Acta Microbiologica Hellenica, volume 69, issue 3, pages 187-203

Clinical and Ocular Inflammatory Inhibitors of Viral-Based Gene Therapy of the Retina

Publication typeJournal Article
Publication date2024-09-11
scimago Q4
SJR0.108
CiteScore0.2
Impact factor
ISSN04389573, 24594113, 28139054
Abstract

Gene therapy is an emerging field of medicine that can target and treat previously untreatable blinding or lethal diseases. Within the field of ophthalmology, gene therapy has emerged to treat retinal degenerative disorders, but its exact role is in its infancy. While this exciting frontier is rapidly expanding, these typically viral-based gene therapy vectors trigger a host immune response. Thus, a better understanding of the host immune response to gene therapies is critical, in that harnessing immunity to these vectors may improve treatment efficacy and reduce the risk of vision loss from inflammation. As such, we will discuss innate and adaptive immunity to gene therapy vectors, and avenues through which this response may be harnessed to improve visual outcomes.

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