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Bioengineering, том 9, издание 5, номер публикации: 210

Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid

Smirnova Anastassia S. 1, 2
Shevchenko Oksana G. 5
Pestova Svetlana V. 6
Rubtsova Svetlana A. 6
Ostolopovskaya Olga V. 3, 7
Rakhmatullin Ilfat Z. 3
Timerova Ayzira F. 3
Islamov Daut R. 9
Dorovatovskii Pavel V. 10
Тип документаJournal Article
Дата публикации2022-05-12
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Название журналаBioengineering
Квартиль по SCImagoQ2
Квартиль по Web of ScienceQ2
Импакт-фактор 20215.05
Краткое описание
This paper presents the design and a comparative analysis of the structural and solvation factors on the spectral and biological properties of the BODIPY biomarker with a thioterpene fragment. Covalent binding of the thioterpene moiety to the butanoic acid residue of meso-substituted BODIPY was carried out to find out the membranotropic effect of conjugate to erythrocytes, and to assess the possibilities of its practical application in bioimaging. The molecular structure of the conjugate was confirmed via X-ray, UV/vis-, NMR-, and MS-spectra. It was found that dye demonstrates high photostability and high fluorescence quantum yield (to ~100%) at 514–519 nm. In addition, the marker was shown to effectively penetrate the erythrocytes membrane in the absence of erythrotoxicity. The conjugation of BODIPY with thioterpenoid is an excellent way to increase affinity dyes to biostructures, including blood components.
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1. Guseva G. B. и др. Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid // Bioengineering. 2022. Т. 9. № 5. С. 210.


DO - 10.3390/bioengineering9050210

UR -

TI - Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid

T2 - Bioengineering

AU - Guseva, Galina B.

AU - Antina, Elena V.

AU - Berezin, Mikhail B.

AU - Smirnova, Anastassia S.

AU - Pavelyev, Roman S.

AU - Gilfanov, Ilmir R.

AU - Shevchenko, Oksana G.

AU - Pestova, Svetlana V.

AU - Izmest’ev, Evgeny S.

AU - Rubtsova, Svetlana A.

AU - Ostolopovskaya, Olga V.

AU - Efimov, Sergey V.

AU - Klochkov, Vladimir V.

AU - Rakhmatullin, Ilfat Z.

AU - Timerova, Ayzira F.

AU - Khodov, Ilya A.

AU - Lodochnikova, Olga A.

AU - Islamov, Daut R.

AU - Dorovatovskii, Pavel V.

AU - Nikitina, Liliya E.

AU - Boichuk, Sergei V.

PY - 2022

DA - 2022/05/12


SP - 210

IS - 5

VL - 9

SN - 2306-5354

ER -

BibTex |


doi = {10.3390/bioengineering9050210},

url = {},

year = 2022,

month = {may},

publisher = {{MDPI} {AG}},

volume = {9},

number = {5},

pages = {210},

author = {Galina B. Guseva and Elena V. Antina and Mikhail B. Berezin and Anastassia S. Smirnova and Roman S. Pavelyev and Ilmir R. Gilfanov and Oksana G. Shevchenko and Svetlana V. Pestova and Evgeny S. Izmest'ev and Svetlana A. Rubtsova and Olga V. Ostolopovskaya and Sergey V. Efimov and Vladimir V. Klochkov and Ilfat Z. Rakhmatullin and Ayzira F. Timerova and Ilya A. Khodov and Olga A. Lodochnikova and Daut R. Islamov and Pavel V. Dorovatovskii and Liliya E. Nikitina and Sergei V. Boichuk},

title = {Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of {BODIPY} {FL}-Labeled Thioterpenoid},

journal = {Bioengineering}


Guseva, Galina B., et al. “Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid.” Bioengineering, vol. 9, no. 5, May 2022, p. 210. Crossref,