Open Access

Viruses

, том 13 , издание 7 , страницы 1271

Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes

Тип публикации: Journal Article

Дата публикации: 2021-06-29

MDPI

Viruses

scimago Q1

wos Q2

БС2

SJR: 1.145

CiteScore: 7.7

Impact factor: 3.5

ISSN: 19994915

DOI: 10.3390/v13071271

Скопировать DOI

PubMed ID: 34209981

Infectious Diseases

Virology

Краткое описание

Recent cancer immunotherapy breakthroughs have fundamentally changed oncology and revived the fading hope for a cancer cure. The immune checkpoint inhibitors (ICI) became an indispensable tool for the treatment of many malignant tumors. Alongside ICI, the application of oncolytic viruses in clinical trials is demonstrating encouraging outcomes. Dozens of combinations of oncolytic viruses with conventional radiotherapy and chemotherapy are widely used or studied, but it seems quite complicated to highlight the most effective combinations. Our review summarizes the results of clinical trials evaluating oncolytic viruses with or without genetic alterations in combination with immune checkpoint blockade, cytokines, antigens and other oncolytic viruses as well. This review is focused on the efficacy and safety of virotherapy and the most promising combinations based on the published clinical data, rather than presenting all oncolytic virus variations, which are discussed in comprehensive literature reviews. We briefly revise the research landscape of oncolytic viruses and discuss future perspectives in virus immunotherapy, in order to provide an insight for novel strategies of cancer treatment.

Найдено

3 цитирования

Егоров Александр

🥼 🤝

к.б.н.

17 публикаций, 204 цитирования, 1 рецензия

Индекс Хирша: 9

Научно-технологический университет «Сириус»

Области научных интересов

Молекулярная биология

1 цитирование

Чумаков Петер

52 публикации, 894 цитирования, 1 рецензия

Индекс Хирша: 16

Институт молекулярной биологии им. В.А. Энгельгардта РАН

1 цитирование

Юсубалиева Гаухар

🥼 🤝

к.м.н.

84 публикации, 954 цитирования

Индекс Хирша: 16

Институт молекулярной биологии им. В.А. Энгельгардта РАН

Федеральный центр мозга и нейротехнологий ФМБА России

Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий ФМБА России

Области научных интересов

Иммунотерапия

Клетки CAR-NK

Онколитические вирусы

Стволовые клетки мозга

Экспериментальная онкология

1 цитирование

Пестов Николай

к.х.н.

69 публикаций, 1 086 цитирований, 4 рецензии

Индекс Хирша: 16

Институт биомедицинской химии имени В.Н. Ореховича

Федеральный научный центр исследований и разработки иммунобиологических препаратов им. М. П. Чумакова РАН

Области научных интересов

Белковая инженерия

Топ-30

Журналы

	1 2 3
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 5.66% International Journal of Molecular Sciences 3 публикации, 5.66%
Pharmaceutics	Pharmaceutics, 3, 5.66% Pharmaceutics 3 публикации, 5.66%
Frontiers in Immunology	Frontiers in Immunology, 3, 5.66% Frontiers in Immunology 3 публикации, 5.66%
World Journal of Gastrointestinal Oncology	World Journal of Gastrointestinal Oncology, 2, 3.77% World Journal of Gastrointestinal Oncology 2 публикации, 3.77%
Cancers	Cancers, 2, 3.77% Cancers 2 публикации, 3.77%
Vaccines	Vaccines, 2, 3.77% Vaccines 2 публикации, 3.77%
Acta Naturae	Acta Naturae, 2, 3.77% Acta Naturae 2 публикации, 3.77%
Frontiers in Oncology	Frontiers in Oncology, 2, 3.77% Frontiers in Oncology 2 публикации, 3.77%
Molecular Therapy Oncology	Molecular Therapy Oncology, 2, 3.77% Molecular Therapy Oncology 2 публикации, 3.77%
Future Oncology	Future Oncology, 1, 1.89% Future Oncology 1 публикация, 1.89%
Human Gene Therapy	Human Gene Therapy, 1, 1.89% Human Gene Therapy 1 публикация, 1.89%
Frontiers in Cellular and Infection Microbiology	Frontiers in Cellular and Infection Microbiology, 1, 1.89% Frontiers in Cellular and Infection Microbiology 1 публикация, 1.89%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 1, 1.89% Frontiers in Molecular Biosciences 1 публикация, 1.89%
Paediatric Drugs	Paediatric Drugs, 1, 1.89% Paediatric Drugs 1 публикация, 1.89%
Biotechnology Advances	Biotechnology Advances, 1, 1.89% Biotechnology Advances 1 публикация, 1.89%
Biochimica et Biophysica Acta - Molecular Basis of Disease	Biochimica et Biophysica Acta - Molecular Basis of Disease, 1, 1.89% Biochimica et Biophysica Acta - Molecular Basis of Disease 1 публикация, 1.89%
Advanced Therapeutics	Advanced Therapeutics, 1, 1.89% Advanced Therapeutics 1 публикация, 1.89%
Current Pharmaceutical Biotechnology	Current Pharmaceutical Biotechnology, 1, 1.89% Current Pharmaceutical Biotechnology 1 публикация, 1.89%
Immuno	Immuno, 1, 1.89% Immuno 1 публикация, 1.89%
OncoImmunology	OncoImmunology, 1, 1.89% OncoImmunology 1 публикация, 1.89%
Cancer Research Communications	Cancer Research Communications, 1, 1.89% Cancer Research Communications 1 публикация, 1.89%
International Immunopharmacology	International Immunopharmacology, 1, 1.89% International Immunopharmacology 1 публикация, 1.89%
Life	Life, 1, 1.89% Life 1 публикация, 1.89%
Viruses	Viruses, 1, 1.89% Viruses 1 публикация, 1.89%
European Journal of Pharmacology	European Journal of Pharmacology, 1, 1.89% European Journal of Pharmacology 1 публикация, 1.89%
Molecular Therapy - Oncolytics	Molecular Therapy - Oncolytics, 1, 1.89% Molecular Therapy - Oncolytics 1 публикация, 1.89%
Virology Journal	Virology Journal, 1, 1.89% Virology Journal 1 публикация, 1.89%
Life Sciences	Life Sciences, 1, 1.89% Life Sciences 1 публикация, 1.89%
Journal of Cancer Metastasis and Treatment	Journal of Cancer Metastasis and Treatment, 1, 1.89% Journal of Cancer Metastasis and Treatment 1 публикация, 1.89%
	1 2 3

Издатели

	2 4 6 8 10 12 14
MDPI	MDPI, 13, 24.53% MDPI 13 публикаций, 24.53%
Elsevier	Elsevier, 11, 20.75% Elsevier 11 публикаций, 20.75%
Frontiers Media S.A.	Frontiers Media S.A., 7, 13.21% Frontiers Media S.A. 7 публикаций, 13.21%
Springer Nature	Springer Nature, 7, 13.21% Springer Nature 7 публикаций, 13.21%
Taylor & Francis	Taylor & Francis, 2, 3.77% Taylor & Francis 2 публикации, 3.77%
Baishideng Publishing Group	Baishideng Publishing Group, 2, 3.77% Baishideng Publishing Group 2 публикации, 3.77%
Acta Naturae Ltd	Acta Naturae Ltd, 2, 3.77% Acta Naturae Ltd 2 публикации, 3.77%
Mary Ann Liebert	Mary Ann Liebert, 1, 1.89% Mary Ann Liebert 1 публикация, 1.89%
Wiley	Wiley, 1, 1.89% Wiley 1 публикация, 1.89%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 1, 1.89% Bentham Science Publishers Ltd. 1 публикация, 1.89%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 1, 1.89% American Association for Cancer Research (AACR) 1 публикация, 1.89%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 1.89% Cold Spring Harbor Laboratory 1 публикация, 1.89%
OAE Publishing Inc.	OAE Publishing Inc., 1, 1.89% OAE Publishing Inc. 1 публикация, 1.89%
SCEEMP	SCEEMP, 1, 1.89% SCEEMP 1 публикация, 1.89%
IMR Press	IMR Press, 1, 1.89% IMR Press 1 публикация, 1.89%
Federal Medical Biological Agency	Federal Medical Biological Agency, 1, 1.89% Federal Medical Biological Agency 1 публикация, 1.89%
	2 4 6 8 10 12 14

Мы не учитываем публикации, у которых нет DOI.
Статистика публикаций обновляется еженедельно.

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.

Войти с ORCID

PDF

Метрики

Цитировать

ГОСТ |

Цитировать

ГОСТ Скопировать

Malogolovkin A. et al. Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes // Viruses. 2021. Vol. 13. No. 7. p. 1271.

ГОСТ со всеми авторами (до 50) Скопировать

Malogolovkin A., Gasanov N., Egorov A., Weener M., Ivanov R., Karabelsky A. Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes // Viruses. 2021. Vol. 13. No. 7. p. 1271.

RIS |

Цитировать

RIS Скопировать

TY - JOUR

DO - 10.3390/v13071271

UR - https://doi.org/10.3390/v13071271

TI - Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes

T2 - Viruses

AU - Malogolovkin, Alexander

AU - Gasanov, Nizami

AU - Egorov, Alexander

AU - Weener, Marianna

AU - Ivanov, Roman

AU - Karabelsky, Alexander

PY - 2021

DA - 2021/06/29

PB - MDPI

SP - 1271

IS - 7

VL - 13

PMID - 34209981

SN - 1999-4915

ER -

BibTex |

Цитировать

BibTex (до 50 авторов) Скопировать

@article{2021_Malogolovkin,

author = {Alexander Malogolovkin and Nizami Gasanov and Alexander Egorov and Marianna Weener and Roman Ivanov and Alexander Karabelsky},

title = {Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes},

journal = {Viruses},

year = {2021},

volume = {13},

publisher = {MDPI},

month = {jun},

url = {https://doi.org/10.3390/v13071271},

number = {7},

pages = {1271},

doi = {10.3390/v13071271}

}

MLA

Цитировать

MLA Скопировать

Malogolovkin, Alexander, et al. “Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes.” Viruses, vol. 13, no. 7, Jun. 2021, p. 1271. https://doi.org/10.3390/v13071271.