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Open access
MDPI
Viruses
,  volume 14 ,  issue 2 ,  pages 437

Application of the CRISPR/Cas9 System to Study Regulation Pathways of the Cellular Immune Response to Influenza Virus

Publication type: Journal Article
Publication date: 2022-02-21
MDPI
scimago Q1
wos Q2
SJR: 1.145
CiteScore: 7.7
Impact factor: 3.5
ISSN: 19994915
DOI:  10.3390/v14020437
PubMed ID:  35216030
Infectious Diseases
Virology
Abstract

Influenza A virus (IAV) causes a respiratory infection that affects millions of people of different age groups and can lead to acute respiratory distress syndrome. Currently, host genes, receptors, and other cellular components critical for IAV replication are actively studied. One of the most convenient and accessible genome-editing tools to facilitate these studies is the CRISPR/Cas9 system. This tool allows for regulating the expression of both viral and host cell genes to enhance or impair viral entry and replication. This review considers the effect of the genome editing system on specific target genes in cells (human and chicken) in terms of subsequent changes in the influenza virus life cycle and the efficiency of virus particle production.

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GOST Copy
Prokhorova D. et al. Application of the CRISPR/Cas9 System to Study Regulation Pathways of the Cellular Immune Response to Influenza Virus // Viruses. 2022. Vol. 14. No. 2. p. 437.
GOST all authors (up to 50) Copy
Prokhorova D., Zhukova (eschenko) N., Lemza A., Sergeeva M. V., Amirkhanov R., Stepanov G. A. Application of the CRISPR/Cas9 System to Study Regulation Pathways of the Cellular Immune Response to Influenza Virus // Viruses. 2022. Vol. 14. No. 2. p. 437.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/v14020437
UR - https://doi.org/10.3390/v14020437
TI - Application of the CRISPR/Cas9 System to Study Regulation Pathways of the Cellular Immune Response to Influenza Virus
T2 - Viruses
AU - Prokhorova, Daria
AU - Zhukova (eschenko), Natalya
AU - Lemza, Anna
AU - Sergeeva, Maria V
AU - Amirkhanov, Rinat
AU - Stepanov, Grigory A
PY - 2022
DA - 2022/02/21
PB - MDPI
SP - 437
IS - 2
VL - 14
PMID - 35216030
SN - 1999-4915
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Prokhorova,
author = {Daria Prokhorova and Natalya Zhukova (eschenko) and Anna Lemza and Maria V Sergeeva and Rinat Amirkhanov and Grigory A Stepanov},
title = {Application of the CRISPR/Cas9 System to Study Regulation Pathways of the Cellular Immune Response to Influenza Virus},
journal = {Viruses},
year = {2022},
volume = {14},
publisher = {MDPI},
month = {feb},
url = {https://doi.org/10.3390/v14020437},
number = {2},
pages = {437},
doi = {10.3390/v14020437}
}
MLA
Cite this
MLA Copy
Prokhorova, Daria, et al. “Application of the CRISPR/Cas9 System to Study Regulation Pathways of the Cellular Immune Response to Influenza Virus.” Viruses, vol. 14, no. 2, Feb. 2022, p. 437. https://doi.org/10.3390/v14020437.