Open Access
Pt(Iv) prodrugs with nsaids as axial ligands
Daniil Spector
1, 2
,
Olga O. Krasnovskaya
1, 2
,
Kirill G. Pavlov
2
,
Alexander Erofeev
1, 2
,
Peter Gorelkin
1, 2
,
Alexander Majouga
1, 2, 3
2
Тип публикации: Journal Article
Дата публикации: 2021-04-07
scimago Q1
wos Q1
БС1
SJR: 1.273
CiteScore: 9.0
Impact factor: 4.9
ISSN: 16616596, 14220067
PubMed ID:
33917027
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Краткое описание
A chemo-anti-inflammatory strategy is of interest for the treatment of aggressive cancers. The platinum (IV) prodrug with non-steroidal anti-inflammatory drugs (NSAIDs) as axial ligands is designed to efficiently enter tumor cells due to high lipophilicity and release the cytotoxic metabolite and NSAID intracellularly, thereby reducing side effects and increasing the therapeutic efficacy of platinum chemotherapy. Over the last 7 years, a number of publications have been devoted to the design of such Pt(IV) prodrugs in combination with anti-inflammatory chemotherapy, with high therapeutic efficacy in vitro and In vivo. In this review, we summarize the studies devoted to the development of Pt(IV) prodrugs with NSAIDs as axial ligands, the study of the mechanism of their cytotoxic action and anti-inflammatory activity, the structure–activity ratio, and therapeutic efficacy.
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ГОСТ |
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BibTex |
MLA
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ГОСТ
Скопировать
Spector D. et al. Pt(Iv) prodrugs with nsaids as axial ligands // International Journal of Molecular Sciences. 2021. Vol. 22. No. 8. p. 3817.
ГОСТ со всеми авторами (до 50)
Скопировать
Spector D., Krasnovskaya O. O., Pavlov K. G., Erofeev A., Gorelkin P., Beloglazkina E., Majouga A. Pt(Iv) prodrugs with nsaids as axial ligands // International Journal of Molecular Sciences. 2021. Vol. 22. No. 8. p. 3817.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.3390/ijms22083817
UR - https://www.mdpi.com/1422-0067/22/8/3817
TI - Pt(Iv) prodrugs with nsaids as axial ligands
T2 - International Journal of Molecular Sciences
AU - Spector, Daniil
AU - Krasnovskaya, Olga O.
AU - Pavlov, Kirill G.
AU - Erofeev, Alexander
AU - Gorelkin, Peter
AU - Beloglazkina, Elena
AU - Majouga, Alexander
PY - 2021
DA - 2021/04/07
PB - MDPI
SP - 3817
IS - 8
VL - 22
PMID - 33917027
SN - 1661-6596
SN - 1422-0067
ER -
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BibTex (до 50 авторов)
Скопировать
@article{2021_Spector,
author = {Daniil Spector and Olga O. Krasnovskaya and Kirill G. Pavlov and Alexander Erofeev and Peter Gorelkin and Elena Beloglazkina and Alexander Majouga},
title = {Pt(Iv) prodrugs with nsaids as axial ligands},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {MDPI},
month = {apr},
url = {https://www.mdpi.com/1422-0067/22/8/3817},
number = {8},
pages = {3817},
doi = {10.3390/ijms22083817}
}
Цитировать
MLA
Скопировать
Spector, Daniil, et al. “Pt(Iv) prodrugs with nsaids as axial ligands.” International Journal of Molecular Sciences, vol. 22, no. 8, Apr. 2021, p. 3817. https://www.mdpi.com/1422-0067/22/8/3817.