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International Journal of Molecular Sciences, volume 24, issue 18, pages 14206

Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota

Zabolotneva Anastasia A. 1, 2
, 
Gaponov Andrei M. 3
, 
Roumiantsev Sergey A. 1, 2
, 
Vasiliev Ilya Yu 4
, 
Grigoryeva Tatiana V 4
, 
Kit Oleg I 5
, 
Zlatnik Elena Yu 5
, 
Maksimov Aleksey Yu. 5
, 
Goncharova Anna S 5
, 
Novikova Inna A 5
, 
Appolonova Svetlana A 6
, 
Markin Pavel A 6
, 
Shestopalov Aleksandr V 1, 2, 7
1
 
2
 
3
 
Center for Digital and Translational Biomedicine «Center for Molecular Health», 32 Nakhimovskiy prospekt, Moscow 117218, Russia | 
4
 
5
 
National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia | 
6
 
7
 
Publication type: Journal Article
Publication date: 2023-09-18
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract

Alkylresorcinols (ARs) are polyphenolic compounds with a wide spectrum of biological activities and are potentially involved in the regulation of host metabolism. The present study aims to establish whether ARs can be produced by the human gut microbiota and to evaluate alterations in content in stool samples as well as metabolic activity of the gut microbiota of C57BL, db/db, and LDLR (−/−) mice according to diet specifications and olivetol (5-n-pentylresorcinol) supplementation to estimate the regulatory potential of ARs. Gas chromatography with mass spectrometric detection was used to quantitatively analyse AR levels in mouse stool samples; faecal microbiota transplantation (FMT) from human donors to germ-free mice was performed to determine whether the intestinal microbiota could produce AR molecules; metagenome sequencing analysis of the mouse gut microbiota followed by reconstruction of its metabolic activity was performed to investigate olivetol’s regulatory potential. A significant increase in the amounts of individual members of AR homologues in stool samples was revealed 14 days after FMT. Supplementation of 5-n-Pentylresorcinol to a regular diet influences the amounts of several ARs in the stool of C57BL/6 and LDLR (−/−) but not db/db mice, and caused a significant change in the predicted metabolic activity of the intestinal microbiota of C57BL/6 and LDLR (−/−) but not db/db mice. For the first time, we have shown that several ARs can be produced by the intestinal microbiota. Taking into account the dependence of AR levels in the gut on olivetol supplementation and microbiota metabolic activity, AR can be assumed to be potential quorum-sensing molecules, which also influence gut microbiota composition and host metabolism.

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Zabolotneva A. A. et al. Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota // International Journal of Molecular Sciences. 2023. Vol. 24. No. 18. p. 14206.
GOST all authors (up to 50) Copy
Zabolotneva A. A., Gaponov A. M., Roumiantsev S. A., Vasiliev I. Yu., Grigoryeva T. V., Kit O. I., Zlatnik E. Yu., Maksimov A. Y., Goncharova A. S., Novikova I. A., Appolonova S. A., Markin P. A., Shestopalov A. V. Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota // International Journal of Molecular Sciences. 2023. Vol. 24. No. 18. p. 14206.
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TY - JOUR
DO - 10.3390/ijms241814206
UR - https://doi.org/10.3390%2Fijms241814206
TI - Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota
T2 - International Journal of Molecular Sciences
AU - Zabolotneva, Anastasia A.
AU - Gaponov, Andrei M.
AU - Roumiantsev, Sergey A.
AU - Vasiliev, Ilya Yu
AU - Grigoryeva, Tatiana V
AU - Kit, Oleg I
AU - Zlatnik, Elena Yu
AU - Maksimov, Aleksey Yu.
AU - Goncharova, Anna S
AU - Novikova, Inna A
AU - Appolonova, Svetlana A
AU - Markin, Pavel A
AU - Shestopalov, Aleksandr V
PY - 2023
DA - 2023/09/18 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 14206
IS - 18
VL - 24
SN - 1661-6596
SN - 1422-0067
ER -
BibTex |
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@article{2023_Zabolotneva,
author = {Anastasia A. Zabolotneva and Andrei M. Gaponov and Sergey A. Roumiantsev and Ilya Yu Vasiliev and Tatiana V Grigoryeva and Oleg I Kit and Elena Yu Zlatnik and Aleksey Yu. Maksimov and Anna S Goncharova and Inna A Novikova and Svetlana A Appolonova and Pavel A Markin and Aleksandr V Shestopalov},
title = {Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota},
journal = {International Journal of Molecular Sciences},
year = {2023},
volume = {24},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {sep},
url = {https://doi.org/10.3390%2Fijms241814206},
number = {18},
pages = {14206},
doi = {10.3390/ijms241814206}
}
MLA
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MLA Copy
Zabolotneva, Anastasia A., et al. “Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota.” International Journal of Molecular Sciences, vol. 24, no. 18, Sep. 2023, p. 14206. https://doi.org/10.3390%2Fijms241814206.
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