Open Access
Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G
Leander Geske
1
,
Ulrich Kauhl
1
,
Mohamed Saeed
2
,
Anja Schüffler
3, 4
,
Eckhard Thines
3, 4
,
Thomas Efferth
2
,
Till Opatz
1
3
Institut für Biotechnologie und Wirkstoff-Forschung gGmbH, Hanns-Dieter-Hüsch-Weg 17, 55128 Mainz, Germany
|
Publication type: Journal Article
Publication date: 2021-05-27
PubMed ID:
34072126
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regioselective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further structural variation.
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4
Total citations:
4
Citations from 2024:
1
(25%)
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GOST
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Geske L. et al. Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G // Molecules. 2021. Vol. 26. No. 11. p. 3224.
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Geske L., Kauhl U., Saeed M., Schüffler A., Thines E., Efferth T., Opatz T. Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G // Molecules. 2021. Vol. 26. No. 11. p. 3224.
Cite this
RIS
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TY - JOUR
DO - 10.3390/molecules26113224
UR - https://doi.org/10.3390/molecules26113224
TI - Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G
T2 - Molecules
AU - Geske, Leander
AU - Kauhl, Ulrich
AU - Saeed, Mohamed
AU - Schüffler, Anja
AU - Thines, Eckhard
AU - Efferth, Thomas
AU - Opatz, Till
PY - 2021
DA - 2021/05/27
PB - MDPI
SP - 3224
IS - 11
VL - 26
PMID - 34072126
SN - 1420-3049
ER -
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BibTex (up to 50 authors)
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@article{2021_Geske,
author = {Leander Geske and Ulrich Kauhl and Mohamed Saeed and Anja Schüffler and Eckhard Thines and Thomas Efferth and Till Opatz},
title = {Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {MDPI},
month = {may},
url = {https://doi.org/10.3390/molecules26113224},
number = {11},
pages = {3224},
doi = {10.3390/molecules26113224}
}
Cite this
MLA
Copy
Geske, Leander, et al. “Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G.” Molecules, vol. 26, no. 11, May. 2021, p. 3224. https://doi.org/10.3390/molecules26113224.