Open Access
Biomedicines, volume 10, issue 2, pages 461
Synthesis, Structure, and Antiproliferative Action of 2-Pyridyl Urea-Based Cu(II) Complexes.
Geyl Kirill K
1
,
Baykov Sergey V
1
,
Kalinin Stanislav
1, 2
,
Troshina Marina A.
2
,
Sharonova Tatiana V
1
,
Skripkin M. Yu.
1
,
Presnukhina Sofia I
1, 3
,
Shetnev Anton A
3
,
Krasavin Mikhail
1
,
Publication type: Journal Article
Publication date: 2022-02-16
PubMed ID:
35203671
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Abstract
Relying on a recently suggested protocol that furnishes convenient access to variously substituted 2-pyridyl ureas, twelve hitherto unknown Cu(II) complexes have been synthesized in the present work and their structures were evaluated by elemental analysis, HRMS, IR spectroscopy, and X-ray diffraction study. Two structural motifs ([Cu(L)2Cl]+[Cl]− or (Cu(L)2Cl2) depending on the substitution pattern on the 2-pyridine fragment were revealed. In addition, antiproliferative action of the obtained compounds have been investigated against lung cancer cell lines (A549, NCI-H460, NCI-H1975), and healthy WI-26 VA4 cells were used to monitor non-specific cytotoxicity. Two nitro-group substituted complexes Cu(U3)2Cl2 (IC50 = 39.6 ± 4.5 μM) and Cu(U11)2Cl2 (IC50 = 33.4 ± 3.8 μM) demonstrate enhanced activity against the drug resistant NCI-H1975 cells with moderate selectivity toward normal WI-26 VA4 cells. The antiproliferative mechanism of cell death underlying the growth inhibitory effect of the synthesized complexes was studied via additional experiments, including the cell cycle analysis and the apoptosis induction test. Reassuringly, certain 2-pyridyl urea-based Cu(II) complexes exerted cell line-specific antiproliferative effect which renders them valuable starting points for further unveiling the anticancer potential of this class of coordination compounds.
Citations by journals
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2
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
2 publications, 20%
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Advanced Synthesis and Catalysis
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Advanced Synthesis and Catalysis
1 publication, 10%
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Inorganics
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Inorganics
1 publication, 10%
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Biomedicines
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1 publication, 10%
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European Journal of Medicinal Chemistry
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European Journal of Medicinal Chemistry
1 publication, 10%
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Toxicology
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Toxicology
1 publication, 10%
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Journal of Coordination Chemistry
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Journal of Coordination Chemistry
1 publication, 10%
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New Journal of Chemistry
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New Journal of Chemistry
1 publication, 10%
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Russian Journal of General Chemistry
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Russian Journal of General Chemistry
1 publication, 10%
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2
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Citations by publishers
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1
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4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 40%
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Elsevier
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Elsevier
2 publications, 20%
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Wiley
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Wiley
1 publication, 10%
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Taylor & Francis
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Taylor & Francis
1 publication, 10%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 10%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 10%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Geyl K. K. et al. Synthesis, Structure, and Antiproliferative Action of 2-Pyridyl Urea-Based Cu(II) Complexes. // Biomedicines. 2022. Vol. 10. No. 2. p. 461.
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Geyl K. K., Baykov S. V., Kalinin S., Bunev A. S., Troshina M. A., Sharonova T. V., Skripkin M. Y., Kasatkina S. O., Presnukhina S. I., Shetnev A. A., Krasavin M., Boyarskiy V. P. Synthesis, Structure, and Antiproliferative Action of 2-Pyridyl Urea-Based Cu(II) Complexes. // Biomedicines. 2022. Vol. 10. No. 2. p. 461.
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TY - JOUR
DO - 10.3390/biomedicines10020461
UR - https://doi.org/10.3390%2Fbiomedicines10020461
TI - Synthesis, Structure, and Antiproliferative Action of 2-Pyridyl Urea-Based Cu(II) Complexes.
T2 - Biomedicines
AU - Geyl, Kirill K
AU - Sharonova, Tatiana V
AU - Presnukhina, Sofia I
AU - Kasatkina, Svetlana O
AU - Troshina, Marina A.
AU - Baykov, Sergey V
AU - Kalinin, Stanislav
AU - Bunev, Alexander S.
AU - Skripkin, M. Yu.
AU - Shetnev, Anton A
AU - Krasavin, Mikhail
AU - Boyarskiy, Vadim P
PY - 2022
DA - 2022/02/16 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 461
IS - 2
VL - 10
PMID - 35203671
SN - 2227-9059
ER -
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@article{2022_Geyl,
author = {Kirill K Geyl and Tatiana V Sharonova and Sofia I Presnukhina and Svetlana O Kasatkina and Marina A. Troshina and Sergey V Baykov and Stanislav Kalinin and Alexander S. Bunev and M. Yu. Skripkin and Anton A Shetnev and Mikhail Krasavin and Vadim P Boyarskiy},
title = {Synthesis, Structure, and Antiproliferative Action of 2-Pyridyl Urea-Based Cu(II) Complexes.},
journal = {Biomedicines},
year = {2022},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {feb},
url = {https://doi.org/10.3390%2Fbiomedicines10020461},
number = {2},
pages = {461},
doi = {10.3390/biomedicines10020461}
}
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Geyl, Kirill K., et al. “Synthesis, Structure, and Antiproliferative Action of 2-Pyridyl Urea-Based Cu(II) Complexes..” Biomedicines, vol. 10, no. 2, Feb. 2022, p. 461. https://doi.org/10.3390%2Fbiomedicines10020461.