Open Access
International Journal of Molecular Sciences, volume 24, issue 12, pages 10302
Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing
JIAO Wei-wei
2
,
Sinkov Viacheslav
1
,
Khromova Polina
1
,
Solovieva Natalia
3
,
Mushkin Alexander
3
,
Mokrousov I. V.
4, 5
,
Belopolskaya Olesya
6
,
Masharsky Aleksey
6
,
Vyazovaya Anna
4
,
Rychkova Lubov
1
,
Kolesnikova Lubov
1
,
Shen A Dong
2, 5
,
5
Henan International Joint Laboratory of Children’s Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital Zhengzhou Children’s Hospital, Zhengzhou 450012, China
|
Publication type: Journal Article
Publication date: 2023-06-18
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
This study aimed to determine phenotypic and genotypic drug resistance patterns of Mycobacterium tuberculosis strains from children with tuberculosis (TB) in China and Russia, two high-burden countries for multi/extensively-drug resistant (MDR/XDR) TB. Whole-genome sequencing data of M. tuberculosis isolates from China (n = 137) and Russia (n = 60) were analyzed for phylogenetic markers and drug-resistance mutations, followed by comparison with phenotypic susceptibility data. The Beijing genotype was detected in 126 Chinese and 50 Russian isolates. The Euro-American lineage was detected in 10 Russian and 11 Chinese isolates. In the Russian collection, the Beijing genotype and Beijing B0/W148-cluster were dominated by MDR strains (68% and 94%, respectively). Ninety percent of B0/W148 strains were phenotypically pre-XDR. In the Chinese collection, neither of the Beijing sublineages was associated with MDR/pre-XDR status. MDR was mostly caused by low fitness cost mutations (rpoB S450L, katG S315T, rpsL K43R). Chinese rifampicin-resistant strains demonstrated a higher diversity of resistance mutations than Russian isolates (p = 0.003). The rifampicin and isoniazid resistance compensatory mutations were detected in some MDR strains, but they were not widespread. The molecular mechanisms of M. tuberculosis adaptation to anti-TB treatment are not unique to the pediatric strains, but they reflect the general situation with TB in Russia and China.
Citations by journals
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1
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European Journal of Clinical Microbiology and Infectious Diseases
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European Journal of Clinical Microbiology and Infectious Diseases
1 publication, 100%
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1
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Citations by publishers
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1
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Springer Nature
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Springer Nature
1 publication, 100%
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1
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Zhdanova S. et al. Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing // International Journal of Molecular Sciences. 2023. Vol. 24. No. 12. p. 10302.
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Zhdanova S., JIAO W., Sinkov V., Khromova P., Solovieva N., Mushkin A., Mokrousov I. V., Belopolskaya O., Masharsky A., Vyazovaya A., Rychkova L., Kolesnikova L., Zhuravlev V. V., Shen A. D., Ogarkov O. Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing // International Journal of Molecular Sciences. 2023. Vol. 24. No. 12. p. 10302.
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TY - JOUR
DO - 10.3390/ijms241210302
UR - https://doi.org/10.3390%2Fijms241210302
TI - Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing
T2 - International Journal of Molecular Sciences
AU - Zhdanova, Svetlana
AU - JIAO, Wei-wei
AU - Sinkov, Viacheslav
AU - Khromova, Polina
AU - Solovieva, Natalia
AU - Mushkin, Alexander
AU - Mokrousov, I. V.
AU - Belopolskaya, Olesya
AU - Masharsky, Aleksey
AU - Vyazovaya, Anna
AU - Rychkova, Lubov
AU - Kolesnikova, Lubov
AU - Zhuravlev, Viacheslav V.
AU - Shen, A Dong
AU - Ogarkov, Oleg
PY - 2023
DA - 2023/06/18 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 10302
IS - 12
VL - 24
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2023_Zhdanova,
author = {Svetlana Zhdanova and Wei-wei JIAO and Viacheslav Sinkov and Polina Khromova and Natalia Solovieva and Alexander Mushkin and I. V. Mokrousov and Olesya Belopolskaya and Aleksey Masharsky and Anna Vyazovaya and Lubov Rychkova and Lubov Kolesnikova and Viacheslav V. Zhuravlev and A Dong Shen and Oleg Ogarkov},
title = {Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fijms241210302},
number = {12},
pages = {10302},
doi = {10.3390/ijms241210302}
}
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MLA
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Zhdanova, Svetlana, et al. “Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing.” International Journal of Molecular Sciences, vol. 24, no. 12, Jun. 2023, p. 10302. https://doi.org/10.3390%2Fijms241210302.