Open Access
International Journal of Molecular Sciences, volume 22, issue 22, pages 12261
Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles
Mollaeva Mariia R
1, 2
,
Yabbarov Nikita G
1, 2
,
Sokol Maria
1, 2
,
Chirkina Margarita
1, 2
,
Mollaev Murad D
1, 3
,
Zabolotskii Artur
1, 4
,
Seregina Irina
4
,
Bol'shov M.A.
4
,
Kaplun Alexander
5
,
Nikolskaya Elena D
1, 2
1
JSC Russian Research Center for Molecular Diagnostics and Therapy, 117149 Moscow, Russia
|
2
Publication type: Journal Article
Publication date: 2021-11-12
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
34830136
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
The selection of technological parameters for nanoparticle formulation represents a complicated development phase. Therefore, the statistical analysis based on Box–Behnken methodology is widely used to optimize technological processes, including poly(lactic-co-glycolic acid) nanoparticle formulation. In this study, we applied a two-level three-factor design to optimize the preparation of nanoparticles loaded with cobalt (CoTPP), manganese (MnClTPP), and nickel (NiTPP) metalloporphyrins (MeP). The resulting nanoparticles were examined by dynamic light scattering, X-ray diffraction, Fourier transform infrared spectroscopy, MTT test, and hemolytic activity assay. The optimized model of nanoparticle formulation was validated, and the obtained nanoparticles possessed a spherical shape and physicochemical characteristics enabling them to deliver MeP in cancer cells. In vitro hemolysis assay revealed high safety of the formulated MeP-loaded nanoparticles. The MeP release demonstrated a biphasic profile and release mechanism via Fick diffusion, according to release exponent values. Formulated MeP-loaded nanoparticles revealed significant antitumor activity and ability to generate reactive oxygen species. MnClTPP- and CoTPP-nanoparticles specifically accumulated in tissues, preventing wide tissue distribution caused by long-term circulation of the hydrophobic drug. Our results suggest that MnClTPP- and CoTPP-nanoparticles represent the greatest potential for utilization in in anticancer therapy due to their effectiveness and safety.
Citations by journals
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International Journal of Molecular Sciences
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2 publications, 16.67%
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1 publication, 8.33%
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Journal of Personalized Medicine
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1 publication, 8.33%
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Photodiagnosis and Photodynamic Therapy
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European Polymer Journal
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1 publication, 8.33%
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Nanomaterials
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1 publication, 8.33%
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Antibiotiki i Khimioterapiya
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1 publication, 8.33%
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Physics of Atomic Nuclei
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1 publication, 8.33%
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1
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Citations by publishers
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1
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3
4
5
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7
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
7 publications, 58.33%
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Elsevier
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Elsevier
2 publications, 16.67%
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Wiley
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Wiley
1 publication, 8.33%
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Publishing House OKI
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Publishing House OKI
1 publication, 8.33%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 8.33%
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1
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3
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5
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7
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Mollaeva M. R. et al. Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles // International Journal of Molecular Sciences. 2021. Vol. 22. No. 22. p. 12261.
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Mollaeva M. R., Yabbarov N. G., Sokol M., Chirkina M., Mollaev M. D., Zabolotskii A., Seregina I., Bol'shov M., Kaplun A., Nikolskaya E. D. Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles // International Journal of Molecular Sciences. 2021. Vol. 22. No. 22. p. 12261.
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TY - JOUR
DO - 10.3390/ijms222212261
UR - https://doi.org/10.3390%2Fijms222212261
TI - Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles
T2 - International Journal of Molecular Sciences
AU - Mollaeva, Mariia R
AU - Sokol, Maria
AU - Chirkina, Margarita
AU - Mollaev, Murad D
AU - Zabolotskii, Artur
AU - Seregina, Irina
AU - Kaplun, Alexander
AU - Yabbarov, Nikita G
AU - Bol'shov, M.A.
AU - Nikolskaya, Elena D
PY - 2021
DA - 2021/11/12 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 12261
IS - 22
VL - 22
PMID - 34830136
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2021_Mollaeva,
author = {Mariia R Mollaeva and Maria Sokol and Margarita Chirkina and Murad D Mollaev and Artur Zabolotskii and Irina Seregina and Alexander Kaplun and Nikita G Yabbarov and M.A. Bol'shov and Elena D Nikolskaya},
title = {Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2Fijms222212261},
number = {22},
pages = {12261},
doi = {10.3390/ijms222212261}
}
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MLA
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Mollaeva, Mariia R., et al. “Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles.” International Journal of Molecular Sciences, vol. 22, no. 22, Nov. 2021, p. 12261. https://doi.org/10.3390%2Fijms222212261.