Open Access
Cells, volume 9, issue 7, pages 1675
Evolution of Regulated Transcription
Publication type: Journal Article
Publication date: 2020-07-12
PubMed ID:
32664620
General Medicine
Abstract
The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and precisely orchestrate gene expression programs. Here, we follow gradual evolution of this regulatory system and discuss its features in different organisms. In eubacteria, an enhancer-like element is often a single regulatory element, is usually proximal to the core promoter, and is occupied by one or a few activators. Activation of gene expression in archaea is accompanied by the recruitment of an activator to several enhancer-like sites in the upstream promoter region. In eukaryotes, activation of expression is accompanied by the recruitment of activators to multiple enhancers, which may be distant from the core promoter, and the activators act through coactivators. The role of the general DNA architecture in transcription control increases in evolution. As a whole, it can be seen that enhancers of multicellular eukaryotes evolved from the corresponding prototypic enhancer-like regulatory elements with the gradually increasing genome size of organisms.
Citations by journals
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Citations by publishers
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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TY - JOUR
DO - 10.3390/cells9071675
UR - https://doi.org/10.3390%2Fcells9071675
TI - Evolution of Regulated Transcription
T2 - Cells
AU - Bylino, Oleg V
AU - Ibragimov, Airat N
AU - Shidlovskii, Y. V.
PY - 2020
DA - 2020/07/12 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1675
IS - 7
VL - 9
PMID - 32664620
SN - 2073-4409
ER -
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@article{2020_Bylino,
author = {Oleg V Bylino and Airat N Ibragimov and Y. V. Shidlovskii},
title = {Evolution of Regulated Transcription},
journal = {Cells},
year = {2020},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jul},
url = {https://doi.org/10.3390%2Fcells9071675},
number = {7},
pages = {1675},
doi = {10.3390/cells9071675}
}
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Bylino, Oleg V., et al. “Evolution of Regulated Transcription.” Cells, vol. 9, no. 7, Jul. 2020, p. 1675. https://doi.org/10.3390%2Fcells9071675.