Open Access
Life, volume 11, issue 5, pages 449
Plantar Stimulations during 3-Day Hindlimb Unloading Prevent Loss of Neural Progenitors and Maintain ERK1/2 Activity in the Rat Hippocampus
Publication type: Journal Article
Publication date: 2021-05-17
General Biochemistry, Genetics and Molecular Biology
Ecology, Evolution, Behavior and Systematics
Paleontology
Space and Planetary Science
Abstract
Adult neurogenesis is a flexible process that depends on the environment and correlates with cognitive functions. Cognitive functions are impaired by various factors including space flight conditions and reduced physical activity. Physically active life significantly improves both cognition and the hippocampal neurogenesis. Here, we analyzed how 3-day simulated microgravity caused by hindlimb unloading (HU) or dynamic foot stimulation (DFS) during HU can affect the hippocampal neurogenesis. Adult Wistar rats were recruited in the experiments. The results demonstrated a decrease in the number of doublecortine (DCX) positive neural progenitors, but proliferation in the subgranular zone of the dentate gyrus was not changed after 3-day HU. Analysis of the effects of DFS showed restoration of neural progenitor population in the subgranular zone of the dentate gyrus. Additionally, we analyzed activity of the cRaf/ERK1/2 pathway, which is one of the major players in the regulation of neuronal differentiation. The results demonstrated inhibition of cRaf/ERK1/2 signaling in the hippocampus of HU rats. In DFS rats, no changes in the activity of cRaf/ERK1/2 were observed. Thus, we demonstrated that the process of neurogenesis fading during HU begins with inhibition of the formation of immature neurons and associated ERK1/2 signaling activity, while DFS prevents the development of mentioned alterations.
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Journal of Evolutionary Biochemistry and Physiology
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Berezovskaya A. S. et al. Plantar Stimulations during 3-Day Hindlimb Unloading Prevent Loss of Neural Progenitors and Maintain ERK1/2 Activity in the Rat Hippocampus // Life. 2021. Vol. 11. No. 5. p. 449.
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Berezovskaya A. S., Tyganov S. A., Nikolaeva S. D., Naumova A. A., Shenkman B. S., Glazova M. V. Plantar Stimulations during 3-Day Hindlimb Unloading Prevent Loss of Neural Progenitors and Maintain ERK1/2 Activity in the Rat Hippocampus // Life. 2021. Vol. 11. No. 5. p. 449.
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TY - JOUR
DO - 10.3390/life11050449
UR - https://doi.org/10.3390%2Flife11050449
TI - Plantar Stimulations during 3-Day Hindlimb Unloading Prevent Loss of Neural Progenitors and Maintain ERK1/2 Activity in the Rat Hippocampus
T2 - Life
AU - Berezovskaya, Anna S
AU - Tyganov, Sergey A
AU - Nikolaeva, Svetlana D
AU - Naumova, Alexandra A
AU - Shenkman, Boris S.
AU - Glazova, M. V.
PY - 2021
DA - 2021/05/17 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 449
IS - 5
VL - 11
SN - 2075-1729
ER -
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@article{2021_Berezovskaya,
author = {Anna S Berezovskaya and Sergey A Tyganov and Svetlana D Nikolaeva and Alexandra A Naumova and Boris S. Shenkman and M. V. Glazova},
title = {Plantar Stimulations during 3-Day Hindlimb Unloading Prevent Loss of Neural Progenitors and Maintain ERK1/2 Activity in the Rat Hippocampus},
journal = {Life},
year = {2021},
volume = {11},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Flife11050449},
number = {5},
pages = {449},
doi = {10.3390/life11050449}
}
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Berezovskaya, Anna S., et al. “Plantar Stimulations during 3-Day Hindlimb Unloading Prevent Loss of Neural Progenitors and Maintain ERK1/2 Activity in the Rat Hippocampus.” Life, vol. 11, no. 5, May. 2021, p. 449. https://doi.org/10.3390%2Flife11050449.
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