Open Access
Open access
MDPI
Bioengineering
,  volume 9 ,  issue 5 ,  pages 210

Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid

Galina B Guseva 1
, 
Elena V. Antina 1
, 
Mikhail B Berezin 1
, 
Anastassia S Smirnova 1, 2
, 
Roman S. Pavelyev 3
, 
Ilmir R. Gilfanov 3, 4
, 
Oksana G. Shevchenko 5
, 
Svetlana V Pestova 6
, 
Evgeniy S. Izmest’ev 6
, 
Svetlana A. Rubtsova 6
, 
Olga V Ostolopovskaya 3, 7
, 
Sergey Efimov 3
, 
Vladimir V. Klochkov 3
, 
Ilfat Z. Rakhmatullin 3
, 
Ayzira F Timerova 3
, 
Ilya A. Khodov 1
, 
Olga A. Lodochnikova 8
, 
Daut R. Islamov 9
, 
Pavel V. Dorovatovskii 10
, 
Liliya E. Nikitina 3, 7
, 
Sergei Boichuk 3, 7
1
 
2
 
3
 
4
 
5
 
6
 
7
 
8
 
9
 
10
 
Publication type: Journal Article
Publication date: 2022-05-12
MDPI
scimago Q2
wos Q2
SJR: 0.735
CiteScore: 5.3
Impact factor: 3.7
ISSN: 23065354
Bioengineering
Abstract

This paper presents the design and a comparative analysis of the structural and solvation factors on the spectral and biological properties of the BODIPY biomarker with a thioterpene fragment. Covalent binding of the thioterpene moiety to the butanoic acid residue of meso-substituted BODIPY was carried out to find out the membranotropic effect of conjugate to erythrocytes, and to assess the possibilities of its practical application in bioimaging. The molecular structure of the conjugate was confirmed via X-ray, UV/vis-, NMR-, and MS-spectra. It was found that dye demonstrates high photostability and high fluorescence quantum yield (to ~100%) at 514–519 nm. In addition, the marker was shown to effectively penetrate the erythrocytes membrane in the absence of erythrotoxicity. The conjugation of BODIPY with thioterpenoid is an excellent way to increase affinity dyes to biostructures, including blood components.

Found 
Found 
3 citations
Antina Elena
DSc in Chemistry
207 publications,  2 270 citations
h-index: 22
G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
2 citations
Ksenofontov Alexander
🥼 🤝
PhD in Chemistry
104 publications,  1 115 citations,  54 reviews
h-index: 17
G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
Research interests
Computational chemistry
Coordination Chemistry
Data Science
Fluorescence
Machine learning
Photochemistry
Physical Chemistry
2 citations
Eremeeva Yulia
11 publications,  39 citations
h-index: 3
G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
Research interests
Absorption spectroscopy
Antimicrobial resistance
BODIPY
Luminescence
1 citation
Babaeva Olga
PhD in Chemistry
56 publications,  436 citations
h-index: 12
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
A.E. Arbuzov Institute of Organic and Physical Chemistry of the Kazan Scientific Center of the Russian Academy of Sciences
Research interests
Organic Chemistry
Physical Chemistry

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GOST Copy
Guseva G. B. et al. Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid // Bioengineering. 2022. Vol. 9. No. 5. p. 210.
GOST all authors (up to 50) Copy
Guseva G. B., Antina E. V., Berezin M. B., Smirnova A. S., Pavelyev R. S., Gilfanov I. R., Shevchenko O. G., Pestova S. V., Izmest’ev E. S., Rubtsova S. A., Ostolopovskaya O. V., Efimov S., Klochkov V. V., Rakhmatullin I. Z., Timerova A. F., Khodov I. A., Lodochnikova O. A., Islamov D. R., Dorovatovskii P. V., Nikitina L. E., Boichuk S. Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid // Bioengineering. 2022. Vol. 9. No. 5. p. 210.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.3390/bioengineering9050210
UR - https://doi.org/10.3390/bioengineering9050210
TI - Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid
T2 - Bioengineering
AU - Guseva, Galina B
AU - Antina, Elena V.
AU - Berezin, Mikhail B
AU - Smirnova, Anastassia S
AU - Pavelyev, Roman S.
AU - Gilfanov, Ilmir R.
AU - Shevchenko, Oksana G.
AU - Pestova, Svetlana V
AU - Izmest’ev, Evgeniy S.
AU - Rubtsova, Svetlana A.
AU - Ostolopovskaya, Olga V
AU - Efimov, Sergey
AU - Klochkov, Vladimir V.
AU - Rakhmatullin, Ilfat Z.
AU - Timerova, Ayzira F
AU - Khodov, Ilya A.
AU - Lodochnikova, Olga A.
AU - Islamov, Daut R.
AU - Dorovatovskii, Pavel V.
AU - Nikitina, Liliya E.
AU - Boichuk, Sergei
PY - 2022
DA - 2022/05/12
PB - MDPI
SP - 210
IS - 5
VL - 9
PMID - 35621488
SN - 2306-5354
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2022_Guseva,
author = {Galina B Guseva and Elena V. Antina and Mikhail B Berezin and Anastassia S Smirnova and Roman S. Pavelyev and Ilmir R. Gilfanov and Oksana G. Shevchenko and Svetlana V Pestova and Evgeniy S. Izmest’ev and Svetlana A. Rubtsova and Olga V Ostolopovskaya and Sergey Efimov and Vladimir V. Klochkov and Ilfat Z. Rakhmatullin and Ayzira F Timerova and Ilya A. Khodov and Olga A. Lodochnikova and Daut R. Islamov and Pavel V. Dorovatovskii and Liliya E. Nikitina and Sergei Boichuk},
title = {Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid},
journal = {Bioengineering},
year = {2022},
volume = {9},
publisher = {MDPI},
month = {may},
url = {https://doi.org/10.3390/bioengineering9050210},
number = {5},
pages = {210},
doi = {10.3390/bioengineering9050210}
}
MLA
Cite this
MLA Copy
Guseva, Galina B., et al. “Design, Spectral Characteristics, Photostability, and Possibilities for Practical Application of BODIPY FL-Labeled Thioterpenoid.” Bioengineering, vol. 9, no. 5, May. 2022, p. 210. https://doi.org/10.3390/bioengineering9050210.