Open Access
Biomedicines, volume 10, issue 7, pages 1650
How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript
Rubtsova Maria
1, 2
,
Dontsova Olga
1, 2, 3
Publication type: Journal Article
Publication date: 2022-07-08
PubMed ID:
35884955
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Abstract
Telomerase RNA has been uncovered as a component of the telomerase enzyme, which acts as a reverse transcriptase and maintains the length of telomeres in proliferated eukaryotic cells. Telomerase RNA is considered to have major functions as a template for telomeric repeat synthesis and as a structural scaffold for telomerase. However, investigations of its biogenesis and turnover, as well as structural data, have provided evidence of functions of telomerase RNA that are not associated with telomerase activity. The primary transcript produced from the human telomerase RNA gene encodes for the hTERP protein, which presents regulatory functions related to autophagy, cellular proliferation, and metabolism. This review focuses on the specific features relating to the biogenesis and structure of human telomerase RNA that support the existence of an isoform suitable for functioning as an mRNA. We believe that further investigation into human telomerase RNA biogenesis mechanisms will provide more levels for manipulating cellular homeostasis, survival, and transformation mechanisms, and may contribute to a deeper understanding of the mechanisms of aging.
Citations by journals
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1
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 50%
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Biomedicines
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Biomedicines
1 publication, 50%
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1
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 100%
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1
2
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Rubtsova M. et al. How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript // Biomedicines. 2022. Vol. 10. No. 7. p. 1650.
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Rubtsova M., Dontsova O. How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript // Biomedicines. 2022. Vol. 10. No. 7. p. 1650.
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TY - JOUR
DO - 10.3390/biomedicines10071650
UR - https://doi.org/10.3390%2Fbiomedicines10071650
TI - How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript
T2 - Biomedicines
AU - Rubtsova, Maria
AU - Dontsova, Olga
PY - 2022
DA - 2022/07/08 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1650
IS - 7
VL - 10
PMID - 35884955
SN - 2227-9059
ER -
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@article{2022_Rubtsova,
author = {Maria Rubtsova and Olga Dontsova},
title = {How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript},
journal = {Biomedicines},
year = {2022},
volume = {10},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jul},
url = {https://doi.org/10.3390%2Fbiomedicines10071650},
number = {7},
pages = {1650},
doi = {10.3390/biomedicines10071650}
}
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Rubtsova, Maria, et al. “How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript.” Biomedicines, vol. 10, no. 7, Jul. 2022, p. 1650. https://doi.org/10.3390%2Fbiomedicines10071650.
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