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Antioxidants, volume 10, issue 1, pages 120

Propagation of Mitochondria-Derived Reactive Oxygen Species within the Dipodascus magnusii Cells

Rogov Anton G ¹

Goleva Tatiana N ¹

Epremyan Khoren K ¹

Kireev Igor I ²

Zvyagilskaya Renata A. ¹

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Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology” of the Russian Academy of Sciences 33, bld. 2 Leninsky Ave., Moscow 119071, Russia

Bach Institute of Biochemistry of the Russian Academy of Sciences

Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Vorobyevy Gory 1, Moscow 119992, Russia |

Publication type: Journal Article

Publication date: 2021-01-15

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: Antioxidants

Quartile SCImago

Quartile WOS

Impact factor: 7

ISSN: 20763921

DOI: 10.3390/antiox10010120

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PubMed ID: 33467672

Biochemistry

Molecular Biology

Cell Biology

Clinical Biochemistry

Physiology

Abstract

Mitochondria are considered to be the main source of reactive oxygen species (ROS) in the cell. It was shown that in cardiac myocytes exposed to excessive oxidative stress, ROS-induced ROS release is triggered. However, cardiac myocytes have a network of densely packed organelles that do not move, which is not typical for the majority of eukaryotic cells. The purpose of this study was to trace the spatiotemporal development (propagation) of prooxidant-induced oxidative stress and its interplay with mitochondrial dynamics. We used Dipodascus magnusii yeast cells as a model, as they have advantages over other models, including a uniquely large size, mitochondria that are easy to visualize and freely moving, an ability to vigorously grow on well-defined low-cost substrates, and high responsibility. It was shown that prooxidant-induced oxidative stress was initiated in mitochondria, far preceding the appearance of generalized oxidative stress in the whole cell. For yeasts, these findings were obtained for the first time. Preincubation of yeast cells with SkQ1, a mitochondria-addressed antioxidant, substantially diminished production of mitochondrial ROS, while only slightly alleviating the generalized oxidative stress. This was expected, but had not yet been shown. Importantly, mitochondrial fragmentation was found to be primarily induced by mitochondrial ROS preceding the generalized oxidative stress development.

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International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 25% International Journal of Molecular Sciences 2 publications, 25%
Microorganisms	Microorganisms, 1, 12.5% Microorganisms 1 publication, 12.5%
Applied Sciences (Switzerland)	Applied Sciences (Switzerland), 1, 12.5% Applied Sciences (Switzerland) 1 publication, 12.5%
Frontiers in Aging Neuroscience	Frontiers in Aging Neuroscience, 1, 12.5% Frontiers in Aging Neuroscience 1 publication, 12.5%
Journal of Inorganic Biochemistry	Journal of Inorganic Biochemistry, 1, 12.5% Journal of Inorganic Biochemistry 1 publication, 12.5%
Oxidative Medicine and Cellular Longevity	Oxidative Medicine and Cellular Longevity, 1, 12.5% Oxidative Medicine and Cellular Longevity 1 publication, 12.5%
Nanobiotechnology Reports	Nanobiotechnology Reports, 1, 12.5% Nanobiotechnology Reports 1 publication, 12.5%
	1 2

Citations by publishers

	1 2 3 4
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 4, 50% Multidisciplinary Digital Publishing Institute (MDPI) 4 publications, 50%
Frontiers Media S.A.	Frontiers Media S.A., 1, 12.5% Frontiers Media S.A. 1 publication, 12.5%
Elsevier	Elsevier, 1, 12.5% Elsevier 1 publication, 12.5%
Hindawi Limited	Hindawi Limited, 1, 12.5% Hindawi Limited 1 publication, 12.5%
Pleiades Publishing	Pleiades Publishing, 1, 12.5% Pleiades Publishing 1 publication, 12.5%
	1 2 3 4

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Rogov A. G. et al. Propagation of Mitochondria-Derived Reactive Oxygen Species within the Dipodascus magnusii Cells // Antioxidants. 2021. Vol. 10. No. 1. p. 120.

GOST all authors (up to 50) Copy

Rogov A. G., Goleva T. N., Epremyan K. K., Kireev I. I., Zvyagilskaya R. A. Propagation of Mitochondria-Derived Reactive Oxygen Species within the Dipodascus magnusii Cells // Antioxidants. 2021. Vol. 10. No. 1. p. 120.

RIS |

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RIS Copy

TY - JOUR

DO - 10.3390/antiox10010120

UR - https://doi.org/10.3390%2Fantiox10010120

TI - Propagation of Mitochondria-Derived Reactive Oxygen Species within the Dipodascus magnusii Cells

T2 - Antioxidants

AU - Rogov, Anton G

AU - Goleva, Tatiana N

AU - Epremyan, Khoren K

AU - Kireev, Igor I

AU - Zvyagilskaya, Renata A.

PY - 2021

DA - 2021/01/15 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 120

IS - 1

VL - 10

PMID - 33467672

SN - 2076-3921

ER -

BibTex |

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BibTex Copy

@article{2021_Rogov,

author = {Anton G Rogov and Tatiana N Goleva and Khoren K Epremyan and Igor I Kireev and Renata A. Zvyagilskaya},

title = {Propagation of Mitochondria-Derived Reactive Oxygen Species within the Dipodascus magnusii Cells},

journal = {Antioxidants},

year = {2021},

volume = {10},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {jan},

url = {https://doi.org/10.3390%2Fantiox10010120},

number = {1},

pages = {120},

doi = {10.3390/antiox10010120}

}

MLA

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Rogov, Anton G., et al. “Propagation of Mitochondria-Derived Reactive Oxygen Species within the Dipodascus magnusii Cells.” Antioxidants, vol. 10, no. 1, Jan. 2021, p. 120. https://doi.org/10.3390%2Fantiox10010120.

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Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

Antioxidants

Quartile SCImago

Quartile WOS

Impact factor

ISSN

20763921 (Electronic)

Labs

Department of Electron Microscopy

Profiles

Kireev, Igor Igorevich