Open Access
International Journal of Molecular Sciences, volume 20, issue 12, pages 3070
Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary
Publication type: Journal Article
Publication date: 2019-06-23
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
31234589
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
The origin of serotonin in the ovary is the key question for understanding mechanisms of serotonergic regulation of reproductive function. We performed a study of the expression and functional activity of the serotonin transporter (SERT) and the enzyme for the synthesis of serotonin, aromatic l-amino acid decarboxylase (DDC) in mouse ovary. A pronounced peak of SERT mRNA expression occurs at the age of 14 days, but serotonin synthesis enzymes are expressed at the maximum level in the ovaries of newborn mice. SERT is detected immunohistochemically in all cellular compartments of the ovary with a maximum level of immunostaining in the oocytes of growing ovarian follicles. DDC immunolocalization, in contrast, is detected to a greater extent in primordial follicle oocytes, and decreases at the later stages of folliculogenesis. Serotonin synthesis in all cellular compartments occurs at very low levels, whereas specific serotonin uptake is clearly present, leading to a significant increase in serotonin content in the oocytes of growing primary and secondary follicles. These data indicate that the main mechanism of serotonin accumulation in mouse ovary is its uptake by the specific SERT membrane transporter, which is active in the oocytes of the growing ovarian follicles.
Citations by journals
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International Journal of Molecular Sciences
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3 publications, 27.27%
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Citations by publishers
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4
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Multidisciplinary Digital Publishing Institute (MDPI)
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4 publications, 36.36%
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Springer Nature
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2 publications, 18.18%
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Pleiades Publishing
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2 publications, 18.18%
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IOS Press
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1 publication, 9.09%
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Wiley
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1 publication, 9.09%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Nikishin D. A. et al. Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary // International Journal of Molecular Sciences. 2019. Vol. 20. No. 12. p. 3070.
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Nikishin D. A., Alyoshina N. M., Semenova M. L., Shmukler Y. B. Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary // International Journal of Molecular Sciences. 2019. Vol. 20. No. 12. p. 3070.
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TY - JOUR
DO - 10.3390/ijms20123070
UR - https://doi.org/10.3390%2Fijms20123070
TI - Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary
T2 - International Journal of Molecular Sciences
AU - Alyoshina, Nina M
AU - Semenova, Maria L
AU - Shmukler, Yuri B
AU - Nikishin, Denis A
PY - 2019
DA - 2019/06/23 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 3070
IS - 12
VL - 20
PMID - 31234589
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2019_Nikishin,
author = {Nina M Alyoshina and Maria L Semenova and Yuri B Shmukler and Denis A Nikishin},
title = {Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary},
journal = {International Journal of Molecular Sciences},
year = {2019},
volume = {20},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fijms20123070},
number = {12},
pages = {3070},
doi = {10.3390/ijms20123070}
}
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MLA
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Nikishin, Denis A., et al. “Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary.” International Journal of Molecular Sciences, vol. 20, no. 12, Jun. 2019, p. 3070. https://doi.org/10.3390%2Fijms20123070.