Open Access
International Journal of Molecular Sciences, volume 24, issue 2, pages 1133
Functionalized Magnetite Nanoparticles: Characterization, Bioeffects, and Role of Reactive Oxygen Species in Unicellular and Enzymatic Systems
Kicheeva Arina G
1
,
Kovel Ekaterina S
1, 2
,
Pankratov D. A.
4
,
Tropskaya Nataliya S
3, 5
,
Dzeranov Artur
3, 5
,
Dzhardimalieva G I
3, 6
,
Zarrelli Mauro
7
,
Kudryasheva N.
1, 8
7
Institute for Polymers, Composites and Biomaterials, National Research Council of Italy, P.le Fermi, 1, 80055 Portici, Italy
|
Publication type: Journal Article
Publication date: 2023-01-06
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
36674650
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
The current study evaluates the role of reactive oxygen species (ROS) in bioeffects of magnetite nanoparticles (MNPs), such as bare (Fe3O4), humic acids (Fe3O4-HA), and 3-aminopropyltriethoxysilane (Fe3O4-APTES) modified MNPs. Mössbauer spectroscopy was used to identify the local surrounding for Fe atom/ions and the depth of modification for MNPs. It was found that the Fe3O4-HA MNPs contain the smallest, whereas the Fe3O4-APTES MNPs contain the largest amount of Fe2+ ions. Bioluminescent cellular and enzymatic assays were applied to monitor the toxicity and anti-(pro-)oxidant activity of MNPs. The contents of ROS were determined by a chemiluminescence luminol assay evaluating the correlations with toxicity/anti-(pro-)oxidant coefficients. Toxic effects of modified MNPs were found at higher concentrations (>10−2 g/L); they were related to ROS storage in bacterial suspensions. MNPs stimulated ROS production by the bacteria in a wide concentration range (10−15–1 g/L). Under the conditions of model oxidative stress and higher concentrations of MNPs (>10−4 g/L), the bacterial bioassay revealed prooxidant activity of all three MNP types, with corresponding decay of ROS content. Bioluminescence enzymatic assay did not show any sensitivity to MNPs, with negligible change in ROS content. The results clearly indicate that cell-membrane processes are responsible for the bioeffects and bacterial ROS generation, confirming the ferroptosis phenomenon based on iron-initiated cell-membrane lipid peroxidation.
Citations by journals
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1
2
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Pharmaceutics
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Pharmaceutics
2 publications, 28.57%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 28.57%
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Journal of Nanobiotechnology
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Journal of Nanobiotechnology
1 publication, 14.29%
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Chemical and Biological Technologies in Agriculture
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Chemical and Biological Technologies in Agriculture
1 publication, 14.29%
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1
2
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 57.14%
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Springer Nature
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Springer Nature
2 publications, 28.57%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kicheeva A. G. et al. Functionalized Magnetite Nanoparticles: Characterization, Bioeffects, and Role of Reactive Oxygen Species in Unicellular and Enzymatic Systems // International Journal of Molecular Sciences. 2023. Vol. 24. No. 2. p. 1133.
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Kicheeva A. G., Kovel E. S., Bondarenko L. S., Kydralieva K. A., Pankratov D. A., Tropskaya N. S., Dzeranov A., Dzhardimalieva G. I., Zarrelli M., Kudryasheva N. Functionalized Magnetite Nanoparticles: Characterization, Bioeffects, and Role of Reactive Oxygen Species in Unicellular and Enzymatic Systems // International Journal of Molecular Sciences. 2023. Vol. 24. No. 2. p. 1133.
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TY - JOUR
DO - 10.3390/ijms24021133
UR - https://doi.org/10.3390%2Fijms24021133
TI - Functionalized Magnetite Nanoparticles: Characterization, Bioeffects, and Role of Reactive Oxygen Species in Unicellular and Enzymatic Systems
T2 - International Journal of Molecular Sciences
AU - Kicheeva, Arina G
AU - Kovel, Ekaterina S
AU - Bondarenko, Lyubov S
AU - Kydralieva, Kamila A
AU - Pankratov, D. A.
AU - Tropskaya, Nataliya S
AU - Dzeranov, Artur
AU - Dzhardimalieva, G I
AU - Zarrelli, Mauro
AU - Kudryasheva, N.
PY - 2023
DA - 2023/01/06 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1133
IS - 2
VL - 24
PMID - 36674650
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2023_Kicheeva,
author = {Arina G Kicheeva and Ekaterina S Kovel and Lyubov S Bondarenko and Kamila A Kydralieva and D. A. Pankratov and Nataliya S Tropskaya and Artur Dzeranov and G I Dzhardimalieva and Mauro Zarrelli and N. Kudryasheva},
title = {Functionalized Magnetite Nanoparticles: Characterization, Bioeffects, and Role of Reactive Oxygen Species in Unicellular and Enzymatic Systems},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fijms24021133},
number = {2},
pages = {1133},
doi = {10.3390/ijms24021133}
}
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Kicheeva, Arina G., et al. “Functionalized Magnetite Nanoparticles: Characterization, Bioeffects, and Role of Reactive Oxygen Species in Unicellular and Enzymatic Systems.” International Journal of Molecular Sciences, vol. 24, no. 2, Jan. 2023, p. 1133. https://doi.org/10.3390%2Fijms24021133.