Open Access
International Journal of Molecular Sciences, volume 22, issue 24, pages 13405
Carbonic anhydrase IX inhibitors as candidates for combination therapy of solid tumors
Publication type: Journal Article
Publication date: 2021-12-14
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
PubMed ID:
34948200
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Combination therapy is becoming imperative for the treatment of many cancers, as it provides a higher chance of avoiding drug resistance and tumor recurrence. Among the resistance-conferring factors, the tumor microenvironment plays a major role, and therefore, represents a viable target for adjuvant therapeutic agents. Thus, hypoxia and extracellular acidosis are known to select for the most aggressive and resilient phenotypes and build poorly responsive regions of the tumor mass. Carbonic anhydrase (CA, EC 4.2.1.1) IX isoform is a surficial zinc metalloenzyme that is proven to play a central role in regulating intra and extracellular pH, as well as modulating invasion and metastasis processes. With its strong association and distribution in various tumor tissues and well-known druggability, this protein holds great promise as a target to pharmacologically interfere with the tumor microenvironment by using drug combination regimens. In the present review, we summarized recent publications revealing the potential of CA IX inhibitors to intensify cancer chemotherapy and overcome drug resistance in preclinical settings.
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Citations by publishers
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9
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Multidisciplinary Digital Publishing Institute (MDPI)
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9 publications, 42.86%
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3 publications, 14.29%
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1 publication, 4.76%
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1 publication, 4.76%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kalinin S. et al. Carbonic anhydrase IX inhibitors as candidates for combination therapy of solid tumors // International Journal of Molecular Sciences. 2021. Vol. 22. No. 24. p. 13405.
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Kalinin S., Malkova A., Sharonova T., Sharoyko V., Bunev A. S., T Supuran C., Krasavin M. Carbonic anhydrase IX inhibitors as candidates for combination therapy of solid tumors // International Journal of Molecular Sciences. 2021. Vol. 22. No. 24. p. 13405.
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TY - JOUR
DO - 10.3390/ijms222413405
UR - https://doi.org/10.3390%2Fijms222413405
TI - Carbonic anhydrase IX inhibitors as candidates for combination therapy of solid tumors
T2 - International Journal of Molecular Sciences
AU - Malkova, Anna
AU - Sharonova, Tatiana
AU - Kalinin, Stanislav
AU - Sharoyko, Vladimir
AU - Bunev, Alexander S.
AU - T Supuran, Claudiu
AU - Krasavin, Mikhail
PY - 2021
DA - 2021/12/14 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 13405
IS - 24
VL - 22
PMID - 34948200
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2021_Kalinin,
author = {Anna Malkova and Tatiana Sharonova and Stanislav Kalinin and Vladimir Sharoyko and Alexander S. Bunev and Claudiu T Supuran and Mikhail Krasavin},
title = {Carbonic anhydrase IX inhibitors as candidates for combination therapy of solid tumors},
journal = {International Journal of Molecular Sciences},
year = {2021},
volume = {22},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {dec},
url = {https://doi.org/10.3390%2Fijms222413405},
number = {24},
pages = {13405},
doi = {10.3390/ijms222413405}
}
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MLA
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Kalinin, Stanislav, et al. “Carbonic anhydrase IX inhibitors as candidates for combination therapy of solid tumors.” International Journal of Molecular Sciences, vol. 22, no. 24, Dec. 2021, p. 13405. https://doi.org/10.3390%2Fijms222413405.