Open Access
Molecules, volume 25, issue 22, pages 5437
Assembling the Puzzle of Taxifolin Polymorphism
Terekhov Roman
1
,
Tyukavkina Nonna A.
1
,
Ilyasov Igor R
1
,
Zhevlakova Anastasiya K
1
,
Dzuban Alexander V
2
,
Bogdanov Anatoliy G
3
,
Davidovich Georgiy N
3
,
Shylov Gennadii V
4
,
Utenishev Andrey N.
1, 4
,
Kovalev D. P.
5
,
Fenin Anatoliy A
6
,
Kabluchko Tatyana G
7
3
7
Department of Technology, Ametis JSC, Naberezhnaya st. 68, 675000 Blagoveshchensk, Russia
|
Publication type: Journal Article
Publication date: 2020-11-20
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
A large amount of the current literature dedicated to solid states of active pharmaceutical ingredients (APIs) pays special attention to polymorphism of flavonoids. Taxifolin (also known as dihydroquercetin) is an example of a typical flavonoid. Some new forms of taxifolin have been reported previously, however it is still unclear whether they represent polymorphic modifications. In this paper, we tried to answer the question about the taxifolin polymorphism. Taxifolin microtubes and taxifolin microspheres were synthesized from raw taxifolin API using several methods of crystal engineering. All forms were described with the help of spectral methods, scanning electron microscopy (SEM), X-ray powder diffraction (XRPD), and thermal analysis (TA). SEM reveals that the morphology of the solid phase is very specific for each sample. Although XRPD patterns of raw taxifolin and microtubes look similar, their TA profiles differ significantly. At the same time, raw taxifolin and microspheres have nearly identical thermograms, while XRPD shows that the former is a crystalline and the latter is an amorphous substance. Only the use of complex analyses allowed us to put the puzzle together and to confirm the polymorphism of taxifolin. This article demonstrates that taxifolin microtubes are a pseudopolymorphic modification of raw taxifolin.
Citations by journals
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Citations by publishers
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6
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Multidisciplinary Digital Publishing Institute (MDPI)
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6 publications, 42.86%
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Springer Nature
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4 publications, 28.57%
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Pontificia Universidade Catolica de Campinas, 1, 7.14%
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1 publication, 7.14%
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Beilstein-Institut
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1 publication, 7.14%
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Center of Pharmaceutical Analytics Ltd
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Center of Pharmaceutical Analytics Ltd
1 publication, 7.14%
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1
2
3
4
5
6
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Terekhov R. et al. Assembling the Puzzle of Taxifolin Polymorphism // Molecules. 2020. Vol. 25. No. 22. p. 5437.
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Terekhov R., Selivanova I. A., Tyukavkina N. A., Ilyasov I. R., Zhevlakova A. K., Dzuban A. V., Bogdanov A. G., Davidovich G. N., Shylov G. V., Utenishev A. N., Kovalev D. P., Fenin A. A., Kabluchko T. G. Assembling the Puzzle of Taxifolin Polymorphism // Molecules. 2020. Vol. 25. No. 22. p. 5437.
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TY - JOUR
DO - 10.3390/molecules25225437
UR - https://doi.org/10.3390%2Fmolecules25225437
TI - Assembling the Puzzle of Taxifolin Polymorphism
T2 - Molecules
AU - Selivanova, Irina A
AU - Tyukavkina, Nonna A.
AU - Ilyasov, Igor R
AU - Zhevlakova, Anastasiya K
AU - Dzuban, Alexander V
AU - Bogdanov, Anatoliy G
AU - Davidovich, Georgiy N
AU - Shylov, Gennadii V
AU - Utenishev, Andrey N.
AU - Fenin, Anatoliy A
AU - Kabluchko, Tatyana G
AU - Terekhov, Roman
AU - Kovalev, D. P.
PY - 2020
DA - 2020/11/20 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 5437
IS - 22
VL - 25
SN - 1420-3049
ER -
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@article{2020_Terekhov,
author = {Irina A Selivanova and Nonna A. Tyukavkina and Igor R Ilyasov and Anastasiya K Zhevlakova and Alexander V Dzuban and Anatoliy G Bogdanov and Georgiy N Davidovich and Gennadii V Shylov and Andrey N. Utenishev and Anatoliy A Fenin and Tatyana G Kabluchko and Roman Terekhov and D. P. Kovalev},
title = {Assembling the Puzzle of Taxifolin Polymorphism},
journal = {Molecules},
year = {2020},
volume = {25},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2Fmolecules25225437},
number = {22},
pages = {5437},
doi = {10.3390/molecules25225437}
}
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Terekhov, Roman, et al. “Assembling the Puzzle of Taxifolin Polymorphism.” Molecules, vol. 25, no. 22, Nov. 2020, p. 5437. https://doi.org/10.3390%2Fmolecules25225437.