Open Access
Nutrients, volume 13, issue 11, pages 3811
Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus
Povydysh Maria N
1
,
Titova Maria V.
2
,
Ivanov Igor M
2
,
Klushin Andrey G
2
,
Kochkin Dmitry V.
2, 3
,
Galishev Boris A.
4
,
Popova Elena
2
,
Ivkin Dmitry Yu
1
,
Luzhanin Vladimir G
1
,
Nosov Alexander M.
2, 3
3
Publication type: Journal Article
Publication date: 2021-10-26
PubMed ID:
34836067
Food Science
Nutrition and Dietetics
Abstract
In the present study, we explored the therapeutic potential of bioreactor-grown cell cultures of the medicinal plant species Dioscorea deltoidea, Tribulus terrestris and Panax japonicus to treat carbohydrate metabolism disorders (CMDs) in laboratory rats. In the adrenaline model of hyperglycemia, aqueous suspensions of cell biomass pre-administered at a dose of 100 mg dry biomass/kg significantly reduced glucose level in animal blood 1–2.5 h (D. deltoidea and T. terrestris) or 1 h (P. japonicus) after adrenaline hydrochloride administration. In a streptozotocin-induced model of type 2 diabetes mellitus, the cell biomass of D. deltoidea and T. terrestris acted towards normalization of carbohydrate and lipid metabolism, as evidenced by a significant reduction of daily diuresis (by 39–57%), blood-glucose level (by 46–51%), blood content in urine (by 78–80%) and total cholesterol (25–36%) compared to animals without treatment. Bioactive secondary metabolites identified in the cell cultures and potentially responsible for their actions were deltoside, 25(S)-protodioscin and protodioscin in D. deltoidea; furostanol-type steroidal glycosides and quinic acid derivatives in T. terrestris; and ginsenosides and malonyl-ginsenosides in P. japonicus. These results evidenced for high potential of bioreactor-grown cell suspensions of these species for prevention and treatment of CMD, which requires further investigation.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Povydysh M. N. et al. Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus // Nutrients. 2021. Vol. 13. No. 11. p. 3811.
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Povydysh M. N., Titova M. V., Ivanov I. M., Klushin A. G., Kochkin D. V., Galishev B. A., Popova E., Ivkin D. Yu., Luzhanin V. G., Krasnova M. V., Demakova N. V., Nosov A. M. Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus // Nutrients. 2021. Vol. 13. No. 11. p. 3811.
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TY - JOUR
DO - 10.3390/nu13113811
UR - https://doi.org/10.3390%2Fnu13113811
TI - Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus
T2 - Nutrients
AU - Povydysh, Maria N
AU - Titova, Maria V.
AU - Ivanov, Igor M
AU - Klushin, Andrey G
AU - Kochkin, Dmitry V.
AU - Galishev, Boris A.
AU - Ivkin, Dmitry Yu
AU - Luzhanin, Vladimir G
AU - Nosov, Alexander M.
AU - Popova, Elena
AU - Krasnova, Marina V
AU - Demakova, Natalia V
PY - 2021
DA - 2021/10/26 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 3811
IS - 11
VL - 13
PMID - 34836067
SN - 2072-6643
ER -
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@article{2021_Povydysh,
author = {Maria N Povydysh and Maria V. Titova and Igor M Ivanov and Andrey G Klushin and Dmitry V. Kochkin and Boris A. Galishev and Dmitry Yu Ivkin and Vladimir G Luzhanin and Alexander M. Nosov and Elena Popova and Marina V Krasnova and Natalia V Demakova},
title = {Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus},
journal = {Nutrients},
year = {2021},
volume = {13},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {oct},
url = {https://doi.org/10.3390%2Fnu13113811},
number = {11},
pages = {3811},
doi = {10.3390/nu13113811}
}
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Povydysh, Maria N., et al. “Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus.” Nutrients, vol. 13, no. 11, Oct. 2021, p. 3811. https://doi.org/10.3390%2Fnu13113811.