Open Access
Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus
Oh Seok Kwon
1
,
Donghwa Kim
1
,
Chang Kwon Kim
1
,
Jeongyoon Sun
2
,
Chung J. Sim
3
,
Dong-Chan Oh
1
,
Sang Kook Lee
1
,
Ki-Bong Oh
2
,
Jongheon Shin
1
Publication type: Journal Article
Publication date: 2020-05-13
PubMed ID:
32414015
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
Twelve new sesterterpenes along with eight known sesterterpenes were isolated from the marine sponge Hyrtios erectus collected off the coast of Chuuk Island, the Federated State of Micronesia. Based upon a combination of spectroscopic and computational analyses, these compounds were determined to be eight glycine-bearing scalaranes (1–8), a 3-keto scalarane (9), two oxidized-furan-bearing scalaranes (10 and 11), and a salmahyrtisane (12). Several of these compounds exhibited weak antiproliferation against diverse cancer cell lines as well as moderate anti-angiogenesis activities. The antiproliferative activity of new compound 4 was found to be associated with G0/G1 arrest in the cell cycle.
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18
Total citations:
18
Citations from 2024:
7
(38.89%)
Cite this
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RIS |
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MLA
Cite this
GOST
Copy
Kwon O. S. et al. Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus // Marine Drugs. 2020. Vol. 18. No. 5. p. 253.
GOST all authors (up to 50)
Copy
Kwon O. S., Kim D., Kim C. K., Sun J., Sim C. J., Oh D., Lee S. K., Oh K., Shin J. Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus // Marine Drugs. 2020. Vol. 18. No. 5. p. 253.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/md18050253
UR - https://doi.org/10.3390/md18050253
TI - Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus
T2 - Marine Drugs
AU - Kwon, Oh Seok
AU - Kim, Donghwa
AU - Kim, Chang Kwon
AU - Sun, Jeongyoon
AU - Sim, Chung J.
AU - Oh, Dong-Chan
AU - Lee, Sang Kook
AU - Oh, Ki-Bong
AU - Shin, Jongheon
PY - 2020
DA - 2020/05/13
PB - MDPI
SP - 253
IS - 5
VL - 18
PMID - 32414015
SN - 1660-3397
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2020_Kwon,
author = {Oh Seok Kwon and Donghwa Kim and Chang Kwon Kim and Jeongyoon Sun and Chung J. Sim and Dong-Chan Oh and Sang Kook Lee and Ki-Bong Oh and Jongheon Shin},
title = {Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus},
journal = {Marine Drugs},
year = {2020},
volume = {18},
publisher = {MDPI},
month = {may},
url = {https://doi.org/10.3390/md18050253},
number = {5},
pages = {253},
doi = {10.3390/md18050253}
}
Cite this
MLA
Copy
Kwon, Oh Seok, et al. “Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus.” Marine Drugs, vol. 18, no. 5, May. 2020, p. 253. https://doi.org/10.3390/md18050253.