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Biomedicines, volume 10, issue 6, pages 1275

Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA

Publication typeJournal Article
Publication date2022-05-30
Journal: Biomedicines
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor4.7
ISSN22279059
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Abstract

Telomerase RNA has long been considered to be a noncoding component of telomerase. However, the expression of the telomerase RNA gene is not always associated with telomerase activity. The existence of distinct TERC gene expression products possessing different functions were demonstrated recently. During biogenesis, hTR is processed by distinct pathways and localized in different cell compartments, depending on whether it functions as a telomerase complex component or facilitates antistress activities as a noncoding RNA, in which case it is either processed in the mitochondria or translated. In order to identify the factors responsible for the appearance and localization of the exact isoform of hTR, we investigated the roles of the factors regulating transcription DSIF (Spt5) and NELF-E; exosome-attracting factors ZCCHC7, ZCCHC8, and ZFC3H1; ARS2, which attracts processing and transport factors; and transport factor PHAX during the biogenesis of hTR. The data obtained revealed that ZFC3H1 participates in hTR biogenesis via pathways related to the polyadenylated RNA degradation mechanism. The data revealed essential differences that are important for understanding hTR biogenesis and that are interesting for further investigations of new, therapeutically significant targets.

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Citations by publishers

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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
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GOST |
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GOST Copy
Pakhomova T. et al. Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA // Biomedicines. 2022. Vol. 10. No. 6. p. 1275.
GOST all authors (up to 50) Copy
Pakhomova T., Moshareva M., Vasilkova D., Zatsepin T. S., Dontsova O., Rubtsova M. Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA // Biomedicines. 2022. Vol. 10. No. 6. p. 1275.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/biomedicines10061275
UR - https://doi.org/10.3390%2Fbiomedicines10061275
TI - Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA
T2 - Biomedicines
AU - Moshareva, Maria
AU - Vasilkova, Daria
AU - Rubtsova, Maria
AU - Dontsova, Olga
AU - Pakhomova, Tatiana
AU - Zatsepin, Timofei S.
PY - 2022
DA - 2022/05/30 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1275
IS - 6
VL - 10
PMID - 35740297
SN - 2227-9059
ER -
BibTex |
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BibTex Copy
@article{2022_Pakhomova
author = {Maria Moshareva and Daria Vasilkova and Maria Rubtsova and Olga Dontsova and Tatiana Pakhomova and Timofei S. Zatsepin},
title = {Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA},
journal = {Biomedicines},
year = {2022},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {may},
url = {https://doi.org/10.3390%2Fbiomedicines10061275},
number = {6},
pages = {1275},
doi = {10.3390/biomedicines10061275}
}
MLA
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MLA Copy
Pakhomova, Tatiana, et al. “Role of RNA Biogenesis Factors in the Processing and Transport of Human Telomerase RNA.” Biomedicines, vol. 10, no. 6, May. 2022, p. 1275. https://doi.org/10.3390%2Fbiomedicines10061275.
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