Open Access
Antioxidants, volume 10, issue 12, pages 1985
Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles
Mollaeva Mariia R
1, 2
,
Nikolskaya Elena D
1, 2
,
Beganovskaya Veronika
1, 3
,
Sokol Maria
1, 2
,
Chirkina Margarita
1, 2
,
Obydennyi S.I.
4, 5
,
Startseva Olga
7
,
Mollaev Murad D
4
,
Yabbarov Nikita
1, 2
1
JSC Russian Research Center for Molecular Diagnostics and Therapy, 117149 Moscow, Russia
|
2
Publication type: Journal Article
Publication date: 2021-12-13
PubMed ID:
34943088
Biochemistry
Molecular Biology
Cell Biology
Clinical Biochemistry
Physiology
Abstract
Pheophorbide a 17-diethylene glycol ester (XL-8), is a promising high-active derivative of known photosensitizer chlorin e6 used in photodynamic therapy. However, high lipophilicity and poor tumor accumulation limit XL-8 therapeutic application. We developed a novel XL-8 loaded with poly(D,L-lactide-co-glycolide) nanoparticles using the single emulsion-solvent evaporation method. The nanoparticles possessed high XL-8 loading content (4.6%) and encapsulation efficiency (87.7%) and a small size (182 ± 19 nm), and negative surface charge (−22.2 ± 3.8 mV) contributed to a specific intracellular accumulation. Sustained biphasic XL-8 release from nanoparticles enhanced the photosensitizer photostability upon irradiation that could potentially reduce the quantity of the drug applied. Additionally, the encapsulation of XL-8 in the polymer matrix preserved phototoxic activity of the payload. The nanoparticles displayed enhanced cellular internalization. Flow cytometry and confocal laser-scanning microscopy studies revealed rapid XL-8 loaded nanoparticles distribution throughout the cell and initiation of DNA damage, glutathione depletion, and lipid peroxidation via reactive oxygen species formation. The novel nanoformulated XL-8 simultaneously revealed a significant phototoxicity accompanied with enhanced photostability, in contrast with traditional photosensitizers, and demonstrated a great potential for further in vivo studies.
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Citations by publishers
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6 publications, 54.55%
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2 publications, 18.18%
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1 publication, 9.09%
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World Scientific
1 publication, 9.09%
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Springer Nature
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Springer Nature
1 publication, 9.09%
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1
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5
6
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Mollaeva M. R. et al. Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles // Antioxidants. 2021. Vol. 10. No. 12. p. 1985.
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Mollaeva M. R., Nikolskaya E. D., Beganovskaya V., Sokol M., Chirkina M., Obydennyi S., Belykh D. V., Startseva O., Mollaev M. D., Yabbarov N. Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles // Antioxidants. 2021. Vol. 10. No. 12. p. 1985.
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TY - JOUR
DO - 10.3390/antiox10121985
UR - https://doi.org/10.3390%2Fantiox10121985
TI - Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles
T2 - Antioxidants
AU - Mollaeva, Mariia R
AU - Beganovskaya, Veronika
AU - Sokol, Maria
AU - Chirkina, Margarita
AU - Mollaev, Murad D
AU - Yabbarov, Nikita
AU - Nikolskaya, Elena D
AU - Obydennyi, S.I.
AU - Belykh, Dmitrii V.
AU - Startseva, Olga
PY - 2021
DA - 2021/12/13 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1985
IS - 12
VL - 10
PMID - 34943088
SN - 2076-3921
ER -
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@article{2021_Mollaeva,
author = {Mariia R Mollaeva and Veronika Beganovskaya and Maria Sokol and Margarita Chirkina and Murad D Mollaev and Nikita Yabbarov and Elena D Nikolskaya and S.I. Obydennyi and Dmitrii V. Belykh and Olga Startseva},
title = {Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles},
journal = {Antioxidants},
year = {2021},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {dec},
url = {https://doi.org/10.3390%2Fantiox10121985},
number = {12},
pages = {1985},
doi = {10.3390/antiox10121985}
}
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MLA
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Mollaeva, Mariia R., et al. “Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles.” Antioxidants, vol. 10, no. 12, Dec. 2021, p. 1985. https://doi.org/10.3390%2Fantiox10121985.