Open Access
Molecules, volume 25, issue 8, pages 1949
Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers
Demina Tatiana
1, 2
,
Drozdova Maria G
3
,
Sevrin Chantal
4
,
Compère Philippe
4, 5
,
Markvicheva Elena
3
,
Grandfils Christian
4
Publication type: Journal Article
Publication date: 2020-04-22
PubMed ID:
32331458
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Self-stabilizing biodegradable microcarriers were produced via an oil/water solvent evaporation technique using amphiphilic chitosan-g-polyester copolymers as a core material in oil phase without the addition of any emulsifier in aqueous phase. The total yield of the copolymer-based microparticles reached up to 79 wt. %, which is comparable to a yield achievable using traditional emulsifiers. The kinetics of microparticle self-stabilization, monitored during their process, were correlated to the migration of hydrophilic copolymer’s moieties to the oil/water interface. With a favorable surface/volume ratio and the presence of bioadhesive natural fragments anchored to their surface, the performance of these novel microcarriers has been highlighted by evaluating cell morphology and proliferation within a week of cell cultivation in vitro.
Citations by journals
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1
2
3
4
5
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Polymers
|
Polymers
5 publications, 55.56%
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Journal of Materials Research
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Journal of Materials Research
1 publication, 11.11%
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Small
|
Small
1 publication, 11.11%
|
|
Polymer Science - Series C
|
Polymer Science - Series C
1 publication, 11.11%
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Journal of Macromolecular Science - Pure and Applied Chemistry
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Journal of Macromolecular Science - Pure and Applied Chemistry
1 publication, 11.11%
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1
2
3
4
5
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Citations by publishers
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1
2
3
4
5
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
5 publications, 55.56%
|
|
Cambridge University Press
|
Cambridge University Press
1 publication, 11.11%
|
|
Wiley
|
Wiley
1 publication, 11.11%
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Pleiades Publishing
|
Pleiades Publishing
1 publication, 11.11%
|
|
Taylor & Francis
|
Taylor & Francis
1 publication, 11.11%
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1
2
3
4
5
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Demina T. et al. Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers // Molecules. 2020. Vol. 25. No. 8. p. 1949.
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Demina T., Drozdova M. G., Sevrin C., Compère P., Akopova T. A., Markvicheva E., Grandfils C. Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers // Molecules. 2020. Vol. 25. No. 8. p. 1949.
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TY - JOUR
DO - 10.3390/molecules25081949
UR - https://doi.org/10.3390%2Fmolecules25081949
TI - Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers
T2 - Molecules
AU - Drozdova, Maria G
AU - Sevrin, Chantal
AU - Akopova, Tatiana A
AU - Markvicheva, Elena
AU - Grandfils, Christian
AU - Demina, Tatiana
AU - Compère, Philippe
PY - 2020
DA - 2020/04/22 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1949
IS - 8
VL - 25
PMID - 32331458
SN - 1420-3049
ER -
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@article{2020_Demina,
author = {Maria G Drozdova and Chantal Sevrin and Tatiana A Akopova and Elena Markvicheva and Christian Grandfils and Tatiana Demina and Philippe Compère},
title = {Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers},
journal = {Molecules},
year = {2020},
volume = {25},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {apr},
url = {https://doi.org/10.3390%2Fmolecules25081949},
number = {8},
pages = {1949},
doi = {10.3390/molecules25081949}
}
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MLA
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Demina, Tatiana, et al. “Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers.” Molecules, vol. 25, no. 8, Apr. 2020, p. 1949. https://doi.org/10.3390%2Fmolecules25081949.