Open Access
International Journal of Molecular Sciences, volume 22, issue 6, pages 2856
Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila
Shidlovskii Y. V.
1, 2, 3
,
Bylino Oleg V
3
,
Shaposhnikov Alexander V.
3
,
Kachaev Zaur M
2, 3
,
Lebedeva Lyubov A.
3
,
Kolesnik Valeria V
3
,
Amendola Diego
4
,
De Simone Giovanna
4, 5
,
Formicola Nadia
6, 7
,
Schedl Paul
3, 8
,
6
Institute of Research on Terrestrial Ecosystems (IRET) National Research Council (CNR), 05010 Porano, Italy
|
7
Institut de Biologie Valrose iBV UMR CNRS 7277, Université Côte d’Azur, 06108 Nice, France
|
8
Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA
|
Publication type: Journal Article
Publication date: 2021-03-11
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
33799739
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
The chromatin remodeler SWI/SNF is an important participant in gene activation, functioning predominantly by opening the chromatin structure on promoters and enhancers. Here, we describe its novel mode of action in which SWI/SNF factors mediate the targeted action of an enhancer. We studied the functions of two signature subunits of PBAP subfamily, BAP170 and SAYP, in Drosophila. These subunits were stably tethered to a transgene reporter carrying the hsp70 core promoter. The tethered subunits mediate transcription of the reporter in a pattern that is generated by enhancers close to the insertion site in multiple loci throughout the genome. Both tethered SAYP and BAP170 recruit the whole PBAP complex to the reporter promoter. However, we found that BAP170-dependent transcription is more resistant to the depletion of other PBAP subunits, suggesting that BAP170 may play a more critical role in establishing enhancer-dependent transcription.
Citations by journals
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1
2
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Frontiers in Genetics
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Frontiers in Genetics
2 publications, 33.33%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 16.67%
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Nature Communications
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Nature Communications
1 publication, 16.67%
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G3: Genes, Genomes, Genetics
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G3: Genes, Genomes, Genetics
1 publication, 16.67%
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Doklady Biochemistry and Biophysics
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Doklady Biochemistry and Biophysics
1 publication, 16.67%
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1
2
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Citations by publishers
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1
2
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 33.33%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 16.67%
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Springer Nature
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Springer Nature
1 publication, 16.67%
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Genetics Society of America
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Genetics Society of America
1 publication, 16.67%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 16.67%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Shidlovskii Y. V. et al. Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila // International Journal of Molecular Sciences. 2021. Vol. 22. No. 6. p. 2856.
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Shidlovskii Y. V., Bylino O. V., Shaposhnikov A. V., Kachaev Z. M., Lebedeva L. A., Kolesnik V. V., Amendola D., De Simone G., Formicola N., Schedl P., Digilio F. A., Giordano E. Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila // International Journal of Molecular Sciences. 2021. Vol. 22. No. 6. p. 2856.
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TY - JOUR
DO - 10.3390/ijms22062856
UR - https://doi.org/10.3390%2Fijms22062856
TI - Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila
T2 - International Journal of Molecular Sciences
AU - Shaposhnikov, Alexander V.
AU - Kolesnik, Valeria V
AU - Amendola, Diego
AU - De Simone, Giovanna
AU - Lebedeva, Lyubov A.
AU - Schedl, Paul
AU - Shidlovskii, Y. V.
AU - Bylino, Oleg V
AU - Kachaev, Zaur M
AU - Formicola, Nadia
AU - Digilio, Filomena Anna
AU - Giordano, Ennio
PY - 2021
DA - 2021/03/11 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 2856
IS - 6
VL - 22
PMID - 33799739
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2021_Shidlovskii,
author = {Alexander V. Shaposhnikov and Valeria V Kolesnik and Diego Amendola and Giovanna De Simone and Lyubov A. Lebedeva and Paul Schedl and Y. V. Shidlovskii and Oleg V Bylino and Zaur M Kachaev and Nadia Formicola and Filomena Anna Digilio and Ennio Giordano},
title = {Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {mar},
url = {https://doi.org/10.3390%2Fijms22062856},
number = {6},
pages = {2856},
doi = {10.3390/ijms22062856}
}
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MLA
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Shidlovskii, Y. V., et al. “Subunits of the PBAP Chromatin Remodeler Are Capable of Mediating Enhancer-Driven Transcription in Drosophila.” International Journal of Molecular Sciences, vol. 22, no. 6, Mar. 2021, p. 2856. https://doi.org/10.3390%2Fijms22062856.