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Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

Mollaeva M.R., Yabbarov N., Sokol M., Chirkina M., Mollaev M.D., Zabolotskii A., Seregina I., Bolshov M., Kaplun A., Nikolskaya E.
Тип документаJournal Article
Дата публикации2021-11-12
Название журналаInternational Journal of Molecular Sciences
ИздательMultidisciplinary Digital Publishing Institute (MDPI)
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 20216.21
ISSN16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Краткое описание

The selection of technological parameters for nanoparticle formulation represents a complicated development phase. Therefore, the statistical analysis based on Box–Behnken methodology is widely used to optimize technological processes, including poly(lactic-co-glycolic acid) nanoparticle formulation. In this study, we applied a two-level three-factor design to optimize the preparation of nanoparticles loaded with cobalt (CoTPP), manganese (MnClTPP), and nickel (NiTPP) metalloporphyrins (MeP). The resulting nanoparticles were examined by dynamic light scattering, X-ray diffraction, Fourier transform infrared spectroscopy, MTT test, and hemolytic activity assay. The optimized model of nanoparticle formulation was validated, and the obtained nanoparticles possessed a spherical shape and physicochemical characteristics enabling them to deliver MeP in cancer cells. In vitro hemolysis assay revealed high safety of the formulated MeP-loaded nanoparticles. The MeP release demonstrated a biphasic profile and release mechanism via Fick diffusion, according to release exponent values. Formulated MeP-loaded nanoparticles revealed significant antitumor activity and ability to generate reactive oxygen species. MnClTPP- and CoTPP-nanoparticles specifically accumulated in tissues, preventing wide tissue distribution caused by long-term circulation of the hydrophobic drug. Our results suggest that MnClTPP- and CoTPP-nanoparticles represent the greatest potential for utilization in in anticancer therapy due to their effectiveness and safety.

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1. Mollaeva M.R. и др. Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles // International Journal of Molecular Sciences. 2021. Т. 22. № 22. С. 12261.
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TY - JOUR

DO - 10.3390/ijms222212261

UR - http://dx.doi.org/10.3390/ijms222212261

TI - Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles

T2 - International Journal of Molecular Sciences

AU - Mollaeva, Mariia R.

AU - Yabbarov, Nikita

AU - Sokol, Maria

AU - Chirkina, Margarita

AU - Mollaev, Murad D.

AU - Zabolotskii, Artur

AU - Seregina, Irina

AU - Bolshov, Mikhail

AU - Kaplun, Alexander

AU - Nikolskaya, Elena

PY - 2021

DA - 2021/11/12

PB - MDPI AG

SP - 12261

IS - 22

VL - 22

SN - 1422-0067

ER -

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@article{Mollaeva_2021,

doi = {10.3390/ijms222212261},

url = {https://doi.org/10.3390%2Fijms222212261},

year = 2021,

month = {nov},

publisher = {{MDPI} {AG}},

volume = {22},

number = {22},

pages = {12261},

author = {Mariia R. Mollaeva and Nikita Yabbarov and Maria Sokol and Margarita Chirkina and Murad D. Mollaev and Artur Zabolotskii and Irina Seregina and Mikhail Bolshov and Alexander Kaplun and Elena Nikolskaya},

title = {Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded {PLGA} Nanoparticles},

journal = {International Journal of Molecular Sciences}

}

MLA
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Mollaeva, Mariia R. et al. “Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles.” International Journal of Molecular Sciences 22.22 (2021): 12261. Crossref. Web.