timing of bursts in increased aneuploidy frequency coincides with the waves of global epigenetic reprogramming in mammals. During gametogenesis and early embryogenesis, parental genomes undergo two waves of DNA methylation reprogramming. Failure of these processes can critically affect genome stability, including chromosome segregation during cell division. Abnormal methylation due to errors in the reprogramming process can potentially lead to aneuploidy. On the other hand, the presence of an entire additional chromosome, or chromosome loss, can affect the global genome methylation level. The associations of these two phenomena are well studied in the context of carcinogenesis, but here, we consider the relationship of DNA methylation and aneuploidy in early human and mammalian ontogenesis. In this review, we link these two phenomena and highlight the critical ontogenesis periods and genome regions that play a significant role in human reproduction and in the formation of pathological phenotypes in newborns with chromosomal aneuploidy.
Citations by journals
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Scientific Reports
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Scientific Reports
3 publications, 27.27%
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Journal of Assisted Reproduction and Genetics
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Journal of Assisted Reproduction and Genetics
2 publications, 18.18%
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Genes
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Genes
1 publication, 9.09%
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Journal of Personalized Medicine
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Journal of Personalized Medicine
1 publication, 9.09%
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Clinical Epigenetics
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Clinical Epigenetics
1 publication, 9.09%
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G3: Genes, Genomes, Genetics
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G3: Genes, Genomes, Genetics
1 publication, 9.09%
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Frontiers in Genetics
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Frontiers in Genetics
1 publication, 9.09%
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Citations by publishers
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Springer Nature
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Springer Nature
6 publications, 54.55%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 18.18%
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Genetics Society of America
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Genetics Society of America
1 publication, 9.09%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 9.09%
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