Open Access
Pharmaceutics, volume 13, issue 2, pages 144
Protective Effect of Mitochondria-Targeted Antioxidants against Inflammatory Response to Lipopolysaccharide Challenge: A Review
Publication type: Journal Article
Publication date: 2021-01-22
PubMed ID:
33499252
Pharmaceutical Science
Abstract
Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is the most abundant proinflammatory agent. Considerable evidence indicates that LPS challenge inescapably causes oxidative stress and mitochondrial dysfunction, leading to cell and tissue damage. Increased mitochondrial reactive oxygen species (mtROS) generation triggered by LPS is known to play a key role in the progression of the inflammatory response. mtROS at excessive levels impair electron transport chain functioning, reduce the mitochondrial membrane potential, and initiate lipid peroxidation and oxidative damage of mitochondrial proteins and mtDNA. Over the past 20 years, a large number of mitochondria-targeted antioxidants (mito-AOX) of different structures that can accumulate inside mitochondria and scavenge free radicals have been synthesized. Their protective role based on the prevention of oxidative stress and the restoration of mitochondrial function has been demonstrated in a variety of common diseases and pathological states. This paper reviews the current data on the beneficial application of different mito-AOX in animal endotoxemia models, in either in vivo or in vitro experiments. The results presented in our review demonstrate the promising potential of approaches based on mito-AOX in the development of new treatment strategies against Gram-negative infections and LPS per se.
Citations by journals
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
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European Respiratory Journal
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International Journal of Biochemistry and Cell Biology
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International Journal of Biochemistry and Cell Biology
1 publication, 3.7%
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Journal of Thoracic and Cardiovascular Surgery
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1 publication, 3.7%
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1 publication, 3.7%
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Scientific Reports
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1 publication, 3.7%
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1 publication, 3.7%
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1 publication, 3.7%
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1 publication, 3.7%
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1 publication, 3.7%
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Biomedicine and Pharmacotherapy
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1 publication, 3.7%
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Advanced Science
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1 publication, 3.7%
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Molecular Biology
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1 publication, 3.7%
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Journal of Photochemistry and Photobiology A: Chemistry
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Journal of Photochemistry and Photobiology A: Chemistry
1 publication, 3.7%
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Journal of Nutrition
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Journal of Nutrition
1 publication, 3.7%
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Molecules
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Molecules
1 publication, 3.7%
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Heliyon
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1 publication, 3.7%
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Citations by publishers
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9
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Elsevier
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Elsevier
9 publications, 33.33%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
8 publications, 29.63%
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Springer Nature
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Springer Nature
3 publications, 11.11%
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Wiley
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Wiley
2 publications, 7.41%
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European Respiratory Society (ERS)
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European Respiratory Society (ERS)
1 publication, 3.7%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 3.7%
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Hindawi Limited
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Hindawi Limited
1 publication, 3.7%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 3.7%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Fock E. M., Parnova R. G. Protective Effect of Mitochondria-Targeted Antioxidants against Inflammatory Response to Lipopolysaccharide Challenge: A Review // Pharmaceutics. 2021. Vol. 13. No. 2. p. 144.
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Fock E. M., Parnova R. G. Protective Effect of Mitochondria-Targeted Antioxidants against Inflammatory Response to Lipopolysaccharide Challenge: A Review // Pharmaceutics. 2021. Vol. 13. No. 2. p. 144.
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TY - JOUR
DO - 10.3390/pharmaceutics13020144
UR - https://doi.org/10.3390%2Fpharmaceutics13020144
TI - Protective Effect of Mitochondria-Targeted Antioxidants against Inflammatory Response to Lipopolysaccharide Challenge: A Review
T2 - Pharmaceutics
AU - Fock, Ekaterina M
AU - Parnova, Rimma G.
PY - 2021
DA - 2021/01/22 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 144
IS - 2
VL - 13
PMID - 33499252
SN - 1999-4923
ER -
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@article{2021_Fock,
author = {Ekaterina M Fock and Rimma G. Parnova},
title = {Protective Effect of Mitochondria-Targeted Antioxidants against Inflammatory Response to Lipopolysaccharide Challenge: A Review},
journal = {Pharmaceutics},
year = {2021},
volume = {13},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fpharmaceutics13020144},
number = {2},
pages = {144},
doi = {10.3390/pharmaceutics13020144}
}
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MLA
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Fock, Ekaterina M., and Rimma G. Parnova. “Protective Effect of Mitochondria-Targeted Antioxidants against Inflammatory Response to Lipopolysaccharide Challenge: A Review.” Pharmaceutics, vol. 13, no. 2, Jan. 2021, p. 144. https://doi.org/10.3390%2Fpharmaceutics13020144.