Open Access
Marine Drugs, volume 19, issue 10, pages 553
Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage
Chingizova Ekaterina A
1
,
Menchinskaya Ekaterina S
1
,
Chingizov Artur R
2
,
Pislyagin E.A.
1
,
Girich Elena V
3
,
Guzhova Irina V
4
,
Mikhailov Valery V.
2
,
Aminin Dmitry L.
1, 5
,
Publication type: Journal Article
Publication date: 2021-09-29
PubMed ID:
34677452
Drug Discovery
Pharmaceutical Science
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
Cerebrosides are glycosylated sphingolipids, and in mammals they contribute to the pro-/anti-inflammatory properties and innate antimicrobial activity of the skin and mucosal surfaces. Staphylococcus aureus infection can develop, not only from minor scratches of the skin, but this pathogen can also actively promote epithelial breach. The effect of cerebroside flavuside B from marine sediment-derived fungus Penicillium islandicum (Aniva Bay, the Sea of Okhotsk) on viability, apoptosis, total caspase activity, and cell cycle in human epidermal keratinocytes HaCaT line co-cultivated with S. aureus, as well as influence of flavuside B on LPS-treated HaCaT cells were studied. Influence of flavuside B on bacterial growth and biofilm formation of S. aureus and its effect on the enzymatic activity of sortase A was also investigated. It was found S. aureus co-cultivated with keratinocytes induces caspase-depended apoptosis and cell death, arrest cell cycle in the G0/G1 phase, and increases in cellular immune inflammation. Cerebroside flavuside B has demonstrated its antimicrobial and anti-inflammatory properties, substantially eliminating all the negative consequences caused by co-cultivation of keratinocytes with S. aureus or bacterial LPS. The dual action of flavuside B may be highly effective in the treatment of bacterial skin lesions and will be studied in the future in in vivo experiments.
Citations by journals
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1
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3
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Marine Drugs
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Marine Drugs
3 publications, 75%
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Journal of Fungi
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Journal of Fungi
1 publication, 25%
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1
2
3
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 100%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Chingizova E. A. et al. Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage // Marine Drugs. 2021. Vol. 19. No. 10. p. 553.
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Chingizova E. A., Menchinskaya E. S., Chingizov A. R., Pislyagin E., Girich E. V., Yurchenko A. N., Guzhova I. V., Mikhailov V. V., Aminin D. L., YURCHENKO E. Y. Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage // Marine Drugs. 2021. Vol. 19. No. 10. p. 553.
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TY - JOUR
DO - 10.3390/MD19100553
UR - https://doi.org/10.3390%2FMD19100553
TI - Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage
T2 - Marine Drugs
AU - Chingizov, Artur R
AU - Girich, Elena V
AU - Guzhova, Irina V
AU - Mikhailov, Valery V.
AU - Aminin, Dmitry L.
AU - Chingizova, Ekaterina A
AU - Menchinskaya, Ekaterina S
AU - Pislyagin, E.A.
AU - Yurchenko, Anton N
AU - YURCHENKO, EKATERINA Y.
PY - 2021
DA - 2021/09/29 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 553
IS - 10
VL - 19
PMID - 34677452
SN - 1660-3397
ER -
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@article{2021_Chingizova,
author = {Artur R Chingizov and Elena V Girich and Irina V Guzhova and Valery V. Mikhailov and Dmitry L. Aminin and Ekaterina A Chingizova and Ekaterina S Menchinskaya and E.A. Pislyagin and Anton N Yurchenko and EKATERINA Y. YURCHENKO},
title = {Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage},
journal = {Marine Drugs},
year = {2021},
volume = {19},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {sep},
url = {https://doi.org/10.3390%2FMD19100553},
number = {10},
pages = {553},
doi = {10.3390/MD19100553}
}
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MLA
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Chingizova, Ekaterina A., et al. “Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage.” Marine Drugs, vol. 19, no. 10, Sep. 2021, p. 553. https://doi.org/10.3390%2FMD19100553.