Open Access
1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer
Anton Shetnev
1
,
Sergey Baykov
2
,
Stanislav Kalinin
2
,
Alexandra Belova
1
,
Vladimir Sharoyko
2
,
Anton Rozhkov
2
,
Lev Zelenkov
2
,
Marina Tarasenko
3
,
Evgeny Sadykov
4
,
Mikhail Korsakov
1
,
Mikhail Krasavin
2
Publication type: Journal Article
Publication date: 2019-04-05
scimago Q1
wos Q1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
30959765
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Replacement of amide moiety with the 1,2,4-oxadiazole core in the scaffold of recently reported efflux pump inhibitors afforded a novel series of oxadiazole/2-imidazoline hybrids. The latter compounds exhibited promising antibacterial activity on both Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Escherichia coli, Pseudomonas fluorescens) strains. Furthermore, selected compounds markedly inhibited the growth of certain drug-resistant bacteria. Additionally, the study revealed the antiproliferative activity of several antibacterial frontrunners against pancreas ductal adenocarcinoma (PANC-1) cell line, as well as their type-selective monoamine oxidase (MAO) inhibitory profile.
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37
Total citations:
37
Citations from 2024:
7
(18%)
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BibTex |
MLA
Cite this
GOST
Copy
Shetnev A. et al. 1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer // International Journal of Molecular Sciences. 2019. Vol. 20. No. 7. p. 1699.
GOST all authors (up to 50)
Copy
Shetnev A., Baykov S., Kalinin S., Belova A., Sharoyko V., Rozhkov A., Zelenkov L., Tarasenko M., Sadykov E., Korsakov M., Krasavin M. 1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer // International Journal of Molecular Sciences. 2019. Vol. 20. No. 7. p. 1699.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/IJMS20071699
UR - https://doi.org/10.3390/IJMS20071699
TI - 1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer
T2 - International Journal of Molecular Sciences
AU - Shetnev, Anton
AU - Baykov, Sergey
AU - Kalinin, Stanislav
AU - Belova, Alexandra
AU - Sharoyko, Vladimir
AU - Rozhkov, Anton
AU - Zelenkov, Lev
AU - Tarasenko, Marina
AU - Sadykov, Evgeny
AU - Korsakov, Mikhail
AU - Krasavin, Mikhail
PY - 2019
DA - 2019/04/05
PB - MDPI
SP - 1699
IS - 7
VL - 20
PMID - 30959765
SN - 1661-6596
SN - 1422-0067
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Shetnev,
author = {Anton Shetnev and Sergey Baykov and Stanislav Kalinin and Alexandra Belova and Vladimir Sharoyko and Anton Rozhkov and Lev Zelenkov and Marina Tarasenko and Evgeny Sadykov and Mikhail Korsakov and Mikhail Krasavin},
title = {1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer},
journal = {International Journal of Molecular Sciences},
year = {2019},
volume = {20},
publisher = {MDPI},
month = {apr},
url = {https://doi.org/10.3390/IJMS20071699},
number = {7},
pages = {1699},
doi = {10.3390/IJMS20071699}
}
Cite this
MLA
Copy
Shetnev, Anton, et al. “1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer.” International Journal of Molecular Sciences, vol. 20, no. 7, Apr. 2019, p. 1699. https://doi.org/10.3390/IJMS20071699.