Open Access
International Journal of Molecular Sciences, volume 24, issue 16, pages 12689
Neuroinflammatory Dysfunction of the Blood–Brain Barrier and Basement Membrane Dysplasia Play a Role in the Development of Drug-Resistant Epilepsy
Zabrodskaya Yulia
1
,
Paramonova Natalia
2, 3
,
Litovchenko Anastasia V
2
,
Bazhanova Elena D.
2, 4
,
Gerasimov A. P.
1
,
Sitovskaya D. A.
1
,
Nezdorovina Victoria
1
,
Kravtsova Svetlana
1
,
Malyshev Stanislav
1
,
Skiteva Ekaterina
1, 5
,
Samochernykh Konstantin
1
3
State Research Testing Institute of Military Medicine of the Ministry of Defense of the Russian Federation, 195043 St. Petersburg, Russia
|
Publication type: Journal Article
Publication date: 2023-08-11
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Drug-resistance epilepsy (DRE) is a key problem in neurology. It is possible that damage to the blood–brain barrier (BBB) may affect resistance in DRE. The aim of this work was to assess the damage and dysfunction in the BBB in the area of epileptic foci in patients with DRE under conditions of neuroinflammation. The changes to the BBB in temporal lobe epilepsy (by immunohistochemistry and transmission electron microscopy), levels of neuroinflammatory proteins, and cytokine levels in the blood (by multiplex analysis) were studied. Increased levels of vascular endothelial growth factor (VEGF) and growth-regulated protein (GRO), and decreased levels of epidermal growth factor (EGF) in plasma, combined with overexpression of the VEGF-A receptor by endotheliocytes were detected. Malformation-like growths of the basement membrane of the capillaries of the brain complicate the delivery of antiepileptic drugs (AEDs). Dysplasia of the basement membrane is the result of inadequate reparative processes in chronic inflammation. In conclusion, it should be noted that damage to the microcirculatory network of the brain should be considered one of the leading factors contributing to DRE.
Citations by journals
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International Immunopharmacology
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International Immunopharmacology
1 publication, 100%
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1
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Citations by publishers
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1
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Elsevier
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Elsevier
1 publication, 100%
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1
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Zabrodskaya Y. et al. Neuroinflammatory Dysfunction of the Blood–Brain Barrier and Basement Membrane Dysplasia Play a Role in the Development of Drug-Resistant Epilepsy // International Journal of Molecular Sciences. 2023. Vol. 24. No. 16. p. 12689.
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Zabrodskaya Y., Paramonova N., Litovchenko A. V., Bazhanova E. D., Gerasimov A. P., Sitovskaya D. A., Nezdorovina V., Kravtsova S., Malyshev S., Skiteva E., Samochernykh K. Neuroinflammatory Dysfunction of the Blood–Brain Barrier and Basement Membrane Dysplasia Play a Role in the Development of Drug-Resistant Epilepsy // International Journal of Molecular Sciences. 2023. Vol. 24. No. 16. p. 12689.
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TY - JOUR
DO - 10.3390/ijms241612689
UR - https://doi.org/10.3390%2Fijms241612689
TI - Neuroinflammatory Dysfunction of the Blood–Brain Barrier and Basement Membrane Dysplasia Play a Role in the Development of Drug-Resistant Epilepsy
T2 - International Journal of Molecular Sciences
AU - Zabrodskaya, Yulia
AU - Paramonova, Natalia
AU - Litovchenko, Anastasia V
AU - Bazhanova, Elena D.
AU - Gerasimov, A. P.
AU - Sitovskaya, D. A.
AU - Nezdorovina, Victoria
AU - Kravtsova, Svetlana
AU - Malyshev, Stanislav
AU - Skiteva, Ekaterina
AU - Samochernykh, Konstantin
PY - 2023
DA - 2023/08/11 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 12689
IS - 16
VL - 24
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2023_Zabrodskaya,
author = {Yulia Zabrodskaya and Natalia Paramonova and Anastasia V Litovchenko and Elena D. Bazhanova and A. P. Gerasimov and D. A. Sitovskaya and Victoria Nezdorovina and Svetlana Kravtsova and Stanislav Malyshev and Ekaterina Skiteva and Konstantin Samochernykh},
title = {Neuroinflammatory Dysfunction of the Blood–Brain Barrier and Basement Membrane Dysplasia Play a Role in the Development of Drug-Resistant Epilepsy},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {aug},
url = {https://doi.org/10.3390%2Fijms241612689},
number = {16},
pages = {12689},
doi = {10.3390/ijms241612689}
}
Cite this
MLA
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Zabrodskaya, Yulia, et al. “Neuroinflammatory Dysfunction of the Blood–Brain Barrier and Basement Membrane Dysplasia Play a Role in the Development of Drug-Resistant Epilepsy.” International Journal of Molecular Sciences, vol. 24, no. 16, Aug. 2023, p. 12689. https://doi.org/10.3390%2Fijms241612689.