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Biomedicines, том 10, издание 7, номер публикации: 1650

How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript

Тип документаJournal Article
Дата публикации2022-07-08
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Название журналаBiomedicines
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ2
Импакт-фактор 20214.76
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Краткое описание
Telomerase RNA has been uncovered as a component of the telomerase enzyme, which acts as a reverse transcriptase and maintains the length of telomeres in proliferated eukaryotic cells. Telomerase RNA is considered to have major functions as a template for telomeric repeat synthesis and as a structural scaffold for telomerase. However, investigations of its biogenesis and turnover, as well as structural data, have provided evidence of functions of telomerase RNA that are not associated with telomerase activity. The primary transcript produced from the human telomerase RNA gene encodes for the hTERP protein, which presents regulatory functions related to autophagy, cellular proliferation, and metabolism. This review focuses on the specific features relating to the biogenesis and structure of human telomerase RNA that support the existence of an isoform suitable for functioning as an mRNA. We believe that further investigation into human telomerase RNA biogenesis mechanisms will provide more levels for manipulating cellular homeostasis, survival, and transformation mechanisms, and may contribute to a deeper understanding of the mechanisms of aging.
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1. Rubtsova M., Dontsova O. How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript // Biomedicines. 2022. Т. 10. № 7. С. 1650.


DO - 10.3390/biomedicines10071650

UR -

TI - How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript

T2 - Biomedicines

AU - Rubtsova, Maria

AU - Dontsova, Olga

PY - 2022

DA - 2022/07/08


SP - 1650

IS - 7

VL - 10

SN - 2227-9059

ER -

BibTex |


doi = {10.3390/biomedicines10071650},

url = {},

year = 2022,

month = {jul},

publisher = {{MDPI} {AG}},

volume = {10},

number = {7},

pages = {1650},

author = {Maria Rubtsova and Olga Dontsova},

title = {How Structural Features Define Biogenesis and Function of Human Telomerase {RNA} Primary Transcript},

journal = {Biomedicines}


Rubtsova, Maria, and Olga Dontsova. “How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript.” Biomedicines, vol. 10, no. 7, July 2022, p. 1650. Crossref,