Open Access
Biomedicines, volume 9, issue 8, pages 853
Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis
Fayzullin Alexey
1, 2, 3, 4
,
Churbanov S.N.
5
,
Zakharkina Olga
7
,
Tokarev Mark
8
,
Mudryak Daniil
8
,
Khristidis Yana
2
,
Balyasin M.V.
1
,
Kurkov Alexandr
1
,
Aksenova N A
5, 9
,
Dyuzheva Tatyana
8
,
Timashev Petr S.
5, 6, 7, 9, 10
,
Guller Anna
1, 2, 3, 4
,
Shekhter Anatoly
1
4
The Faculty of Medicine, Health and Human Sciences, Macquarie University, Macquarie Park, Sydney, NSW 2060, Australia
|
6
7
8
Publication type: Journal Article
Publication date: 2021-07-21
PubMed ID:
34440057
General Biochemistry, Genetics and Molecular Biology
Medicine (miscellaneous)
Abstract
Peri-implant fibrosis (PIF) increases the postsurgical risks after implantation and limits the efficacy of the implantable drug delivery systems (IDDS). Pirfenidone (PF) is an oral anti-fibrotic drug with a short (<3 h) circulation half-life and strong adverse side effects. In the current study, disk-shaped IDDS prototype combining polylactic acid (PLA) and PF, PLA@PF, with prolonged (~3 days) PF release (in vitro) was prepared. The effects of the PLA@PF implants on PIF were examined in the rabbit ear skin pocket model on postoperative days (POD) 30 and 60. Matching blank PLA implants (PLA0) and PLA0 with an equivalent single-dose PF injection performed on POD0 (PLA0+injPF) served as control. On POD30, the intergroup differences were observed in α-SMA, iNOS and arginase-1 expressions in PLA@PF and PLA0+injPF groups vs. PLA0. On POD60, PIF was significantly reduced in PLA@PF group. The peri-implant tissue thickness decreased (532 ± 98 μm vs. >1100 μm in control groups) approaching the intact derma thickness value (302 ± 15 μm). In PLA@PF group, the implant biodegradation developed faster, while arginase-1 expression was suppressed in comparison with other groups. This study proves the feasibility of the local control of fibrotic response on implants via modulation of foreign body reaction with slowly biodegradable PF-loaded IDDS.
Citations by journals
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Citations by publishers
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1
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Fayzullin A. et al. Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis // Biomedicines. 2021. Vol. 9. No. 8. p. 853.
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Fayzullin A., Churbanov S., Ignatieva N., Zakharkina O., Tokarev M., Mudryak D., Khristidis Y., Balyasin M., Kurkov A., Golubeva E. N., Aksenova N. A., Dyuzheva T., Timashev P. S., Guller A., Shekhter A. Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis // Biomedicines. 2021. Vol. 9. No. 8. p. 853.
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TY - JOUR
DO - 10.3390/biomedicines9080853
UR - https://doi.org/10.3390%2Fbiomedicines9080853
TI - Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis
T2 - Biomedicines
AU - Zakharkina, Olga
AU - Khristidis, Yana
AU - Dyuzheva, Tatyana
AU - Tokarev, Mark
AU - Golubeva, Elena N.
AU - Ignatieva, Natalia
AU - Kurkov, Alexandr
AU - Shekhter, Anatoly
AU - Fayzullin, Alexey
AU - Churbanov, S.N.
AU - Mudryak, Daniil
AU - Balyasin, M.V.
AU - Aksenova, N A
AU - Timashev, Petr S.
AU - Guller, Anna
PY - 2021
DA - 2021/07/21 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 853
IS - 8
VL - 9
PMID - 34440057
SN - 2227-9059
ER -
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@article{2021_Fayzullin,
author = {Olga Zakharkina and Yana Khristidis and Tatyana Dyuzheva and Mark Tokarev and Elena N. Golubeva and Natalia Ignatieva and Alexandr Kurkov and Anatoly Shekhter and Alexey Fayzullin and S.N. Churbanov and Daniil Mudryak and M.V. Balyasin and N A Aksenova and Petr S. Timashev and Anna Guller},
title = {Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis},
journal = {Biomedicines},
year = {2021},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jul},
url = {https://doi.org/10.3390%2Fbiomedicines9080853},
number = {8},
pages = {853},
doi = {10.3390/biomedicines9080853}
}
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Fayzullin, Alexey, et al. “Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis.” Biomedicines, vol. 9, no. 8, Jul. 2021, p. 853. https://doi.org/10.3390%2Fbiomedicines9080853.