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Biomedicines, том 10, издание 6, номер публикации: 1275

Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA

Тип документаJournal Article
Дата публикации2022-05-30
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Название журналаBiomedicines
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ2
Импакт-фактор 20214.76
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Краткое описание
Telomerase RNA has long been considered to be a noncoding component of telomerase. However, the expression of the telomerase RNA gene is not always associated with telomerase activity. The existence of distinct TERC gene expression products possessing different functions were demonstrated recently. During biogenesis, hTR is processed by distinct pathways and localized in different cell compartments, depending on whether it functions as a telomerase complex component or facilitates antistress activities as a noncoding RNA, in which case it is either processed in the mitochondria or translated. In order to identify the factors responsible for the appearance and localization of the exact isoform of hTR, we investigated the roles of the factors regulating transcription DSIF (Spt5) and NELF-E; exosome-attracting factors ZCCHC7, ZCCHC8, and ZFC3H1; ARS2, which attracts processing and transport factors; and transport factor PHAX during the biogenesis of hTR. The data obtained revealed that ZFC3H1 participates in hTR biogenesis via pathways related to the polyadenylated RNA degradation mechanism. The data revealed essential differences that are important for understanding hTR biogenesis and that are interesting for further investigations of new, therapeutically significant targets.
Пристатейные ссылки: 31
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1. Pakhomova T. и др. Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA // Biomedicines. 2022. Т. 10. № 6. С. 1275.


DO - 10.3390/biomedicines10061275

UR -

TI - Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA

T2 - Biomedicines

AU - Pakhomova, Tatiana

AU - Moshareva, Maria

AU - Vasilkova, Daria

AU - Zatsepin, Timofey

AU - Dontsova, Olga

AU - Rubtsova, Maria

PY - 2022

DA - 2022/05/30


SP - 1275

IS - 6

VL - 10

SN - 2227-9059

ER -

BibTex |


doi = {10.3390/biomedicines10061275},

url = {},

year = 2022,

month = {may},

publisher = {{MDPI} {AG}},

volume = {10},

number = {6},

pages = {1275},

author = {Tatiana Pakhomova and Maria Moshareva and Daria Vasilkova and Timofey Zatsepin and Olga Dontsova and Maria Rubtsova},

title = {Role of {RNA} Biogenesis Factors in the Processing and Transport of Human Telomerase {RNA}},

journal = {Biomedicines}


Pakhomova, Tatiana, et al. “Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA.” Biomedicines, vol. 10, no. 6, May 2022, p. 1275. Crossref,