Open Access
International Journal of Molecular Sciences, volume 23, issue 4, pages 2387
Pro- and Anti-Inflammatory Cytokines in the Context of NK Cell–Trophoblast Interactions
Mikhailova Valentina
1, 2
,
Davydova Alina
1
,
Salloum Zeina
1
,
Zagainova Valeria
3
,
Markova Kseniia
1
,
Kogan Igor
3
,
Selkov Sergey
1, 2
,
Sokolov Dmitry I.
1, 2
Publication type: Journal Article
Publication date: 2022-02-21
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
35216502
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
During pregnancy, uterine NK cells interact with trophoblast cells. In addition to contact interactions, uterine NK cells are influenced by cytokines, which are secreted by the cells of the decidua microenvironment. Cytokines can affect the phenotypic characteristics of NK cells and change their functional activity. An imbalance of pro- and anti-inflammatory signals can lead to the development of reproductive pathology. The aim of this study was to assess the effects of cytokines on NK cells in the presence of trophoblast cells in an in vitro model. We used TNFα, IFNγ, TGFβ and IL-10; the NK-92 cell line; and peripheral blood NK cells (pNKs) from healthy, non-pregnant women. For trophoblast cells, the JEG-3 cell line was used. In the monoculture of NK-92 cells, TNFα caused a decrease in CD56 expression. In the coculture of NK cells with JEG-3 cells, TNFα increased the expression of NKG2C and NKG2A by NK-92 cells. Under the influence of TGFβ, the expression of CD56 increased and the expression of NKp30 decreased in the monoculture. After the preliminary cultivation of NK-92 cells in the presence of TGFβ, their cytotoxicity increased. In the case of adding TGFβ to the PBMC culture, as well as coculturing PBMCs and JEG-3 cells, the expression of CD56 and NKp44 by pNK cells was reduced. The differences in the effects of TGFβ in the model using NK-92 cells and pNK cells may be associated with the possible influence of monocytes or other lymphoid cells from the mononuclear fraction.
Citations by journals
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Citations by publishers
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1
2
3
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Multidisciplinary Digital Publishing Institute (MDPI)
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3 publications, 37.5%
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Elsevier
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1 publication, 12.5%
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Wiley
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1 publication, 12.5%
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Pleiades Publishing
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1 publication, 12.5%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 12.5%
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1
2
3
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Mikhailova V. et al. Pro- and Anti-Inflammatory Cytokines in the Context of NK Cell–Trophoblast Interactions // International Journal of Molecular Sciences. 2022. Vol. 23. No. 4. p. 2387.
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Mikhailova V., Grebenkina P., Khokhlova E., Davydova A., Salloum Z., Tyshchuk E., Zagainova V., Markova K., Kogan I., Selkov S., Sokolov D. I. Pro- and Anti-Inflammatory Cytokines in the Context of NK Cell–Trophoblast Interactions // International Journal of Molecular Sciences. 2022. Vol. 23. No. 4. p. 2387.
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TY - JOUR
DO - 10.3390/ijms23042387
UR - https://doi.org/10.3390%2Fijms23042387
TI - Pro- and Anti-Inflammatory Cytokines in the Context of NK Cell–Trophoblast Interactions
T2 - International Journal of Molecular Sciences
AU - Grebenkina, Polina
AU - Khokhlova, Evgeniia
AU - Davydova, Alina
AU - Salloum, Zeina
AU - Zagainova, Valeria
AU - Kogan, Igor
AU - Selkov, Sergey
AU - Mikhailova, Valentina
AU - Tyshchuk, Elizaveta
AU - Markova, Kseniia
AU - Sokolov, Dmitry I.
PY - 2022
DA - 2022/02/21 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 2387
IS - 4
VL - 23
PMID - 35216502
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2022_Mikhailova,
author = {Polina Grebenkina and Evgeniia Khokhlova and Alina Davydova and Zeina Salloum and Valeria Zagainova and Igor Kogan and Sergey Selkov and Valentina Mikhailova and Elizaveta Tyshchuk and Kseniia Markova and Dmitry I. Sokolov},
title = {Pro- and Anti-Inflammatory Cytokines in the Context of NK Cell–Trophoblast Interactions},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {feb},
url = {https://doi.org/10.3390%2Fijms23042387},
number = {4},
pages = {2387},
doi = {10.3390/ijms23042387}
}
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MLA
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Mikhailova, Valentina, et al. “Pro- and Anti-Inflammatory Cytokines in the Context of NK Cell–Trophoblast Interactions.” International Journal of Molecular Sciences, vol. 23, no. 4, Feb. 2022, p. 2387. https://doi.org/10.3390%2Fijms23042387.