Open Access
Molecules, volume 26, issue 22, pages 6786
Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability
Vasileva Leysan
1
,
Kashapov Ruslan
1
,
Kuznetsova Darya
1
,
Tyryshkina Anna
1
,
Vasilieva Elmira
1
,
Petrov Konstantin
1
,
Zakharova Lucia
1
,
Sinyashin Oleg
1
Publication type: Journal Article
Publication date: 2021-11-10
PubMed ID:
34833877
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
This review focuses on key topics in the field of drug delivery related to the design of nanocarriers answering the biomedicine criteria, including biocompatibility, biodegradability, low toxicity, and the ability to overcome biological barriers. For these reasons, much attention is paid to the amphiphile-based carriers composed of natural building blocks, lipids, and their structural analogues and synthetic surfactants that are capable of self-assembly with the formation of a variety of supramolecular aggregates. The latter are dynamic structures that can be used as nanocontainers for hydrophobic drugs to increase their solubility and bioavailability. In this section, biodegradable cationic surfactants bearing cleavable fragments are discussed, with ester- and carbamate-containing analogs, as well as amino acid derivatives received special attention. Drug delivery through the biological barriers is a challenging task, which is highlighted by the example of transdermal method of drug administration. In this paper, nonionic surfactants are primarily discussed, including their application for the fabrication of nanocarriers, their surfactant-skin interactions, the mechanisms of modulating their permeability, and the factors controlling drug encapsulation, release, and targeted delivery. Different types of nanocarriers are covered, including niosomes, transfersomes, invasomes and chitosomes, with their morphological specificity, beneficial characteristics and limitations discussed.
Citations by journals
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4
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Russian Chemical Bulletin
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Russian Chemical Bulletin
4 publications, 12.9%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
4 publications, 12.9%
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Pharmaceutics
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Pharmaceutics
3 publications, 9.68%
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Colloids and Surfaces A: Physicochemical and Engineering Aspects
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Colloids and Surfaces A: Physicochemical and Engineering Aspects
3 publications, 9.68%
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Molecules
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Molecules
2 publications, 6.45%
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Russian Journal of General Chemistry
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Russian Journal of General Chemistry
2 publications, 6.45%
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ACS Omega
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ACS Omega
1 publication, 3.23%
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Langmuir
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Langmuir
1 publication, 3.23%
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Journal of Molecular Liquids
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Journal of Molecular Liquids
1 publication, 3.23%
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Biochimica et Biophysica Acta - General Subjects
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Biochimica et Biophysica Acta - General Subjects
1 publication, 3.23%
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Colloids and Surfaces B: Biointerfaces
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Colloids and Surfaces B: Biointerfaces
1 publication, 3.23%
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Food Bioscience
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Food Bioscience
1 publication, 3.23%
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Colloid Journal
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Colloid Journal
1 publication, 3.23%
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Current Medicinal Chemistry
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Current Medicinal Chemistry
1 publication, 3.23%
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Current Pharmaceutical Biotechnology
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Current Pharmaceutical Biotechnology
1 publication, 3.23%
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Materials
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Materials
1 publication, 3.23%
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BIO Web of Conferences
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BIO Web of Conferences
1 publication, 3.23%
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International Journal of Pharmaceutics
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International Journal of Pharmaceutics
1 publication, 3.23%
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1
2
3
4
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Citations by publishers
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2
4
6
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10
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
10 publications, 32.26%
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Elsevier
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Elsevier
8 publications, 25.81%
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Springer Nature
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Springer Nature
4 publications, 12.9%
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Pleiades Publishing
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Pleiades Publishing
3 publications, 9.68%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
2 publications, 6.45%
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Bentham Science
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Bentham Science
2 publications, 6.45%
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EDP Sciences
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EDP Sciences
1 publication, 3.23%
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2
4
6
8
10
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Gaynanova G. et al. Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability // Molecules. 2021. Vol. 26. No. 22. p. 6786.
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Gaynanova G., Vasileva L., Kashapov R., Kuznetsova D., Kushnazarova R., Tyryshkina A., Vasilieva E., Petrov K., Zakharova L., Sinyashin O. Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability // Molecules. 2021. Vol. 26. No. 22. p. 6786.
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TY - JOUR
DO - 10.3390/molecules26226786
UR - https://doi.org/10.3390%2Fmolecules26226786
TI - Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability
T2 - Molecules
AU - Gaynanova, Gulnara
AU - Vasileva, Leysan
AU - Kashapov, Ruslan
AU - Kuznetsova, Darya
AU - Kushnazarova, Rushana
AU - Tyryshkina, Anna
AU - Vasilieva, Elmira
AU - Petrov, Konstantin
AU - Zakharova, Lucia
AU - Sinyashin, Oleg
PY - 2021
DA - 2021/11/10 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 6786
IS - 22
VL - 26
PMID - 34833877
SN - 1420-3049
ER -
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@article{2021_Gaynanova,
author = {Gulnara Gaynanova and Leysan Vasileva and Ruslan Kashapov and Darya Kuznetsova and Rushana Kushnazarova and Anna Tyryshkina and Elmira Vasilieva and Konstantin Petrov and Lucia Zakharova and Oleg Sinyashin},
title = {Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2Fmolecules26226786},
number = {22},
pages = {6786},
doi = {10.3390/molecules26226786}
}
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Gaynanova, Gulnara, et al. “Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability.” Molecules, vol. 26, no. 22, Nov. 2021, p. 6786. https://doi.org/10.3390%2Fmolecules26226786.