Open Access
TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems
Publication type: Journal Article
Publication date: 2022-10-19
PubMed ID:
36291908
Cancer Research
Oncology
Abstract
The death ligand tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF cytokine superfamily, has long been recognized for its potential as a cancer therapeutic due to its low toxicity against normal cells. However, its translation into a therapeutic molecule has not been successful to date, due to its short in vivo half-life associated with insufficient tumor accumulation and resistance of tumor cells to TRAIL-induced killing. Nanotechnology has the capacity to offer solutions to these limitations. This review provides a perspective and a critical assessment of the most promising approaches to realize TRAIL’s potential as an anticancer therapeutic, including the development of fusion constructs, encapsulation, nanoparticle functionalization and tumor-targeting, and discusses the current challenges and future perspectives.
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Metrics
31
Total citations:
31
Citations from 2024:
23
(76%)
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Alizadeh Zeinabad H., Szegezdi E. TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems // Cancers. 2022. Vol. 14. No. 20. p. 5125.
GOST all authors (up to 50)
Copy
Alizadeh Zeinabad H., Szegezdi E. TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems // Cancers. 2022. Vol. 14. No. 20. p. 5125.
Cite this
RIS
Copy
TY - JOUR
DO - 10.3390/cancers14205125
UR - https://doi.org/10.3390/cancers14205125
TI - TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems
T2 - Cancers
AU - Alizadeh Zeinabad, Hojjat
AU - Szegezdi, Eva
PY - 2022
DA - 2022/10/19
PB - MDPI
SP - 5125
IS - 20
VL - 14
PMID - 36291908
SN - 2072-6694
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Alizadeh Zeinabad,
author = {Hojjat Alizadeh Zeinabad and Eva Szegezdi},
title = {TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems},
journal = {Cancers},
year = {2022},
volume = {14},
publisher = {MDPI},
month = {oct},
url = {https://doi.org/10.3390/cancers14205125},
number = {20},
pages = {5125},
doi = {10.3390/cancers14205125}
}
Cite this
MLA
Copy
Alizadeh Zeinabad, Hojjat, et al. “TRAIL in the Treatment of Cancer: From Soluble Cytokine to Nanosystems.” Cancers, vol. 14, no. 20, Oct. 2022, p. 5125. https://doi.org/10.3390/cancers14205125.