Open Access
Biomolecules, volume 10, issue 6, pages 873
Human telomerase RNA: Telomerase component or more?
Rubtsova Maria
1, 2
,
Dontsova Olga
1, 2, 3
Publication type: Journal Article
Publication date: 2020-06-06
PubMed ID:
32517215
Biochemistry
Molecular Biology
Abstract
Telomerase is a ribonucleoprotein complex that maintains the lengths of telomeres. Most studies of telomerase function have focused on the involvement of telomerase activation in the immortalization of cancer cells and cellular rejuvenation. However, some studies demonstrated that the results do not meet expectations for telomerase action in telomere maintenance. Recent results give reason to think that major telomerase components—the reverse transcriptase protein subunit and telomerase RNA—may participate in many cellular processes, including the regulation of apoptosis and autophagy, cell survival, pro-proliferative effects, regulation of gene expression, and protection against oxidative stress. However, the difficulties faced by scientist when researching telomerase component functions often reduce confidence in the minor effects observed in experiments. In this review, we focus on the analysis of the functions of telomerase components (paying more attention to the telomerase RNA component), both as a complex and as independent components, providing effects that are not associated with telomerase activity and telomere length maintenance. Despite the fact that the data on alternative roles of telomerase components look illusory, it would be wrong to completely reject the possibility of their involvement in other biological processes excluded from research/discussion. Investigations to improve the understanding of every aspect of the functioning of telomerase components will provide the basis for a more precise development of approaches to regulate cellular homeostasis, which is important for carcinogenesis and aging.
Citations by journals
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1
2
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Genes
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Genes
2 publications, 13.33%
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Frontiers in Cell and Developmental Biology
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Frontiers in Cell and Developmental Biology
1 publication, 6.67%
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Biomedicines
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Biomedicines
1 publication, 6.67%
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Biomolecules
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Biomolecules
1 publication, 6.67%
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Frontiers in Genetics
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Frontiers in Genetics
1 publication, 6.67%
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Biochimie
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Biochimie
1 publication, 6.67%
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Heliyon
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Heliyon
1 publication, 6.67%
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Bioactive Materials
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Bioactive Materials
1 publication, 6.67%
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Journal of Genetic Engineering and Biotechnology
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Journal of Genetic Engineering and Biotechnology
1 publication, 6.67%
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Biochemistry
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Biochemistry
1 publication, 6.67%
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1
2
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 26.67%
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 13.33%
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Elsevier
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Elsevier
2 publications, 13.33%
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KeAi Communications Co.
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KeAi Communications Co.
1 publication, 6.67%
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Springer Nature
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Springer Nature
1 publication, 6.67%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 6.67%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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TY - JOUR
DO - 10.3390/biom10060873
UR - https://doi.org/10.3390%2Fbiom10060873
TI - Human telomerase RNA: Telomerase component or more?
T2 - Biomolecules
AU - Rubtsova, Maria
AU - Dontsova, Olga
PY - 2020
DA - 2020/06/06 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 873
IS - 6
VL - 10
PMID - 32517215
SN - 2218-273X
ER -
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@article{2020_Rubtsova,
author = {Maria Rubtsova and Olga Dontsova},
title = {Human telomerase RNA: Telomerase component or more?},
journal = {Biomolecules},
year = {2020},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fbiom10060873},
number = {6},
pages = {873},
doi = {10.3390/biom10060873}
}
Cite this
MLA
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Rubtsova, Maria, et al. “Human telomerase RNA: Telomerase component or more?.” Biomolecules, vol. 10, no. 6, Jun. 2020, p. 873. https://doi.org/10.3390%2Fbiom10060873.
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