Open Access
6-(Chloromethyl)-n,1-dimethyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine
Publication type: Journal Article
Publication date: 2021-11-01
DOI:
10.3390/M1294
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
Functionally 4,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidines are important compounds with various pharmacological activities. 1-Substituted 4-chloro-6-(chloromethyl)-1H-pyrazolo[3,4-d]pyrimidines are practically unexplored derivatives in this series. In this paper, it was shown that the nucleophilic substitution of 4-Chloro-6-(chloromethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine with methylamine produced selectively 4-substituted product, 6-(chloromethyl)-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. The structure of the synthesized compound was established by elemental analysis, high resolution mass-spectrometry, 1H, 13C-NMR, and IR spectroscopy, mass-spectrometry, and X-ray analysis.
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Ogurtsov V. A., Rakitin O. A. 6-(Chloromethyl)-n,1-dimethyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine // MolBank. 2021. Vol. 2021. No. 4. p. M1294.
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Ogurtsov V. A., Rakitin O. A. 6-(Chloromethyl)-n,1-dimethyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine // MolBank. 2021. Vol. 2021. No. 4. p. M1294.
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TY - JOUR
DO - 10.3390/M1294
UR - https://www.mdpi.com/1422-8599/2021/4/M1294
TI - 6-(Chloromethyl)-n,1-dimethyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine
T2 - MolBank
AU - Ogurtsov, Vladimir A.
AU - Rakitin, Oleg A.
PY - 2021
DA - 2021/11/01
PB - MDPI
SP - M1294
IS - 4
VL - 2021
SN - 1422-8599
ER -
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BibTex (up to 50 authors)
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@article{2021_Ogurtsov,
author = {Vladimir A. Ogurtsov and Oleg A. Rakitin},
title = {6-(Chloromethyl)-n,1-dimethyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine},
journal = {MolBank},
year = {2021},
volume = {2021},
publisher = {MDPI},
month = {nov},
url = {https://www.mdpi.com/1422-8599/2021/4/M1294},
number = {4},
pages = {M1294},
doi = {10.3390/M1294}
}
Cite this
MLA
Copy
Ogurtsov, Vladimir A., and Oleg A. Rakitin. “6-(Chloromethyl)-n,1-dimethyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine.” MolBank, vol. 2021, no. 4, Nov. 2021, p. M1294. https://www.mdpi.com/1422-8599/2021/4/M1294.