Open Access

Viruses

, volume 13 , issue 7 , pages 1271

Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes

Alexander Malogolovkin ¹

Nizami Gasanov ¹

Alexander Egorov ¹

Marianna Weener ¹

Roman Ivanov ¹

Alexander Karabelsky ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Gene Therapy Department, Sirius University of Science and Technology, Olympic Avenue, 1, 354340 Sochi, Russia |

Publication type: Journal Article

Publication date: 2021-06-29

MDPI

Viruses

scimago Q1

wos Q2

SJR: 1.145

CiteScore: 7.7

Impact factor: 3.5

ISSN: 19994915

DOI: 10.3390/v13071271

Copy DOI

PubMed ID: 34209981

Infectious Diseases

Virology

Abstract

Recent cancer immunotherapy breakthroughs have fundamentally changed oncology and revived the fading hope for a cancer cure. The immune checkpoint inhibitors (ICI) became an indispensable tool for the treatment of many malignant tumors. Alongside ICI, the application of oncolytic viruses in clinical trials is demonstrating encouraging outcomes. Dozens of combinations of oncolytic viruses with conventional radiotherapy and chemotherapy are widely used or studied, but it seems quite complicated to highlight the most effective combinations. Our review summarizes the results of clinical trials evaluating oncolytic viruses with or without genetic alterations in combination with immune checkpoint blockade, cytokines, antigens and other oncolytic viruses as well. This review is focused on the efficacy and safety of virotherapy and the most promising combinations based on the published clinical data, rather than presenting all oncolytic virus variations, which are discussed in comprehensive literature reviews. We briefly revise the research landscape of oncolytic viruses and discuss future perspectives in virus immunotherapy, in order to provide an insight for novel strategies of cancer treatment.

Found

3 citations

Egorov Alexander

🥼 🤝

PhD in Biological/biomedical sciences

16 publications, 189 citations, 1 review

h-index: 9

Sirius University of Science and Technology

1 citation

Chumakov Peter

52 publications, 872 citations, 1 review

h-index: 16

Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

1 citation

Yusubalieva Gaukhar

🥼 🤝

PhD in Health sciences

84 publications, 922 citations

h-index: 16

Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russia

Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies, FMBA of Russia

Research interests

Brain stem cells

CAR-NK cells

Experimental oncology

Immunotherapy

Oncolytic viruses

1 citation

Pestov Nikolay

PhD in Chemistry

69 publications, 1 075 citations, 4 reviews

h-index: 16

V. N. Orekhovich Research Institute of Biomedical Chemistry

M.P. Chumakov Federal Scientific Center for Research and Development of Immunobiological Drugs of the Russian Academy of Sciences

Research interests

Protein Engineering

Top-30

Journals

	1 2 3
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 6% International Journal of Molecular Sciences 3 publications, 6%
Pharmaceutics	Pharmaceutics, 3, 6% Pharmaceutics 3 publications, 6%
Frontiers in Immunology	Frontiers in Immunology, 3, 6% Frontiers in Immunology 3 publications, 6%
World Journal of Gastrointestinal Oncology	World Journal of Gastrointestinal Oncology, 2, 4% World Journal of Gastrointestinal Oncology 2 publications, 4%
Cancers	Cancers, 2, 4% Cancers 2 publications, 4%
Vaccines	Vaccines, 2, 4% Vaccines 2 publications, 4%
Acta Naturae	Acta Naturae, 2, 4% Acta Naturae 2 publications, 4%
Frontiers in Oncology	Frontiers in Oncology, 2, 4% Frontiers in Oncology 2 publications, 4%
Future Oncology	Future Oncology, 1, 2% Future Oncology 1 publication, 2%
Human Gene Therapy	Human Gene Therapy, 1, 2% Human Gene Therapy 1 publication, 2%
Frontiers in Cellular and Infection Microbiology	Frontiers in Cellular and Infection Microbiology, 1, 2% Frontiers in Cellular and Infection Microbiology 1 publication, 2%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 1, 2% Frontiers in Molecular Biosciences 1 publication, 2%
Paediatric Drugs	Paediatric Drugs, 1, 2% Paediatric Drugs 1 publication, 2%
Biotechnology Advances	Biotechnology Advances, 1, 2% Biotechnology Advances 1 publication, 2%
Biochimica et Biophysica Acta - Molecular Basis of Disease	Biochimica et Biophysica Acta - Molecular Basis of Disease, 1, 2% Biochimica et Biophysica Acta - Molecular Basis of Disease 1 publication, 2%
Advanced Therapeutics	Advanced Therapeutics, 1, 2% Advanced Therapeutics 1 publication, 2%
Current Pharmaceutical Biotechnology	Current Pharmaceutical Biotechnology, 1, 2% Current Pharmaceutical Biotechnology 1 publication, 2%
Immuno	Immuno, 1, 2% Immuno 1 publication, 2%
OncoImmunology	OncoImmunology, 1, 2% OncoImmunology 1 publication, 2%
Cancer Research Communications	Cancer Research Communications, 1, 2% Cancer Research Communications 1 publication, 2%
International Immunopharmacology	International Immunopharmacology, 1, 2% International Immunopharmacology 1 publication, 2%
Life	Life, 1, 2% Life 1 publication, 2%
Viruses	Viruses, 1, 2% Viruses 1 publication, 2%
European Journal of Pharmacology	European Journal of Pharmacology, 1, 2% European Journal of Pharmacology 1 publication, 2%
Molecular Therapy - Oncolytics	Molecular Therapy - Oncolytics, 1, 2% Molecular Therapy - Oncolytics 1 publication, 2%
Virology Journal	Virology Journal, 1, 2% Virology Journal 1 publication, 2%
Life Sciences	Life Sciences, 1, 2% Life Sciences 1 publication, 2%
Journal of Cancer Metastasis and Treatment	Journal of Cancer Metastasis and Treatment, 1, 2% Journal of Cancer Metastasis and Treatment 1 publication, 2%
Safety and Risk of Pharmacotherapy	Safety and Risk of Pharmacotherapy, 1, 2% Safety and Risk of Pharmacotherapy 1 publication, 2%
	1 2 3

Publishers

	2 4 6 8 10 12 14
MDPI	MDPI, 13, 26% MDPI 13 publications, 26%
Elsevier	Elsevier, 10, 20% Elsevier 10 publications, 20%
Frontiers Media S.A.	Frontiers Media S.A., 7, 14% Frontiers Media S.A. 7 publications, 14%
Springer Nature	Springer Nature, 5, 10% Springer Nature 5 publications, 10%
Taylor & Francis	Taylor & Francis, 2, 4% Taylor & Francis 2 publications, 4%
Baishideng Publishing Group	Baishideng Publishing Group, 2, 4% Baishideng Publishing Group 2 publications, 4%
Acta Naturae Ltd	Acta Naturae Ltd, 2, 4% Acta Naturae Ltd 2 publications, 4%
Mary Ann Liebert	Mary Ann Liebert, 1, 2% Mary Ann Liebert 1 publication, 2%
Wiley	Wiley, 1, 2% Wiley 1 publication, 2%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 1, 2% Bentham Science Publishers Ltd. 1 publication, 2%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 1, 2% American Association for Cancer Research (AACR) 1 publication, 2%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 2% Cold Spring Harbor Laboratory 1 publication, 2%
OAE Publishing Inc.	OAE Publishing Inc., 1, 2% OAE Publishing Inc. 1 publication, 2%
SCEEMP	SCEEMP, 1, 2% SCEEMP 1 publication, 2%
IMR Press	IMR Press, 1, 2% IMR Press 1 publication, 2%
Federal Medical Biological Agency	Federal Medical Biological Agency, 1, 2% Federal Medical Biological Agency 1 publication, 2%
	2 4 6 8 10 12 14

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Malogolovkin A. et al. Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes // Viruses. 2021. Vol. 13. No. 7. p. 1271.

GOST all authors (up to 50) Copy

Malogolovkin A., Gasanov N., Egorov A., Weener M., Ivanov R., Karabelsky A. Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes // Viruses. 2021. Vol. 13. No. 7. p. 1271.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.3390/v13071271

UR - https://doi.org/10.3390/v13071271

TI - Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes

T2 - Viruses

AU - Malogolovkin, Alexander

AU - Gasanov, Nizami

AU - Egorov, Alexander

AU - Weener, Marianna

AU - Ivanov, Roman

AU - Karabelsky, Alexander

PY - 2021

DA - 2021/06/29

PB - MDPI

SP - 1271

IS - 7

VL - 13

PMID - 34209981

SN - 1999-4915

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Malogolovkin,

author = {Alexander Malogolovkin and Nizami Gasanov and Alexander Egorov and Marianna Weener and Roman Ivanov and Alexander Karabelsky},

title = {Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes},

journal = {Viruses},

year = {2021},

volume = {13},

publisher = {MDPI},

month = {jun},

url = {https://doi.org/10.3390/v13071271},

number = {7},

pages = {1271},

doi = {10.3390/v13071271}

}

MLA

Cite this

MLA Copy

Malogolovkin, Alexander, et al. “Combinatorial Approaches for Cancer Treatment Using Oncolytic Viruses: Projecting the Perspectives through Clinical Trials Outcomes.” Viruses, vol. 13, no. 7, Jun. 2021, p. 1271. https://doi.org/10.3390/v13071271.

Publisher

MDPI

Journal

Viruses

scimago Q1

wos Q2

SJR

1.145

CiteScore

7.7

Impact factor

3.5

ISSN

19994915 (Print, Electronic)

Labs

Gene therapy

Profiles