Open Access
Polymers, volume 13, issue 7, pages 1021
Wide-Ranging Multitool Study of Structure and Porosity of PLGA Scaffolds for Tissue Engineering
Buzmakov A. V.
1
,
Dunaev Andrey
1
,
Krivonosov Yuriy
1
,
Zolotov D. A.
1
,
Dyachkova Irina
1
,
Krotova Larisa
1
,
Volkov Vladimir
1
,
Bodey Andrew
2
,
Popov Vladimir
1
1
2
Diamond Light Source, Harwell Oxford Campus, Didcot OX11 0DE, UK
|
Publication type: Journal Article
Publication date: 2021-03-25
General Chemistry
Polymers and Plastics
Abstract
In this study, the nanoscale transformation of the polylactic-co-glycolic acid (PLGA) internal structure, before and after its supercritical carbon dioxide (sc-CO2) swelling and plasticization, followed by foaming after a CO2 pressure drop, was studied by small-angle X-ray scattering (SAXS) for the first time. A comparative analysis of the internal structure data and porosity measurements for PLGA scaffolds, produced by sc-CO2 processing, on a scale ranging from 0.02 to 1000 μm, was performed by SAXS, helium pycnometry (HP), mercury intrusion porosimetry (MIP) and both “lab-source” and synchrotron X-ray microtomography (micro-CT). This approach opens up possibilities for the wide-scale evaluation, computer modeling, and prediction of the physical and mechanical properties of PLGA scaffolds, as well as their biodegradation behavior in the body. Hence, this study targets optimizing the process parameters of PLGA scaffold fabrication for specific biomedical applications.
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Citations by publishers
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Buzmakov A. V. et al. Wide-Ranging Multitool Study of Structure and Porosity of PLGA Scaffolds for Tissue Engineering // Polymers. 2021. Vol. 13. No. 7. p. 1021.
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Buzmakov A. V., Dunaev A., Krivonosov Y., Zolotov D. A., Dyachkova I., Krotova L., Volkov V., Bodey A., Asadchikov V., Popov V. Wide-Ranging Multitool Study of Structure and Porosity of PLGA Scaffolds for Tissue Engineering // Polymers. 2021. Vol. 13. No. 7. p. 1021.
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TY - JOUR
DO - 10.3390/polym13071021
UR - https://doi.org/10.3390%2Fpolym13071021
TI - Wide-Ranging Multitool Study of Structure and Porosity of PLGA Scaffolds for Tissue Engineering
T2 - Polymers
AU - Krivonosov, Yuriy
AU - Krotova, Larisa
AU - Volkov, Vladimir
AU - Bodey, Andrew
AU - Asadchikov, Victor
AU - Popov, Vladimir
AU - Buzmakov, A. V.
AU - Dunaev, Andrey
AU - Zolotov, D. A.
AU - Dyachkova, Irina
PY - 2021
DA - 2021/03/25 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1021
IS - 7
VL - 13
SN - 2073-4360
ER -
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@article{2021_Buzmakov,
author = {Yuriy Krivonosov and Larisa Krotova and Vladimir Volkov and Andrew Bodey and Victor Asadchikov and Vladimir Popov and A. V. Buzmakov and Andrey Dunaev and D. A. Zolotov and Irina Dyachkova},
title = {Wide-Ranging Multitool Study of Structure and Porosity of PLGA Scaffolds for Tissue Engineering},
journal = {Polymers},
year = {2021},
volume = {13},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {mar},
url = {https://doi.org/10.3390%2Fpolym13071021},
number = {7},
pages = {1021},
doi = {10.3390/polym13071021}
}
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MLA
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Buzmakov, A. V., et al. “Wide-Ranging Multitool Study of Structure and Porosity of PLGA Scaffolds for Tissue Engineering.” Polymers, vol. 13, no. 7, Mar. 2021, p. 1021. https://doi.org/10.3390%2Fpolym13071021.
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