Open Access
International Journal of Molecular Sciences, volume 20, issue 4, pages 823
Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration
Nimiritsky Peter
1, 2
,
Eremichev Roman
1
,
Alexandrushkina Natalya
1, 2
,
Efimenko Anastasia
1, 2
,
Tkachuk Vsevolod
1, 2, 3
,
Makarevich Pavel I
1, 2
Publication type: Journal Article
Publication date: 2019-02-14
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Regeneration is a fundamental process attributed to the functions of adult stem cells. In the last decades, delivery of suspended adult stem cells is widely adopted in regenerative medicine as a leading means of cell therapy. However, adult stem cells cannot complete the task of human body regeneration effectively by themselves as far as they need a receptive microenvironment (the niche) to engraft and perform properly. Understanding the mechanisms underlying mammalian regeneration leads us to an assumption that improved outcomes of cell therapy require a specific microenvironment that is generated in damaged areas prior to stem cell delivery. To a certain extent, it may be achieved by the delivery of mesenchymal stromal cells (MSCs), not in dispersed form, but rather in self-organized cell sheets (CS) – tissue-like structures comprised of viable cells and microenvironment components: extracellular matrix and soluble factors deposited in the matrix. In this review, we highlight the potential role of MSCs as regeneration organizers and speculate that this function emerges in CS. This concept shifts our understanding of the therapeutic mechanism underlying a widely known CS-based delivery method for regenerative medicine.
Citations by journals
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International Journal of Molecular Sciences
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4 publications, 16.67%
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1 publication, 4.17%
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Biocell
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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1 publication, 4.17%
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Russian Journal of Developmental Biology
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1 publication, 4.17%
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Lecture Notes in Networks and Systems
1 publication, 4.17%
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Scientific Reports
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Scientific Reports
1 publication, 4.17%
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Citations by publishers
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Springer Nature
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Springer Nature
6 publications, 25%
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Multidisciplinary Digital Publishing Institute (MDPI)
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6 publications, 25%
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Frontiers Media S.A.
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6 publications, 25%
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Pleiades Publishing
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Pleiades Publishing
2 publications, 8.33%
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First Pavlov State Medical University of St. Petersburg
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First Pavlov State Medical University of St. Petersburg
1 publication, 4.17%
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American Society for Pharmacology and Experimental Therapeutics
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1 publication, 4.17%
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Tech Science Press
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Tech Science Press, 1, 4.17%
Tech Science Press
1 publication, 4.17%
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Elsevier
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Elsevier
1 publication, 4.17%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nimiritsky P. et al. Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration // International Journal of Molecular Sciences. 2019. Vol. 20. No. 4. p. 823.
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Nimiritsky P., Eremichev R., Alexandrushkina N., Efimenko A., Tkachuk V., Makarevich P. I. Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration // International Journal of Molecular Sciences. 2019. Vol. 20. No. 4. p. 823.
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TY - JOUR
DO - 10.3390/ijms20040823
UR - https://doi.org/10.3390%2Fijms20040823
TI - Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration
T2 - International Journal of Molecular Sciences
AU - Nimiritsky, Peter
AU - Eremichev, Roman
AU - Alexandrushkina, Natalya
AU - Efimenko, Anastasia
AU - Tkachuk, Vsevolod
AU - Makarevich, Pavel I
PY - 2019
DA - 2019/02/14 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 823
IS - 4
VL - 20
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2019_Nimiritsky,
author = {Peter Nimiritsky and Roman Eremichev and Natalya Alexandrushkina and Anastasia Efimenko and Vsevolod Tkachuk and Pavel I Makarevich},
title = {Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration},
journal = {International Journal of Molecular Sciences},
year = {2019},
volume = {20},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {feb},
url = {https://doi.org/10.3390%2Fijms20040823},
number = {4},
pages = {823},
doi = {10.3390/ijms20040823}
}
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MLA
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Nimiritsky, Peter, et al. “Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration.” International Journal of Molecular Sciences, vol. 20, no. 4, Feb. 2019, p. 823. https://doi.org/10.3390%2Fijms20040823.