Open Access

Sensors, volume 23, issue 14, pages 6352

Reusable SERS Substrates Based on Gold Nanoparticles for Peptide Detection

Qi Zhang ¹

Akhmetzhanov Timur ¹

Pavlova Arina ²

Smirnov Evgeny A. ^{1, 2}

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Department of Material Science, Shenzhen MSU-BIT University, International University Park Road 1, Dayun New Town, Longgang District, Shenzhen 518172, China |

Infochemistry Scientific Center, ITMO University, Lomonosova Str. 9, Saint Petersburg 191002, Russia |

Publication type: Journal Article

Publication date: 2023-07-13

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Sensors

Quartile SCImago

Quartile WOS

Impact factor: 3.9

ISSN: 14243210, 14248220

DOI: 10.3390/s23146352

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PubMed ID: 37514646

Biochemistry

Analytical Chemistry

Atomic and Molecular Physics, and Optics

Electrical and Electronic Engineering

Instrumentation

Abstract

Raman spectroscopy is a powerful analytical technique widely used for quantitative and qualitative analysis. However, the development of inexpensive, reproducible, and reusable enhancing substrates remains a challenge for material scientists and analytical chemists. In this study, we address this challenge by demonstrating the deposition of core–shell nanoparticles consisting of a gold core and a thin inert SiO2 shell within a confined space, resulting in the formation of a highly efficient Raman-enhancing structure. Nanoparticles were characterized by UV–vis spectroscopy, dynamic light scattering, and total reflectance X-ray fluorescence spectroscopy, whereas the prepared substrates were characterized by scanning electron microscopy and Raman spectroscopy with a model molecule, malachite green. The relationship between Raman intensity and the loading of malachite green dye exhibited linearity, indicating the uniform spatial distribution of hotspots across the substrate. The limit of detection was determined as 2.9 μM of malachite green when 10 uL was distributed over a ca. 25 mm2 surface area. Moreover, the same substrate, after thorough washing in ethanol, was successfully employed for the detection of bovine serum albumin at a concentration level of 55 μg mL−1, demonstrating its reusability and versatility. Our findings highlight the potential of these substrates for various applications in biomedical research, clinical diagnosis, and beyond.

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International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 100% International Journal of Molecular Sciences 1 publication, 100%
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Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 100% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 100%
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Qi Zhang et al. Reusable SERS Substrates Based on Gold Nanoparticles for Peptide Detection // Sensors. 2023. Vol. 23. No. 14. p. 6352.

GOST all authors (up to 50) Copy

Qi Zhang, Akhmetzhanov T., Pavlova A., Smirnov E. A. Reusable SERS Substrates Based on Gold Nanoparticles for Peptide Detection // Sensors. 2023. Vol. 23. No. 14. p. 6352.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/s23146352

UR - https://doi.org/10.3390%2Fs23146352

TI - Reusable SERS Substrates Based on Gold Nanoparticles for Peptide Detection

T2 - Sensors

AU - Qi Zhang

AU - Akhmetzhanov, Timur

AU - Pavlova, Arina

AU - Smirnov, Evgeny A.

PY - 2023

DA - 2023/07/13 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 6352

IS - 14

VL - 23

PMID - 37514646

SN - 1424-3210

SN - 1424-8220

ER -

BibTex |

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BibTex Copy

@article{2023_Qi Zhang,

author = {Qi Zhang and Timur Akhmetzhanov and Arina Pavlova and Evgeny A. Smirnov},

title = {Reusable SERS Substrates Based on Gold Nanoparticles for Peptide Detection},

journal = {Sensors},

year = {2023},

volume = {23},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {jul},

url = {https://doi.org/10.3390%2Fs23146352},

number = {14},

pages = {6352},

doi = {10.3390/s23146352}

}

MLA

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MLA Copy

Qi Zhang, et al. “Reusable SERS Substrates Based on Gold Nanoparticles for Peptide Detection.” Sensors, vol. 23, no. 14, Jul. 2023, p. 6352. https://doi.org/10.3390%2Fs23146352.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Sensors

Quartile SCImago

Quartile WOS

Impact factor

3.9

ISSN

14243210 (Print)
14248220 (Electronic)

Labs

Chemotronics and Interfaces Group

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