Open Access
Molecules, volume 28, issue 3, pages 1165
Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells
Popov Anton L.
1
,
Ivanova Olga S.
2
,
Zhukov Ivan V.
3
,
Yurkovskaya Alexandra V.
3
,
Savelov Andrey A.
3
,
Ermakov Artem M.
1
,
Popova Nelli R.
1
,
Ivanov Konstantin L.
3
,
Ivanov Vladimir K.
1, 2
Publication type: Journal Article
Publication date: 2023-01-24
PubMed ID:
36770832
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Recently, human mesenchymal stem cells (hMSc) have attracted a great deal of attention as potential therapeutic agents in the treatment of socially significant diseases. Despite substantial advances in stem-cell therapy, the biological mechanisms of hMSc action after transplantation remain unclear. The use of magnetic resonance imaging (MRI) as a non-invasive method for tracking stem cells in the body is very important for analysing their distribution in tissues and organs, as well as for ensuring control of their lifetime after injection. Herein, detailed experimental data are reported on the biocompatibility towards hMSc of heavily gadolinium-doped cerium oxide nanoparticles (Ce0.8Gd0.2O2−x) synthesised using two synthetic protocols. The relaxivity of the nanoparticles was measured in a magnetic field range from 1 mT to 16.4 T. The relaxivity values (r1 = 11 ± 1.2 mM−1 s−1 and r1 = 7 ± 1.2 mM−1 s−1 in magnetic fields typical of 1.5 and 3 T MRI scanners, respectively) are considerably higher than those of the commercial Omniscan MRI contrast agent. The low toxicity of gadolinium-doped ceria nanoparticles to hMSc enables their use as an effective theranostic tool with improved MRI-contrasting properties.
Citations by journals
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1
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Nanomaterials
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Nanomaterials
1 publication, 25%
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Cells
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Cells
1 publication, 25%
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Journal of Rare Earths
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Journal of Rare Earths
1 publication, 25%
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Physics of Atomic Nuclei
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Physics of Atomic Nuclei
1 publication, 25%
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1
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 50%
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Chinese Society of Rare Earths
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Chinese Society of Rare Earths
1 publication, 25%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 25%
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1
2
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Popov A. L. et al. Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells // Molecules. 2023. Vol. 28. No. 3. p. 1165.
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Popov A. L., Savintseva I. V., Kozlova T. O., Ivanova O. S., Zhukov I. V., Baranchikov A. E., Yurkovskaya A. V., Savelov A. A., Ermakov A. M., Popova N. R., Ivanov K. L., Ivanov V. K. Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells // Molecules. 2023. Vol. 28. No. 3. p. 1165.
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TY - JOUR
DO - 10.3390/molecules28031165
UR - https://doi.org/10.3390%2Fmolecules28031165
TI - Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells
T2 - Molecules
AU - Popov, Anton L.
AU - Savintseva, Irina V.
AU - Kozlova, Taisiya O.
AU - Ivanova, Olga S.
AU - Zhukov, Ivan V.
AU - Baranchikov, Alexander E
AU - Yurkovskaya, Alexandra V.
AU - Savelov, Andrey A.
AU - Ermakov, Artem M.
AU - Popova, Nelli R.
AU - Ivanov, Konstantin L.
AU - Ivanov, Vladimir K.
PY - 2023
DA - 2023/01/24 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1165
IS - 3
VL - 28
PMID - 36770832
SN - 1420-3049
ER -
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@article{2023_Popov,
author = {Anton L. Popov and Irina V. Savintseva and Taisiya O. Kozlova and Olga S. Ivanova and Ivan V. Zhukov and Alexander E Baranchikov and Alexandra V. Yurkovskaya and Andrey A. Savelov and Artem M. Ermakov and Nelli R. Popova and Konstantin L. Ivanov and Vladimir K. Ivanov},
title = {Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells},
journal = {Molecules},
year = {2023},
volume = {28},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fmolecules28031165},
number = {3},
pages = {1165},
doi = {10.3390/molecules28031165}
}
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MLA
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Popov, Anton L., et al. “Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells.” Molecules, vol. 28, no. 3, Jan. 2023, p. 1165. https://doi.org/10.3390%2Fmolecules28031165.